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| 1 | Cyberknife treatment for advanced or terminal stage hepatocellular carcinoma显示文摘AIM: To investigate the safety and efficacy of the Cyberknife treatment for patients with advanced or terminal stage hepatocellular carcinoma(HCC).METHODS: Patients with HCC with extrahepatic metastasis or vascular or bile duct invasion were enrolled between May 2011 and June 2015. The Cyberknife was used to treat each lesion. Treatment response scores were based on Response Evaluation Criteria in Solid Tumors v1.1. The trends of tumor markers,including alpha fetoprotein(AFP) and proteins induced by vitamin K absence Ⅱ(PIVKA Ⅱ) were assessed. Prognostic factors for tumor response and tumor markers were evaluated with Fisher's exact test and a logistic regression model. Survival was evaluated with the Kaplan-Meier method and multivariate analysis was performed using the Cox proportional hazards model.RESULTS: Sixty-five patients with 95 lesions were enrolled. Based on the Barcelona Clinic Liver Cancer classification,all patients were either in the advanced or terminal stage of the disease. The target lesions were as follows: 52 were bone metastasis; 9,lung metastasis; 7,brain metastasis; 9,portal vein invasion;4,hepatic vein invasion; 4,bile duct invasion; and 10 other lesion types. The response rate and disease control rate were 34% and 53%,respectively. None of the clinical factors correlated significantly with tumor response. Fiducial marker implantation was associated with better control of both AFP(HR = 0.152; 95%CI: 0.026-0.887; P = 0.036) and PIVKA Ⅱ(HR = 0.035; 95%CI: 0.003-0.342; P = 0.004). The median survival time was 9 mo(95%CI: 5-15 mo). Terminal stage disease(HR = 9.809; 95%CI: 2.589-37.17,P < 0.001) and an AFP of more than 400 ng/m L(HR = 2.548; 95%CI: 1.070-6.068,P = 0.035) were associated with worse survival. A radiation dose higher than 30 Gy(HR = 0.274; 95%CI: 0.093-0.7541,P = 0.012) was associated with better survival. In the 52 cases of bone metastasis,36 patients(69%) achieved pain relief. One patient had cerebral bleeding and another patient had an esophageal ulcer after treatment.CONCLUSION: The Cyberknife can be safely administered to patients with advanced or terminal stage HCC. High AFP levels were associated with worse survival,but a higher radiation dose improved the survival. | Hiroyuki Kato Hideo Yoshida Hiroyoshi Taniguch Ryutaro Nomura Kengo Sato Ichiro Suzuki Ryo Nakata | 2015 | World Journal of Gastroenterology2015，21，46： | 3 |
| 2 | 显示文摘 | SHIMADAA T WEN C TANIGUCHIC N | 2004 | J Power Sources2004，131，： | 1 |
| 3 | Induction of aquaporin-4 water channel mRNA after focal cerebral ischemia in rat显示文摘 | Toshihide | 2000 | Molecular Brain Res2000，78，12： | 1 |
| 4 | Selective ion extraction by a calix arene derivative containing azo groups 显示文摘 | Nomura E Taniguche H Tamura S | 1989 | Chem Lett1989，，7： | 1 |
| 5 | Excision of a choledochal cyst and simultaneous hepatic lateral segmentectomy显示文摘 | Taniguch F Nakahara S Uno K Kawarasaki H Inoue Y Nishikawa J | 1996 | J Pediatr Surg Int1996，11，： | 1 |
| 6 | Associations of plasma C-reactive protein levels with the presence and extent of coronary stenosia in patients with stable coronary artery disease显示文摘 | Taniguch IH Momiyama Y Ohmori R | | 0，，01： | 1 |
| 7 | Application of Al2O3-MgO castable for high temperature operation steel ladel 显示文摘 | TAWARA M FUJII K TANIGUCH] T | 1995 | Refractories(Tokyo)1995，47，6： | 1 |
| 8 | Sustained high levels of circulatory interleukin-8 associated with a poor outcome in patients with adult respiratory distress syndrome显示文摘 | Ikuta N Taniguch I H Kondoh Y | 1996 | Intern Med1996，35，： | 1 |
| 9 | Structure and expression of acloned cDNA for human interleuk in 2显示文摘 | Taniguch I T | 1983 | Nature1983，，： | 1 |
| 10 | Determination of arsenite, ar- senate, and monomethylarsonic acid in seawater by ion-exclusion chro- matography combined with inductively coupled plasma mass spectrom- etry using reaction cell and hydride generation techniques 显示文摘 | Nakazato T Tao H Taniguch IT | 2002 | Talanta2002，58，： | 1 |
| 11 | Biological and chemical attributes of soils under forest species in Northeast Brazil显示文摘Timber forests contribute to the sustainable development of the biomes in tropical regions.The aim of this study was to evaluate the biological and chemical properties of the soil as a consequence of the cover with native and non-native species in the Acarau basin,a transition area from the coast to the Brazilian semi-arid region.Areas planted with four native species(Anadenanthera colubrina,Astronium fraxinifolium,Handroanthus impetiginosus,Colubrina glandulosa)and three exotic species(Acacia mangium,Casuarina equisetifolia,Eucalyptus urophylla)plus a non-forested agricultural area were evaluated for organic carbon contents,and microbial and chemical soil properties.The levels of soil organic carbon were highest in A.colubrina and C.equisetifolia plantations.Low basal soil respiration was observed but the microbial biomass was particularly low in the non-forested area.In the C.equisetifolia,E.urophylla,and H.impetiginosus plantations,elevated soil metabolic quotients were found.The A.colubrina and H.impetiginosus plantations had the highest levels of easily extracted-glomalin related soil protein.Tree species affect concentrations of essential nutrients and the biological quality of the soil in different ways.They can also improve the biological and chemical properties of the soil in the coastal plains of tropical regions. | Olmar Baller Weber Maria Catia Barroso da Silva Cristiane Figueira da Silva Joao Alencar de Sousa Carlos Alberto Kenji Taniguch Deborah dos Santos Garruti Ricardo Espindola Romero | 2020 | Journal of Forestry Research2020，31，5： | 1 |
| 12 | Systematic Analysis of Post Administrative Saiboku--Tourine by Liquid Chroma- tography to Determine Pharmacokinetics of Traditional Chinese Medicine显示文摘 | HommaM OkaK and TaniguchiC | 1997 | Biomed Chromatogr1997，11，3： | 1 |
| 13 | Effects of treadmill exercise on platelet functions and blood coagulating activities in healthy man 显示文摘 | Mammen EF Piek J | 1993 | Heart1993，51，1： | 1 |
| 14 | Induction pump for high-temperature molten metals using rotating twisted magnetic field显示文摘 | Ando T Ueno K Taniguch S | 2001 | Journal of Japan AEM Society2001，9，： | 1 |
| 15 | Induction of aquaporin-4 water channel mRNA after focal cerebral ischemia in rat显示文摘 | TANIGUCHE M YAMASHITA T KUMURA E | 2000 | Molecular Brain Res2000，78，12： | 1 |
| 16 | Sulfate resistance of high fly ash content concrete显示文摘 | TORI] K TANIGUCH] K KAWAMURA M | 1995 | Cement and Concrete Research1995，25，4： | 1 |
| 17 | Prognostic significance of T helper 1 and 2 and T cytotoxic 1 and 2 cells in patients with non-small cell lung cancer显示文摘 | ITO N SUZUKI Y TANIGUCH I Y | 2005 | Anticancer Res2005，25，3： | 1 |
| 18 | Es- trogen removal from treated municipal effluent in small- scale constructed wetland with different depth 显示文摘 | SONG Hai-Liang NAKANO K TANIGUCH T | 2009 | Biore- source Technology2009，100，： | 1 |
| 19 | Total and unconju-gated serum bile acid levels in patients with hepatobiliarydiseases显示文摘 | Makino IH Taniguch T Ishiya | 1969 | Nihon Naika Gakkai Zasshi1969，58，10： | 1 |
| 20 | Effects of propofol on hemodynamic and inflammatory responses to endo toxemia inrats显示文摘 | Taniguch T Yamamo K Ohmo N | 2000 | Crit Care Med2000，28，4： | 1 |
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