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| 1 | Visualizing the hepatic vascular architecture using superb microvascular imaging in patients with hepatitis C virus: A novel technique显示文摘AIM: To identify the hepatic vascular architecture of patients with hepatitis C virus(HCV) using superb microvascular imaging(SMI) and investigate the use of SMI in the evaluation of liver fibrosis.METHODS: SMI was performed in 100 HCV patients. SMI images were classified into five types according to the vascular pattern, and these patterns were compared with the fibrosis stage. Moreover, the images were analyzed to examine vascularity by integrating the number of SMI signals in the region of interest ROI [number of vascular trees(VT)]. The number of VT, fibrosis stage, serum parameters of liver function, and CD34 expression were investigated.RESULTS: There was a significant difference between SMI distribution pattern and fibrosis stage(P < 0.001). The mean VT values in each of the fibrosis stages were as follows: 26.69 ± 7.08 in F0, 27.72 ± 9.32 in F1, 36.74 ± 9.23 in F2, 37.36 ± 5.32 in F3, and 58.14 ± 14.08 in F4. The VT showed excellent diagnostic ability for F4 [area under the receiver operator characteristic(AUROC): 0.911]. The VT was significantly correlated with the CD34 labeling index(r = 0.617, P < 0.0001).CONCLUSION: SMI permitted the detailed delineation of the vascular architecture in chronic liver disease. SMI appears to be a reliable tool for noninvasively detecting significant fibrosis or cirrhosis in HCV patients. | Hidekatsu Kuroda Tamami Abe Keisuke Kakisaka Yudai Fujiwara Yuichi Yoshida Akio Miyasaka Kazuyuki Ishida Hideaki Ishida Tamotsu Sugai Yasuhiro Takikawa | 2016 | World Journal of Gastroenterology2016，22，26： | 12 |
| 2 | Change in arterial tumor perfusion is an early biomarker of lenvatinib efficacy in patients with unresectable hepatocellular carcinoma显示文摘BACKGROUND Lenvatinib is one of the first-line tyrosine kinase inhibitors used for unresectable hepatocellular carcinoma(HCC). In the present study, we evaluated the potential of early changes in the time-intensity curve(TIC) of arterial phase on contrastenhanced ultrasound(CEUS) as early imaging biomarkers of lenvatinib efficacy.AIM To evaluate the potential of the early changes in the TIC of CEUS as early imaging biomarkers of lenvatinib efficacy in patients with unresectable HCC.METHODS We analyzed 20 consecutive patients with unresectable HCC treated with lenvatinib from March to November 2018. Tumor response at 8 wk was assessed by computed tomography using the modified Response Evaluation Criteria in Solid Tumors(m RECIST). CEUS was performed at baseline before treatment(Day 0) and on day 7(Day 7), and the images were analyzed in the arterial phase for 20 seconds after the contrast agent arrived at the target tumor. Three perfusion parameters were extracted from the TICs: the slope of wash-in(Slope),time to peak(TTP) intensity, and the total area under the curve(AUC) during wash-in. The rate of change in the TIC parameters between Day 0 and Day 7 was compared between treatment responders and non-responders based on m RECIST.RESULTS The rate of change for all TIC parameters showed significant differences between the responders(n = 9) and non-responders(n = 11)(Slope, P = 0.025; TTP, P =0.004; and AUC, P = 0.0003). The area under the receiver operating curve values for slope, TTP, and AUC for the prediction of responders were 0.805, 0.869, and0.939, respectively.CONCLUSION CEUS may be useful for the early prediction of tumor response to lenvatinib therapy in patients with unresectable HCC. | Hidekatsu Kuorda Tamami Abe Yudai Fujiwara Takuya Okamoto Miki Yonezawa Hiroki Sato Kei Endo Takayoshi Oikawa Kei Sawara Yasuhiro Takikawa | 2019 | World Journal of Gastroenterology2019，25，19： | 8 |
| 3 | Long-lasting responses after discontinuation of nivolumab treatment for reasons other than tumor progression in patients with previously treated,advanced non-small cell lung cancer显示文摘Dear Editor,Nivolumab,an inhibitor of programmed cell death 1(PD-1),is an immune checkpoint inhibitor(ICI)that enhances T cell functions by preventing negative regulation of cancer immunity,and it has shown clinically significant efficacy and tolerability in various types of cancer.Based on the results of randomized phase III trials comparing nivolumab with docetaxel[1,2],nivolumab is now used in clinical practice for patients with previously treated advanced non-small cell lung cancer(NSCLC).Fur-thermore,the most recent Japan Lung Cancer Society guidelines include nivolumab monotherapy in the sys-temic treatment strategy for previously treated,locally advanced or metastatic NSCLC[3].However,ICIs induce characteristic immune-related adverse events(irAEs),which are not seen with conventional cytotoxic agents or molecular targeted agents.IrAEs can occur in any organ system,most typically the skin,lung,and gastrointesti-nal,hepatic,and endocrine systems. | Hideharu Kimura Tomoyuki Araya Taro Yoneda Hiroki Shirasaki Koji Kurokawa Tamami Sakai Hayato Koba Yuichi Tambo Shingo Nishikawa Takashi Sone Kazuo Kasahara | 2019 | Cancer Communications2019，39，1： | 3 |
| 4 | Usefulness and limitations of taste sensors in the evaluation of palatability and taste-masking in oral dosage forms显示文摘The purpose of this review is to discuss the advantages and limitations of taste sensors in the evaluation of the taste of palatability of different oral dosage forms. First, we consider some ways in which the palatability of various pharmaceutical formulations including orally disintegrating tablets(ODTs) are tested using two different taste sensors. Second, we focus on the evaluation of palatability of ODTs. We compare the usefulness of three pieces of apparatus for estimating the disintegration time of ODTs. Finally, we compare the characteristics of the two taste sensors in the evaluation of palatability of various kinds of drug formulations. | Tamami Haraguchi Miyako Yoshida Honami Kojima Takahiro Uchida | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，4： | 2 |
| 5 | Comparison of the polypeptide com ponents and amino acid composition between buckwheat protein fraction显示文摘 | Nishida Tamami | 1995 | Nippon Kasei Gakkaishi1995，46，8： | 1 |
| 6 | Chemoselective tetrahydropyranylation of alcohols and phenols using polystyrene supported aluminium chloride as a catalyst 显示文摘 | Tamami B Borujeny K P | 2004 | Tetrahedron Lett2004，45，： | 1 |
| 7 | Polymer supported bromates as new,versatile and efficient oxidizing reagents for various organic compounds显示文摘 | Tamami B Zarchi M A K | 1995 | Eur Polym1995，3，8： | 1 |
| 8 | 显示文摘 | Yeganeh H | 1999 | Eur Polym J1999，35，： | 1 |
| 9 | Preparation and properties of novel polyimides derived from 4-aryl-2,6 bis(4-amino phenyl) pyridine显示文摘 | Tamami B Yeganeh H | 2001 | J Polym Sci: Part A2001，39，： | 1 |
| 10 | Advanced glycation end product induced apoptosis and overexpression of vascular endothelial growth factor and monocyte chemoattractant protein-1 in human-cultured mesangial cells显示文摘 | Shoichi Y Yosuke I Tamami O | 2002 | J Biol Chem2002，277，20： | 1 |
| 11 | Bare metal stent implantation for in-stent restenosis with a drug-eluting stent显示文摘 | Hiroshi Matsuoka Hideo Kawakami Akira Ohshita Tamami Kohno Susumu Shigemi Hideki Okayama Jitsuo Higaki | 2009 | Journal of Cardiology2009，，1： | 1 |
| 12 | Idoine andiodine supported on polgvinyl pyrrolidone as catalysts and reagents foralcoholysis,hydrolysis, and acetollysis of epoxides and thiiranes显示文摘 | NasserIranpoor Bahman Tamami Khodabakhsh Niknam | 1997 | Can JChem1997，75，： | 1 |
| 13 | Incorporation of carbon dioxide into soybean oil and subsequent preparation and studies of nonisocyanate polyurethane networks 显示文摘 | Tamami B Sohn S Wilkes G L | 2004 | Appl Polym Sci2004，92，： | 1 |
| 14 | Preparation and Properties of Novel Polyimides Derived from 4-aryl-2, 6 Bis(4-Amino Phenyl) Pyridine 显示文摘 | Tamami B Yeganeh H | 2001 | J Polym Sci Part A : Polym Chem2001，39，21： | 1 |
| 15 | Studies on antihypertensive effect of luobuma (Apocynum venetum I~ ) leaf extract 显示文摘 | Tamami K Yoshihisa N Eijiro T | 2004 | Natural Medicines2004，58，3： | 1 |
| 16 | Synthesis and characterization of novel aromatic polyamides derived from 4-aryl-2,6-bis (4- aminophenyl) pyridines显示文摘 | Tamami B Yeganeh H | 2001 | Polymer2001，42，： | 1 |
| 17 | Advanced glycation end product induced apoptosis and overexpression ofvascular endothelial growth factor and monocyte chemoattractant protein-1 in human-cultured mesangial cells 显示文摘 | Sho-ichi Y Yosuke I Tamami O et a1 | 2002 | Biol Chem2002，277，20： | 1 |
| 18 | Incorporation of carbon dioxide into soybean oil and subsequent preparation and studies of nonisocyanate polyurethane networks显示文摘 | Tamami B Sohn S Wilkes G L | 2004 | Journal of Applied Polymer Science2004，92，2： | 1 |
| 19 | Incorporation of carbon dioxide into soybean oil and subsequent preparation and studies of nonisocyanate polyurethane networks 显示文摘 | TAMAMI B SOHN S WILKES G L | 2004 | Journal of Applied Polymer Science2004，92，： | 1 |
| 20 | Manufacture and Properties of Ultra-low-density Fiberboard显示文摘 | KAWASAKI Tamami ZHANG Min KAWAI Shuichi | 1998 | Jourmal of Wood Fiber Sci1998，44，5： | 1 |
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