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| 1 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 2 | 神经连接蛋白-3缺乏可阻止高分级神经胶质瘤生长显示文摘在一项新的研究中,来自美国国家卫生研究院、斯坦福大学、达纳法伯癌症研究所和哈佛医学院的研究人员发现某些侵袭性脑瘤的生长能够通过切断它们获取大脑中神经细胞产生的一种信号分子加以阻止.这些研究人员发现当这种被称作神经连接蛋白-3(neuroligin-3,NLGN3)的信号分子缺乏时,或者当利用药物干扰这种信号分子时,人高分级神经胶质瘤不能够在小鼠大脑中扩散. | Venkatesh H S Tam L T Woo P J | 2017 | 临床误诊误治2017，30，11： | 3 |
| 3 | Barefoot rnn- ning:An evaluation of current hypothesis future research and clinical applications显示文摘 | TAM N WILSON J L A NOAKES T D | 2014 | Br J Sports Med2014，48，： | 1 |
| 4 | Capsaicin-sensitive local sensory innervation is involved in pacing-induced preconditioning in rat hearts: role of nitric oxide and CGRP?显示文摘 | P. Ferdinandy Tamás Csont Csaba Csonka Marianna T?r?k Mária Dux József Németh László I. Horváth László Dux Zoltán Szilvássy Gábor Jancsó | 1997 | Naunyn - Schmiedeberg’s Archives of Pharmacology1997，，3： | 1 |
| 5 | Non-structural fuzzy decision support system for evaluation of construction safety management system 显示文摘 | TAM C M TONG T K L CHIU G C V | 2002 | International Journal of Project Manage- ment2002，20，4： | 1 |
| 6 | Comparing non-structural fuzzy decision support system and analytic hierarchy process in decision-making for construction problems显示文摘 | TAM C M TONG T K L CHIU G W C | 2006 | European Journal of Operational Research2006，，174： | 1 |
| 7 | Infiltration of bupivacaine local anesthetic to trocar insertion sites after laparoscopy: a randomized, double-blind, stratified, and controlled trial显示文摘 | Tam T Harkins G Wegrzyniak L | 2014 | J Minim Invasive Gynecol2014，21，6： | 1 |
| 8 | Diagnosis of prestressed concrete pile defects using probabilistic neural networks显示文摘 | TAM C M TONG T K L | 2004 | Eng Struct2004，26，8： | 1 |
| 9 | Production of bihon-type noodles from maize starch differing in amylose content显示文摘 | Tam L M Corke H Tan W T | 2004 | Cereal Chemistry2004，81，4： | 1 |
| 10 | Arterial territories of the human brain: cerebral hemispheres 显示文摘 | Tam L Moulin T Bogousslavsky J | 1998 | Neurology1998，50，： | 1 |
| 11 | Fiber bragg grating sensors for structural health monitoring of rising Ma Bridge : Background and experimental observation 显示文摘 | CHANT H T YU L TAM H Y | 2006 | Engineering Structures2006，28，5： | 1 |
| 12 | Venous thromboembolism in pregnant Chinese women 显示文摘 | Chan L Y Tam W H Lau T K | 2001 | Obstet Gynecol2001，98，3： | 1 |
| 13 | Association of complement factor H polymorphisms with exudative agerelated macular degeneration 显示文摘 | Chen L J Liu D T Tam P O | 2006 | Mol Vision2006，12，： | 1 |
| 14 | Compressed indexing and local alignment of DNA显示文摘 | LAM T W SUNG W K TAM S L | 2008 | Bioinformatics2008，24，6： | 1 |
| 15 | Non-structural fuzzy decision support system for evaluation of construction safety management system 显示文摘 | TAM C M THOMAS K L T | 2002 | International Journal of Project Management2002，20，： | 1 |
| 16 | Diagnosis of prestressed concrete pile defects using probabilistic neural networks 显示文摘 | Tam C M Tong T K L Lau T C T | 2004 | Engineering Structures2004，26，： | 1 |
| 17 | Fiber bragg grating sensors for structural health monitoring of Tsing Ma Bridge : background and experimental observation 显示文摘 | Chan T H T Yu L Tam H Y | 2006 | Engineering Structures2006，28，5： | 1 |
| 18 | Surveillance and correlation of antibiotic prescription and resistance of Gram-negative bacteria in Singaporean hospitals显示文摘 | Hsu L Y Tan T Y Tam V H | 2010 | Antimicrob Agents Che- mother2010，54，3： | 1 |
| 19 | A pilot study for wastewater reclamation and reuse with MBR/RO and MF/RO systems显示文摘 | TAM L S TANGA T W LAU G N | 2007 | Desalination2007，202，13： | 1 |
| 20 | Predictors of maternal and fetal outcomes in pregnancies of patients with systemic lupus erythematosus显示文摘 | Kwok L W Tam L S Zhu T etal | 2011 | Lupus2011，20，8： | 1 |
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