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| 1 | 解析胃癌前病变及早期胃癌的单细胞转录组网络显示文摘文章简介本研究采集了一组处于胃癌前病变不同阶段及早期胃癌患者,这些患者还具有胃灼痛、大便干燥、舌苔黄或厚等若干中医'胃火'相关临床表现。通过解析单细胞网络,研究发现高表达MUC6的腺粘膜细胞随着疾病的进展出现了肠样干细胞表型,提示其可能是介导肿瘤发生的关键步骤。 | 张鹏 Mingran Yang Yiding Zhang Shuai Xiao Xinxing Lai Aidi Tan Shiyu Du 李梢 | 2020 | 科学新闻2020，，2： | 7 |
| 2 | The effect of carbon nanotubes on osteogenic functions of adipose-derived mesenchymal stem cells in vitro and bone formation in vivo compared with that of nano-hydroxyapatite and the possible mechanism显示文摘It has been well recognized that the development and use of artificial materials with high osteogenic ability is one of the most promising means to replace bone grafting that has exhibited various negative effects.The biomimetic features and unique physiochemical properties of nanomaterials play important roles in stimulating cellular functions and guiding tissue regeneration.But efficacy degree of some nanomaterials to promote specific tissue formation is still not clear.We hereby comparatively studied the osteogenic ability of our treated multiwalled carbon nanotubes(MCNTs)and the main inorganic mineral component of natural bone,nano-hydroxyapatite(nHA)in the same system,and tried to tell the related mechanism.In vitro culture of human adiposederived mesenchymal stem cells(HASCs)on the MCNTs and nHA demonstrated that although there was no significant difference in the cell adhesion amount between on the MCNTs and nHA,the cell attachment strength and proliferation on the MCNTs were better.Most importantly,the MCNTs could induce osteogenic differentiation of the HASCs better than the nHA,the possible mechanism of which was found to be that the MCNTs could activate Notch involved signaling pathways by concentrating more proteins,including specific bone-inducing ones.Moreover,the MCNTs could induce ectopic bone formation in vivo while the nHA could not,which might be because MCNTs could stimulate inducible cells in tissues to form inductive bone better than nHA by concentrating more proteins including specific bone-inducing ones secreted from M2 macrophages.Therefore,MCNTs might be more effective materials for accelerating bone formation even than nHA. | Zhipo Du Xinxing Feng Guangxiu Cao Zhending She Rongwei Tan Katerina E.Aifantis Ruihong Zhang Xiaoming Li | 2021 | Bioactive Materials2021，6，2： | 3 |
| 3 | MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis显示文摘T cell-mediated immunity in the intestine is stringently controlled to ensure proper immunity against pathogenic microbes and to prevent autoimmunity,a known cause of inflammatory bowel disease.However,precisely how T cells regulate intestine immunity remains to be fully understood.In this study,we found that mitogen-activated protein kinase kinase kinase 2(MAP3K2)is required for the CD4^(+)T cell-mediated inflammation in the intestine.Using a T cell transfer colitis model,we found that MAP3K2-deficient naïve CD4^(+)T cells had a dramatically reduced ability to induce colitis compared to wild type T cells.In addition,significantly fewer IFN-γ-but more IL-17A-producing CD4^(+)T cells in the intestines of mice receiving MAP3K2-deficient T cells than in those from mice receiving wild type T cells was observed.Interestingly,under well-defined in vitro differentiation conditions,MAP3K2-deficient naïve T cells were not impaired in their ability to differentiate into Th1,Th17 and Treg.Furthermore,the MAP3K2-regulated colitis severity was mediated by Th1 but not Th17 cells in the intestine.At the molecular level,we showed that MAP3K2-mediated Th1 cell differentiation in the intestine was regulated by IL-18 and required specific JNK activation.Together,our study reveals a novel regulatory role of MAP3K2 in intestinal T cell immunity via the IL-18-MAP3K2-JNK axis and may provide a novel target for intervention in T cell-mediated colitis. | Ningbo Wu Dongping Chen Hongxiang Sun Jianmei Tan Yao Zhang Tianyu Zhang Yuheng Han Hongzhi Liu Xinxing Ouyang Xiao-Dong Yang Xiaoyin Niu Jie Zhong Zhengting Wang Bing Su | 2021 | Science China(Life Sciences)2021，64，3： | 3 |
| 4 | Constructing of the risk classification model of cervical cancer by artificial neural network 显示文摘 | Xiaoping Qiu Ning Tao Yun Tan Xinxing Wu | 2007 | Expert Systems with Applications2007，32，4： | 1 |
| 5 | Rheology Characterization of Sol-Gel Transition in Aqueous Alginate Solutions Induced by Calcium Cations Through in Situ Release显示文摘 | Liu Xinxing Qian Liying Shu Tan | 2003 | Polymer2003，44，2： | 1 |
| 6 | Constructing of the risk classification model of cervical cancer by artificial neural network显示文摘 | Xiaoping Qiu Ning Tao Yun Tan Xinxing Wu | 2007 | Expert Systems with Applications Volume 32 Issue 4 May 20072007，，： | 1 |
| 7 | Funetionalized graphene oxide-iron oxide nanocomposite for magnetically targeted drug deliver- y, photothermal therapy, and magnetic resonance imaging 显示文摘 | Xinxing Ma Huiquan Tan Kai Yang | 2012 | NanoReseareh2012，5，3： | 1 |
| 8 | The Main Diseases and Control Measures of Panax notoginseng(Burk) F. H. Chen in Wuzhou City显示文摘The main symptoms of root rot,anthracnose,blight and damping-off of Panax notoginseng( Burk) F. H. Chen are introduced in the paper,and the corresponding control measures are elaborated from the aspects of agricultural management measures,seed disinfection,seedbed treatment and chemical control. | Chen Yinghui Liu Zhuowu Qiu Weihua Tan Xinxing Li Jinfeng | 2014 | Plant Diseases and Pests2014，5，2： | 1 |
| 9 | Drought Tolerance Identification and Eevluation of Maize during Flowering Stage in Guangxi显示文摘Total 20 maize varieties were subjected to drought stress at flowering stage,and then the relative water content,soluble sugar content,chlorophyll content,malondialdehyde( MDA) content and superoxide dismutase( SOD) activity in their leaves,as well as their yields were determined. The drought tolerance of the physiological and biochemical indexes was scored by five-level scoring method,and the drought tolerance index was calculated by the yield index to comprehensively evaluate the drought tolerance of maize during flowering stage. The results showed that the scores of drought tolerance of the maize varieties ranged from 1. 929 3 to 5. 659 5. Among them,the scores of Zhengda 619,Guidan 162 and Guidan 0810 were greater than 5. 0,followed by Dika 008,Xianyu 30 T60,Xianzhengda 901,Qingnong 68,South America No. 1 and Wanchuan 1306 of which the scores were in the range of 4. 0-5. 0. The drought tolerance indexes were in the range of 0. 410 4-1. 096 3. Among the test maize varieties,the drought tolerance indexes of Guidan 0810,Pacific 99 and Zhengda 619 were greater than 1. 0,and those of Xianyu 30 T60,Dika 008 and South America No. 1 were in the range of 0. 9-1. 0. The correlation between the two kinds of evaluation results was 0. 588 7 and was extremely significant. The five-level scoring method and the drought tolerance index can be used simultaneously for the evaluation of drought tolerance of maize during flowering stage. The two aspects of evaluation results showed that Guidan 0810,Zhengda 619,Xianyu 30 T60,Dika 008 and South America No. 1 were drought-tolerant varieties,among which Guidan 0810 and Zhengda 619 were extremely highly drought-tolerant varieties. | Chenglin ZOU Hua TAN Debo ZHENG Ruining ZHAI Aihua HUANG Runxiu MO Xinxing WEI Kaijian HUANG | 2019 | Asian Agricultural Research2019，11，6： | 0 |
| 10 | HLA-B*6701 as a Subtype Performing Post-Selected Marking Gene for Cervical Cancer显示文摘A method of sequence-based typing(SBT) has been adopted to assort types of exons 2 and 3,which have the most polymorphism,of HLA-B locus of the Tujia nation group in Hubei province.The correlation among the HLA-B alleles,human papillomavirus(HPV) infection and cervical cancer risk has also been investigated.Under the condition of resident location and age,race unified,100 specimens of cancer patients were sampled as a case group,of which 86 were HPV positive and were screened for HLA-B alleles;while 187 specimens were taken from healthy people,of which 92 were HPV negative as a control group.The result shows that by comparing the above mentioned 86 HPV positive cervical cancer group and 92 HPV negative normal group,it was concluded that HLA-B*6701 was only found in the cervical cancer group(p<0.034),which shows that HLA-B*6701 can be used as an important candidate biological marking gene for generation of cervical cancer in Wufeng county of Hubei province. | QIU Xiaoping TAO Ning TAN Yun WU Xinxing | 2010 | Wuhan University Journal of Natural Sciences2010，15，6： | 0 |
| 11 | Effect of Foliar Application of Selenium Fertilizer on Yield,Selenium Content and Heavy Metal Contents of Waxy Maize显示文摘[Objectives]This study aimed to explore the effect of different concentrations of selenium fertilizer on the yield,selenium content and heavy metal contents of waxy maize,thereby providing reference for the scientific application of selenium fertilizer on waxy maize.[Methods]Different varieties of waxy maize(Guitiannuo 611,Guinuo 615 and Guiheinuo 609)were used as test materials.They were sprayed with different concentrations(0,0.5,1.0,1.5 and 2.0 g/L)of water-soluble selenium fertilizer(Xinxibao)at the big flare stage,and the effect on the yield,selenium content and heavy metal contents of the waxy maize was analyzed.[Results]Foliar application of different concentrations of selenium fertilizer showed no significant effect on the yield and yield components of waxy maize.As the concentration of selenium fertilizer increased,the grain selenium content of different varieties of waxy maize increased.Among them,the increase of Guinuo 615 was the largest,of which the selenium content reached 0.265 mg/kg,2.82 times that of the control(water).The cadmium and arsenic contents of different varieties of waxy maize decreased with the increase of the concentration of selenium fertilizer sprayed.Among the waxy maize varieties,the cadmium and arsenic contents of Guitiannuo 611 dropped the most significantly,up to 52.94%and 77.78%.In waxy maize,the correlation coefficients between selenium content and cadmium,arsenic contents were-0.5509(P<0.05)and-0.8530(P<0.01),respectively.[Conclusions]Spraying exogenous selenium fertilizer had no obvious effect on the yield of waxy maize.However,the increase of the concentration of exogenous selenium fertilizer could significantly increase the selenium content and reduce the cadmium and arsenic contents in grains of different varieties of waxy maize. | Chenglin ZOU Ruining ZHAI Kaijian HUANG Hua TAN Debo ZHENG Aihua HUANG Xinxing WEI Runxiu MO Faqian XIONG Hui WEI Shanzhu WEI | 2020 | Asian Agricultural Research2020，12，8： | 0 |
| 12 | Effect of Drought Stress on Proteome of Maize Grain during Grain Filling显示文摘Based on isobaric tags for relative and absolute quantification(iTRAQ)technology,the proteome of grains of a maize cultivar Huangzao 4 under drought stress at grain filling stage was analyzed.The results show that under drought stress,438 proteins were differentially expressed in the maize grains during grain filling.Among them,200 were up-regulated and 238 were down-regulated.The gene ontology(GO)analysis shows that the biological processes in which differential proteins are more involved are cellular processes,metabolic processes and single biological processes;proteins in the cell component category are mainly distributed in cells,cell parts and organelles;and the proteins the molecular function category mainly possess catalytic activity and binding function.Differentially expressed proteins classified by COG are mainly involved in protein post-translational modification and transport,molecular chaperones,general functional genes,translation,ribosomal structure,biosynthesis,energy production and transformation,carbohydrate transport and metabolism,amino acid transport and metabolism,etc.The subcellular structure of the differentially expressed proteins is mainly located in the cell chloroplast and cytosol.The proportions are 35.01%and 30.21%respectively.KEGG metabolic pathway enrichment analysis shows that the differentially expressed proteins are mostly involved in antibiotic biosynthesis,microbial metabolism in different environments,and endoplasmic reticulum protein processing;the metabolic pathways with higher enrichment are the carbon fixation pathway and estrogen signaling pathway of prokaryotes;and the higher enrichment and greater significance are in the tricarboxylic acid cycle,carbon fixation of photosynthetic organisms and proteasome.The results of this study preliminarily reveal the adaptive mechanism of maize grains in response to drought stress during grain filling,providing a theoretical reference for maize drought-resistant molecular breeding. | Chenglin ZOU Debo ZHENG Hua TAN Kaijian HUANG Aihua HUANG Xinxing WEI Runxiu MO Ruining ZHAI | 2021 | Asian Agricultural Research2021，13，1： | 0 |
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