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| 1 | Continuous Action Reinforcement Learning for Control-Affine Systems with Unknown Dynamics显示文摘Control of nonlinear systems is challenging in realtime.Decision making,performed many times per second,must ensure system safety.Designing input to perform a task often involves solving a nonlinear system of differential equations,which is a computationally intensive,if not intractable problem.This article proposes sampling-based task learning for controlaffine nonlinear systems through the combined learning of both state and action-value functions in a model-free approximate value iteration setting with continuous inputs.A quadratic negative definite state-value function implies the existence of a unique maximum of the action-value function at any state.This allows the replacement of the standard greedy policy with a computationally efficient policy approximation that guarantees progression to a goal state without knowledge of the system dynamics.The policy approximation is consistent,i.e.,it does not depend on the action samples used to calculate it.This method is appropriate for mechanical systems with high-dimensional input spaces and unknown dynamics performing Constraint-Balancing Tasks.We verify it both in simulation and experimentally for an Unmanned Aerial Vehicles(UAVs) carrying a suspended load,and in simulation,for the rendezvous of heterogeneous robots. | Aleksandra Faust Peter Ruymgaart Molly Salman Rafael Fierro Lydia Tapia | 2014 | IEEE/CAA Journal of Automatica Sinica2014，1，3： | 3 |
| 2 | Brain metastasis in advanced colorectal cancer: results from the South Australian metastatic colorectal cancer (SAmCRC) registry显示文摘Objective:Brain metastasis is considered rare in metastatic colorectal cancer(mCRC);thus,surveillance imaging does not routinely include the brain.The reported incidence of brain metastases ranges from 0.6% to 3.2%.Methods:The South Australian mCRC Registry(SAmCRC)was analyzed to assess the number of patients presenting with brain metastasis during their lifetime.Due to small numbers,a descriptive analysis is presented.Results:Only 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis(1.4%).The clinical characteristics of those with brain metastasis were as follows:the median age was 65.3 years and 51% were female.Where the V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)mutation status of the tumor was known,the majority harbored a KRAS mutation(55%);31(53%)underwent craniotomy and 55(93%)underwent whole-brain radiotherapy.The median survival time from diagnosis of brain metastasis was 4.2 months(95% confidence interval 2.9–5.5).Patients who underwent craniotomy and radiotherapy had superior survival compared to those who underwent whole-brain radiotherapy(8.5 months vs.2.2 months,respectively).Data from the SAmCRC(a population-based registry)confirm that brain metastases are rare and the median time to development is approximately 2 years.Conclusions:Brain metastasis is a rare outcome in advanced CRC.Patients within the registry tended to be female,young in age,and harbored with higher rates of KRAS mutations.Whether routine surveillance brain scanning should be considered remains controversial given the relative rarity of developing brain metastases in mCRC and ultimately,most patients with central nervous system involvement die from their extracranial disease. | Gonzalo Tapia Rico Timothy J. Price Christos Karapetis Cynthia Piantadosi Rob Padbury Amitesh Roy Guy Maddern James Moore Scott Carruthers David Roder Amanda R. Townsend | 2017 | Cancer Biology & Medicine2017，14，4： | 3 |
| 3 | Abrupt onset of diabetes during interferon‐alpha therapy in patients with chronic hepatitis C显示文摘 | M.Recasens E.Aguilera S.Ampurdanés J. M.Sánchez Tapias O.Simó R.Casamitjana I.Conget | 2008 | Diabetic Medicine2008，，9： | 2 |
| 4 | Protective effect of sulforaphane pretreatment against cisplatin-induced liver and mitochondrial oxidant damage in rats显示文摘 | Leobardo Gaona-Gaona Eduardo Molina-Jijón Edilia Tapia Cecilia Zazueta Rogelio Hernández-Pando Mariel Calderón-Oliver Guillermo Zarco-Márquez Enrique Pinzón José Pedraza-Chaverri | 2011 | Toxicology2011，，1： | 2 |
| 5 | Effect of the exposure angle in the corrosion rate of plain carbon steel in a marine atmosphere显示文摘 | R. Vera B.M. Rosales C. Tapia | 2002 | Corrosion Science2002，，2： | 2 |
| 6 | 在肝 preconditioning 的最近的进展: 甲状腺荷尔蒙, n-3 长链的多元不堡和丰满的酸和熨斗显示文摘 Liver preconditioning (PC), defined as an enhanced tolerance to injuring stimuli induced by previous specific maneuvers triggering beneficial functional and molecular changes, is of crucial importance in human liver transplantation and major hepatic resection. For these reasons, numerous PC strategies have been evaluated in experimental models of ischemia-reperfusion liver injury, which have not been transferred to clinical application due to side effects, toxicity and difficulties in implementation, with the exception of the controversial ischemic PC. In recent years, our group has undertaken the assessment of alternate experimental liver PC protocols that might have application in the clinical setting. These include thyroid hormone (T3), n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA), or iron, which suppressed liver damage due to the 1 h ischemia-20 h reperfusion protocol. T3, n-3 LCPUFA and iron are hormetic agents that trigger biologically beneficial effects in the low-dose range, whose multifactorial mechanisms of action are discussed in the work. | Virginia Fernández Gladys Tapia Luis A Videla | 2012 | World Journal of Hepatology2012，4，4： | 2 |
| 7 | Lysine Acetylation and Deacetylation in Brain Development and Neuropathies显示文摘Embryonic development is critical for the final functionality and maintenance of the adult brain. Brain development is tightly regulated by intracellular and extracellular signaling.Lysine acetylation and deacetylation are posttranslational modifications that are able to link extracellular signals to intracellular responses. A wealth of evidence indicates that lysine acetylation and deacetylation are critical for brain development and functionality. Indeed, mutations of the enzymes and cofactors responsible for these processes are often associated with neurodevelopmental and psychiatric disorders. Lysine acetylation and deacetylation are involved in all levels of brain development, starting from neuroprogenitor survival and proliferation, cell fate decisions, neuronal maturation, migration, and synaptogenesis, as well as differentiation and maturation of astrocytes and oligodendrocytes, to the establishment of neuronal circuits. Hence, fluctuations in the balance between lysine acetylation and deacetylation contribute to the final shape and performance of the brain. In this review, we summarize the current basic knowledge on the specific roles of lysine acetyltransferase(KAT) and lysine deacetylase(KDAC) complexes in brain development and the different neurodevelopmental disorders that are associated with dysfunctional lysine(de)acetylation machineries. | Alicia Tapias Zhao-Qi Wang | 2017 | Genomics, Proteomics & Bioinformatics2017，15，1： | 2 |
| 8 | Plasma interferon - gamma, interleukin - 10 and soluble markers of immune activation in infants with primary adenovirus ( ADV ) and respiratory syneytial virus ( RSV ) infection显示文摘 | Femdndez JA Tapia L Palomino MA | 2005 | Eur Cytokine Netw2005，16，1： | 1 |
| 9 | Mod- eling and control of a wind turbine driven doubly fed induction generator 显示文摘 | TAPIA A TAPIA G OSTOLAZA J X SAENZ J R | 2003 | IEEE Transactions on Energy Conversion2003，18，2： | 1 |
| 10 | Glutamic acid and Alzheimer's disease显示文摘 | Arias CB Garcia F Tapia R | 1998 | Neurobiology1998，6，2： | 1 |
| 11 | Diaphragmmatil hernia after transshiatal esophagectomy 显示文摘 | Tapia DJ Sanchez R Moreno M | 2000 | Rec Esp Anestesiol Reamin2000，7，2： | 1 |
| 12 | Using polysac- charide-based edible coatings to maintain quality of fresh-cut Fuji apples显示文摘 | RojasGraii M A Tapia M S Martin-Bellosoa O | 2008 | LWT Food Science and Technology2008，41，： | 1 |
| 13 | Effect of 13-epi-Sclareol on the Bacterial Respiratory Chain 显示文摘 | Tapia L Torres J Mendoza L | 2004 | Planta Medica2004，70，11： | 1 |
| 14 | Influence of hepatitis B genotype on the long -term outcome of chron- ic hepatitis B in western patients 显示文摘 | SaNCHEZ -TAPIAS JM COSTA J MAS A | 2002 | Gastroenterology2002，123，6： | 1 |
| 15 | Influence of implant length, diameter, and geometry on stress distribution: a finite ele- ment analysis显示文摘 | Anitua E Tapia R Luzuriaga F | 2010 | Int J Periodontics Restorative Dent2010，30，1： | 1 |
| 16 | Effect of rosuvastatin on cytokines after traumatic head injury显示文摘 | Sánchez Aguilar M Tapia Pérez J H Sánchez Rodríguez J J | 2013 | J Neurosurg2013，118，3： | 1 |
| 17 | Jejunostomy: techniques, indication, and complications 显示文摘 | Tapia J Murguia R Garcia G | 1999 | World J Surg1999，23，6： | 1 |
| 18 | Immunogenicity of the pentavalent rotavirus vaccine in African infants显示文摘 | George E. Armah Robert F. Breiman Milagritos D. Tapia Michael J. Dallas Kathleen M. Neuzil Fred N. Binka Samba O. Sow Joel Ojwando Max Ciarlet A. Duncan Steele | 2012 | Vaccine2012，，： | 1 |
| 19 | Numerical experience with a polyhedral-norm CDT trust-region algorithm显示文摘 | M. M. El-Alem R. A. Tapia | 1995 | Journal of Optimization Theory and Applications1995，，3： | 1 |
| 20 | Effects offebuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome 显示文摘 | S6nchez-Lx)zada LG Tapia E Bautista-Garcia P | 2008 | Am J Physiol Renal Physiol2008，294，4： | 1 |
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