|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 2 | Decomposition and Reformulation of Banxia Baizhu Tianma Decoction:A Vasodilatory Approach显示文摘Objective To decompose and reformulate Banxia Baizhu Tianma Decoction(BBT) in order to optimize its ratio for vasodilatory effect.The fingerprints of these six component herbs were also studied via Tri-step FTIR analysis.Methods The herbal components of BBT were extracted separately with different solvents,such as 95%ethanol,50%ethanol,and distilled water.The vasodilatory effect of the extracts was studied using the in vitro pre-contracted aortic ring model.Among these extracts,the water extracts of Pinellia ternata[PT(W)]and Citri reticulatae[CR(W)],50%ethanol extracts of Castrodia elata[GE(50)]and Clycyrrhiza uralensis[GU(50)],and 95%ethanol extracts of Atractylodes macrocephala[AM(E)],and Poria cocos[PC(E)]were selected for the orthogonal stimulus-response compatibility group study due to their high effectiveness in vasodilation.Results The best combination ratio(G2) was GE(50),GU(50),AM(E),PC(E),CR(W),and PT(W) at EC_0,EC_5,EC_5,EC_5,EC_5,and EC_5,with EC_(50) of(0.06 ± 0.01) mg/mL.Comparison between the vasodilatory effects of extracts derived from G2 and BBT were also studied.From the results,the 50%ethanol extract following G2 ratio was found to be most potent extract with the highest vasodilatory effect compared with other extracts derived from G2 or BBT,with EC_(50) of(0.05 ±0.005) mg/mL.Conclusion The optimum ratio and appropriate extraction method for the new BBT formulae are obtained.G2 is determined as the best formulae with the highest potency in producing the vasodilatory effect on isolated rat aortic rings.The results obtained suggest that 50%ethanol is found to be the best solvent to extract the vasoactive compounds of G2 in order to exhibit the highest efficacy of vasodilatory effect. | Chu Shan Tan Yean Chun Loh Yung Sing Ch'ng Mariam Ahmad Mohd.Zaini Asmawi Mun Fei Yam | 2017 | Chinese Herbal Medicines2017，9，2： | 3 |
| 3 | Functional polymorphisms of the cytochrome P450 1A2(CYP1A2) gene and prolonged QTc in- terval in schizophrenia显示文摘 | Tay JKX Tan CH Chong SA | 2007 | Prog Neuropsychopharmacol Biol Psy- chiatry2007，31，6： | 1 |
| 4 | The anterolateral thigh perforator flap for reconstruction of knee defects 显示文摘 | Wong CH Gob T Tan BK | 2013 | Ann Plast Surg2013，70，： | 1 |
| 5 | Specialized moisture retenfioneyewear for evaporative dry eye显示文摘 | Waduthantri S Tan CH Tong L | 2015 | Curt Eye Res2015，0，5： | 1 |
| 6 | Polymorphisms of dopamine receptors and tardive dyskinesia among Chinese patients with schizophrenia显示文摘 | Chong SA Tan EC Tan CH | 2003 | Am J Med Genet2003，116，1： | 1 |
| 7 | A molecular signature of the Nottingham prognostic index in breast cancer显示文摘 | Yu K Lee CH Tan PH | 2004 | Cancer Res2004，64，9： | 1 |
| 8 | GYY4137,a novel hydrogen sulfide-re- leasing molecule,protects against endotoxie shock in the rat显示文摘 | Li LSalto Tellez M Tan CH | 2009 | Free Radie Biol Med2009，47，1： | 1 |
| 9 | Correction of nipple inversion u- sing a micro-knife and transverse to longitudinal skin closure 显示文摘 | Cabalag MS Chui CH Tan BK | 2010 | Plast Reconstr Aesthet Surg2010，63，8： | 1 |
| 10 | Diffusion-weighted MRI in the de- tectlon of prostate cancer : meta-analysis 显示文摘 | Tan CH Wei W Johnson V | 2012 | AJR Am J Roentgenol2012，199，4： | 1 |
| 11 | Use of the soleus musculocutaneous perforator for skin paddle salvage of the fibula osteoseptocutaneous flap: anatomical study and clinical confirmation显示文摘 | Wong CH Tan BK Wei FC | 2007 | Plast Reconstr Surg2007，120，6： | 1 |
| 12 | Chest pain in the early postoperative period after laparoscopic adjustable gastric banding:four case reports显示文摘 | Tan CP Chia CH Leese T | | 0，，： | 1 |
| 13 | Nonlinear finite element simulations to elucidate the determinants of perforator patency in propeller flaps显示文摘 | Wong CH Cui F Tan BK | 2007 | Ann Plast Surg2007，59，6： | 1 |
| 14 | Antipsychotic drug prescription for schizophrenia in East Asia:rationale for change显示文摘 | Chong MY Tan CH Fujii S | 2004 | Psychiatry Clin Neurosciences2004，58，： | 1 |
| 15 | Involvement of matrix metalloproteinase-9 in stromal cell-derived factor-1/CXCR4 pathway of lung cancer metastasis显示文摘 | Tang CH Tan TW Fu WM | | 0，，： | 1 |
| 16 | Severe acute graft-versus-host disease occurring after syngeneic BMT for AML in a patient not given prior cyclosporin A therapy 显示文摘 | Hwang WY Goh YT Tan CH | 2000 | Bone Marrow Transplant2000，25，2： | 1 |
| 17 | Late thrombotic occlusion of paclitaxel eluting stent than one year after stent implantation 显示文摘 | Lee CH Tan HC Ong HY | 2004 | Heart2004，90，： | 1 |
| 18 | Preincisional subcutaneous infiltration of ketamine suppresses postoperative pain after circumcision surgery显示文摘 | Tan PH Cheng JT Kuo CH | 2007 | Clin J Pain2007，23，3： | 1 |
| 19 | Adaptive output feedback control of systems preceded by the preisach-type hysteresis显示文摘 | LI CH T TAN Y H | 2005 | IEEE Transactions on Systems Man and Cybernetics Part B : Cybernetics2005，35，1： | 1 |
| 20 | Long-term psychological outcome of 1999 Taiwan earthquake survivors: a survey of a high-risk sample with property damage 显示文摘 | Chen CH Tan HK Liao LR | 2007 | Compr Psychiatry2007，48，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员