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| 1 | Effects of thymidine phosphorylase on tumor aggressiveness and 5-fluorouracil sensitivity in cholangiocarcinoma显示文摘AIM: To evaluate the role of thymidine phosphorylase (TP) in cholangiocarcinoma using small interfering RNA (siRNA). METHODS: A human cholangiocarcinoma-derived cell line KKU-M139, which has a naturally high level of endogenous TP, had TP expression transiently knocked down using siRNA. Cell growth, migration, in vitro angiogenesis, apoptosis, and cytotoxicity were assayed in TP knockdown and wild-type cell lines. RESULTS: TP mRNA and protein expression were decreased by 87.1% ± 0.49% and 72.5% ± 3.2%, respectively, compared with control cells. Inhibition of TP significantly decreased migration of KKU-M139, and suppressed migration and tube formation of human umbilical vein endothelial cells. siRNA also reduced the ability of TP to resist hypoxia-induced apoptosis, while suppression of TP reduced the sensitivity of KKU-M139 to 5-fluorouracil. CONCLUSION: Inhibition of TP may be beneficial in decreasing angiogenesis-dependent growth and migration of cholangiocarcinoma but may diminish the response to 5-fluorouracil chemotherapy. | Jongkonnee Thanasai Temduang Limpaiboon Patcharee Jearanaikoon Banchob Sripa Chawalit Pairojkul Srisurang Tantimavanich Masanao Miwa | 2010 | World Journal of Gastroenterology2010，16，13： | 2 |
| 2 | Detection of MNS hybrid molecules in the Thai population using PCR-SSP technique显示文摘 | Pa dacajornsuk P Nathalang O Tantimavanich S | | 0，，3： | 1 |
| 3 | Chitinase from Bacillus thuringiensis subsp, pakistani 显示文摘 | Thamthiankul S Suan-Ngay S Tantimavanich S | 2001 | Appl Microbiol Biotechnol2001，56，34： | 1 |
| 4 | HLA-B27 tes- ting in Thai patients using the PCR-SSP technique显示文摘 | Nathalang O Tantimavanich S Nillakupt K | 2006 | Tissue An tigens2006，67，3： | 1 |
| 5 | Multiple chitinasc enzymes from a single gent of Bacillus lichcniformis TP-1 显示文摘 | Tantimavanich S Pantnwatana S Bhumiratana A | 1998 | Journal of Fermentation and Bioengineering1998，85，3： | 1 |
| 6 | Chitinase from Bacillus thuringiensis subsp. pakistani显示文摘 | S. Thamthiankul S. Suan-Ngay S. Tantimavanich W. Panbangred | 2001 | Applied Microbiology and Biotechnology (-)2001，，3： | 1 |
| 7 | Multiple chitinase enzymes from a single gene of Bacillus licheniformis TP-1显示文摘 | Tantimavanich S Pantuwatana S | 1998 | J Ferment Bioeng1998，85，3： | 1 |
| 8 | Multiple Chitinase Enzymes from a SingleGene of Bacillus Licheniformis TP-1 显示文摘 | TANTIMAVANICH S PANTUWATANA S BHUMIRATANA A | 1998 | Journal of Fermentation and Bioengineering1998，85，3： | 1 |
| 9 | Chitinase from Bacillus thuringiensis subsp, pakistani 显示文摘 | THAMTHIANKUL S SUAN-NGAY S TANTIMAVANICH S | 2001 | Appl Microbiol Biotechnol2001，56，： | 1 |
| 10 | Cloning of chitinase gene into Bacillus thuringiensis subsp, aizawai for enhanced insecticidal activity显示文摘 | Tantimavanich S Pantuwatana S Bhumiratana A | 1997 | J Gen Appl Microbiol1997，43，： | 1 |
| 11 | Chitinase from Bacillus thuringiensis subsp, pakistani 显示文摘 | Thamthiankul S Suan - Ngay S Tantimavanich S | 2001 | Appl Micrebiol Bioteehnol2001，56，34： | 1 |
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