|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn’s disease显示文摘AIM: To investigate the frequency of the common NOD2/CARD15 susceptibility variants and two functional polymorphisms of OCTN cation transporter genes in Hungarian pediatric patients with Crohn’s disease (CD). METHODS: A cohort of 19 unrelated pediatric and 55 unrelated adult patients with Crohn’s disease and 49 healthy controls were studied. Genotyping of the three common CD-associated CARD15 variants (Arg702Trp, Gly908Arg and 1007finsC changes) with the SLC22A4 1672C→T, and SLC22A5 -207G→C mutations was performed by direct sequencing of the specifi c regions of these genes.RESULTS: At least one CARD15 mutation was present in 52.6% of the children and in 34.5% of the adults compared to 14.3% in controls. Surprisingly, strongly different mutation profi le was detected in the pediatric versus adult patients. While the G908R and 1007finsC variants were 18.4% and 21.1% in the pediatric group, they were 1.82% and 11.8% in the adults, and were 1.02% and 3.06% in the controls, respectively. The R702W allele was increased approximately two-fold in the adult subjects, while in the pediatric group it was only approximately 64% of the controls (9.09% in the adults, 2.63% in pediatric patients, and 4.08% in the controls). No accumulation of the OCTN variants was observed in any patient group versus the controls.CONCLUSION: The frequency of the NOD2/CARD15 susceptibility variants in the Hungarian pediatric CD population is high and the profile differs from the adult CD patients, whereas the results for SLC22A4 and SLC22A5 mutation screening do not confirm the assumption that the carriage of these genotypes means an obligatory susceptibility to CD. | Judit Bene Lili Magyari Gábor Talián Katalin Komlósi Beáta Gasztonyi Beáta Tari gnes Várkonyi Gyula Mózsik Béla Melegh | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 2 | Glutathione transferase supergene family in tomato: Salt stress-regulated expression of representative genes from distinct GST classes in plants primed with salicylic acid显示文摘 | Jolán Csiszár Edit Horváth Zsolt Váry ágnes Gallé Krisztina Bela Szilvia Brunner Irma Tari | 2014 | Plant Physiology and Biochemistry2014，，： | 1 |
| 3 | Workaholism, Burnout, and Work Engagement: Three of a Kind or Three Different Kinds of Employee Well-being? 显示文摘 | Schaufeli W B Taris T W Rhenen W V | 2008 | Applied Psychology2008，57，2： | 1 |
| 4 | Cyclooxygenase-2 utilizes Jun N-terminal kinases to induce invasion, but not tamoxifen resistance, in MCF-7 breast cancer cells显示文摘 | Gonzalez-Villasana V Guti6rrez-Puente Y Tari AM | 2013 | Oncol Rep2013，30，3： | 1 |
| 5 | Failure analysis of ethylene cracking tube 显示文摘 | Tari V Najafizadeh A Aghaei M | 2009 | Journal of Failure Analysis and Prevention2009，9，4： | 1 |
| 6 | Performance analysis of EDF scheduling in a multi-priority preemptive M/G/1queue显示文摘 | Abhaya V G Tari Z Zeephongsekul P | 2013 | IEEE Transactions on Parallel and Distributed Systems2013，25，8： | 1 |
| 7 | The cytokine signature of MOG specific CD4 cells in the EAE of C57BL/6 mice显示文摘 | Hofstetter H H Karulin A Y Forsthuber T G Ott P A Tary Lehmann M Lehmann P V | 2005 | J Neuroimmunol2005，170，： | 1 |
| 8 | Functional and structural measurements for the assessment of internal limiting membrane peeling in idiopathic macular pucker显示文摘 | TARI S R VIDNE-HAY O GREENSTEIN V C | 2007 | Retina2007，27，5： | 1 |
| 9 | Failure analysis of ethylene cracking tube 显示文摘 | Tari V Najafizadeh A Aghaei M H | 2009 | Journal of Failure Analysis and Prevention2009，5，4： | 1 |
| 10 | Failure Analy-sis of Ethylene Cracking Tube显示文摘 | Tari V Najafizadeh A Aghaei M | | 0，，04： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员