|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Retardant effect of dihydroartemisinin on ulcerative colitis in a JAK2/STAT3-dependent manner显示文摘Dihydroartemisinin(DHA)is a semi-synthetic derivative and the main active metabolite of artemisinin.The purpose of this study was to investigate the effect of DHA on the ulcerative colitis(UC)in both in vivo and in vitro models.Weight,survival rate,colon length,and Disease Activity Index score were used to evaluate the severity of colitis.Reverse transcription quantitative polymerase chain reaction and enzyme-linked immunosorbent assay were used to detect the expressions of cytokines interleukin(IL)-1,IL-1β,IL-4,IL-6,IL-10,IL-12,and tumor necrosis factor-α(TNF-α).The expressions of Janus kinase 2(JAK2)and signal transducer and activator of transcription 3(STAT3),and the phosphorylation of JAK2(p-JAK2)and STAT3(p-STAT3),were measured by western blot analysis.Western blot analysis and immunohistochemistry were used to detect the expressions of tight junction proteins.We found that the weights and colon lengths of mice in dextran sodium sulfate(DSS)+DHA group were significantly lower and longer than those in the DSS group,respectively.Compared with those in the DSS group,the expressions of IL-1β,IL-6,IL-17,and TNF-αin the DSS+DHA and DSS+5-aminosalicylic acid(5-ASA)groups were decreased,while the expressions of IL-4 and IL-10 were significantly upregulated.DHA largely increased the expressions of zonula occludens-1 and occludin.Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2,STAT3,p-JAK2,and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.DHA has a specific therapeutic effect on UC.The anti-inflammatory mechanism of DHA is related to the blockage of the JAK2/STAT3 signaling pathway.These findings provide evidence that DHA may be a useful drug and is expected to become a promising new treatment for human UC. | Mingrui Jiang Guangjun Zhong Yichao Zhu Liuhua Wang Yuzhe He Qiannan Sun Xiaoqing Wu Xiaolan You Sujun Gao Dong Tang Daorong Wang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 6 |
| 2 | A lightweight multidimensional index for complex queries over DHTs显示文摘 | Tang Yuzhe Xu Jianliang Zhou Shuigeng Lee Wangchien | 2011 | IEEE Transactions onParallel and Distributed Systems2011，22，12： | 1 |
| 3 | Characteristics and Mechanism of Upper Permian Reef Reservoirs in the Eastern Longgang Area, Northeastern Sichuan Basin, China显示文摘As a typical kind of lithologic reservoirs,reef reservoirs are generally featured by their large single-well reservoir thickness,good reservoir physical properties,and high gas well productivity.The Upper Permian Changxing Formation is an important natural gas exploration target in the Sichuan Basin,which hosts a large reef gas reservoir and is mainly distributed along the Kaijiang-Liangping Trough.Comprehensive analyses are implemented to investigate reservoir characteristics and identify controlling factors of reef reservoirs in Changxing Formation in the Eastern Longgang Area,Northeastern Sichuan Basin,including core,logging,and seismic data analyses.Changxing Formation reservoirs in the study area mainly occur in the reef-shoal complex,which are featured by wide distribution,large thickness and generally good physical properties.Reservoir rocks are dominantly composed of bioclastic dolomite and silty-fine dolomite(with grain phantom structure),while the main reservoir space consists of residual intergranular pores,intergranular dissolution pores,and karst vugs.In the seismic profiles,typical mound-shaped chaotic reflections can be clearly seen.It is suggested by the main reservoir development controlling factor analysis that the distributions of reef reservoirs are typically controlled by sedimentary facies belts,while the scale of the reef-shoal complex is determined by the pene-sedimentary micro-paleo-geomorphology.Dolomitization can not only significantly preserve the primary pores but also enhance the permeability of rocks.Moreover,karstification is the key to high-quality reef-shoal reservoirs. | Lei Tan Hong Liu Yuzhe Tang Bing Luo Ya Zhang Yuran Yang Yisha Liao Weifeng Du Xiran Yang | 2020 | Petroleum2020，6，2： | 1 |
| 4 | Privacy preserving multi-keyword search in information networks显示文摘 | TANG Yuzhe LIU Ling | 2015 | IEEE Transactions on Knowledge and Data Engineering2015，27，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员