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| 1 | Mechanisms of hepatocellular carcinoma progression显示文摘Hepatocellular carcinoma(HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib therapy only minimally enhances patient survival. This review provides a summary of some of the known mechanisms that either cause HCC or contribute to its progression. Included in this review are the roles of viral hepatitis, non-viral hepatitis, chronic alcohol intake, genetic predisposition and congenital abnormalities, toxic exposures, and autoimmune diseases of the liver. Well-established molecular mechanisms of HCC progression such as epithelial-mesenchymal transition, tumor-stromal interactions and the tumor microenvironment, cancer stem cells, and senescence bypass are also discussed. Additionally, we discuss the roles of circulating tumor cells,immunomodulation, and neural regulation as potential new mechanisms of HCC progression. A better understanding of these mechanisms could have implications for the development of novel and more effective therapeutic and prognostic strategies, which are critically needed. | Olorunseun O Ogunwobi Trisheena Harricharran Jeannette Huaman Anna Galuza Oluwatoyin Odumuwagun Yin Tan Grace X Ma Minhhuyen T Nguyen | 2019 | World Journal of Gastroenterology2019，25，19： | 21 |
| 2 | Two whitebacked planthopper resistance genes in rice share the same loci with those for brown planthopper resistance 显示文摘 | Tan O X Weng Q M Ren X | 2004 | Heredity2004，92，： | 1 |
| 3 | Firstprinciple electronic properties of dilute-As GaNAs alloy for visible light emitters显示文摘 | Tan C K Zhang J Li X H Liu G Y Tayo B O Tansu N | | 0，，04： | 1 |
| 4 | Effects of vitamin E on growth perfor- mance and antioxidant status in juvenile grass carp Ctenopharyngodon idellus 显示文摘 | Li J Liang X F Tan Q S et o/ | 2014 | Aquaculture2014，430，： | 1 |
| 5 | 显示文摘 | Chen X F Zhu W G Tan O K | 2000 | Mater Sci Eng B2000，77，： | 1 |
| 6 | Genetic polymor- phisms in the DNA double - strand break repair genes XRCC3, XRCC2 ,and NBS1 are not associated with acute side effects of ra- diotherapy in breast cancer patients显示文摘 | POPANDA O TAN X L CHRISTINE B | 2006 | Cancer Epidemiol Biomar- kers Prev2006，15，： | 1 |
| 7 | A simple miniaturization protocol to produce multi-component micro- and nanostructures显示文摘 | Ouyang Z Q Tan L Liu M Z Judge O S Zhang X D Li H Hu J Patten T E Liu G Y | 2006 | Small2006，2，7： | 1 |
| 8 | Development of DNA aptamers using Cell-SELEX显示文摘 | Sefah K Shangguan D Xiong X O'Donoghue M B Tan W | | 0，，： | 1 |
| 9 | Improvement in holographic storage capacity by use of double-random phase encryption 显示文摘 | TAN X MATOBA O SHIMURA T | 2001 | Appl Opt2001，40，26： | 1 |
| 10 | Ferroelectric (Ba, Sr) TiO3 thin films for H2 gas detection by sol - gel and R F sputtering 显示文摘 | Tan O K Chen X F Zhu W G | 1999 | Ferroelectrics1999，225，： | 1 |
| 11 | Weld residual stress effects on fatigue crack growth behaviour of aluminium alloy 2024-T351显示文摘 | LILJEDAHL C D M BROUARD J ZANELLATO O L1N J TAN M L GANGULY S IRVING P E FITZPATRICK M E ZHANG X EDWARDS L | 2009 | International Journal of Fatigue2009，31，： | 1 |
| 12 | 显示文摘 | Tan O K Chen X F Zhu W G | 1999 | Ferroelectrics1999，225，： | 1 |
| 13 | Ferroelectric (Ba,Sr)TiO3 thin films for H2 gas detection by SolGel and RF sputtering 显示文摘 | TAN O K CHEN X F ZHU W G | 1999 | Ferroelectrics1999，225，14： | 1 |
| 14 | 显示文摘 | Chert X F Zhu W G Tan O K | 2000 | Materinals Science and En- gineering B2000，77，2： | 1 |
| 15 | Social capital and social quilts:Network patterns of favor exchange显示文摘 | JACKSON M O RODRIGUEZ-BARRAQUER T TAN X | 2012 | The American Economic Review2012，102，5： | 1 |
| 16 | Limiting amino acids for growing goats fed a corn grain, soybean meal and maize stover based diet 显示文摘 | Shan J G Tan Z L Sun Z H Hu J P Tang S X Jiang H L Zhou C S Wang M Tayo G O | 2007 | Anim Feed Sci Tech2007，139，： | 1 |
| 17 | Secure optical storage that uses fully phase encryption显示文摘 | TAN X MATOBA O SHIMURA T | 2000 | Appl Opt2000，39，27： | 1 |
| 18 | Effects of yeast culture and fibrolytic enzyme supplementation on in vitro fermentation characteristics of low-quality cereal straws显示文摘 | Tang S X Tayo G O Tan Z L | 2008 | Journal of Animal Science2008，86，5： | 1 |
| 19 | Ferroelectric (Ba, Sr)TiO3 thin films for H2 gas detection by SolGel and RF sputtering 显示文摘 | TAN O K CHEN X F ZHU W G | 1999 | Ferroelectrics1999，225，14： | 1 |
| 20 | (Ba, Sr)TiO3 thin films by RF multitarget co-sputtering and hydrogen gas sensing显示文摘 | Chert X F Zhu W G Tan O K | 1999 | Ferroelectrics1999，232，： | 1 |
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