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| 1 | Utility of computed tomography in identifying an ectopic thyroid in infants and pre-school children显示文摘 | KOBAYASHI H TASHITA H HARA H | 2005 | Endocr J2005，52，： | 1 |
| 2 | Pharmacokinetic analysis of antiplatelet effect of sarpogrelate hydrochloride and its application to drug dosage regimen-modeling based on reversible inhibition of 5-HT2 serotonergic receptor in the platelet membrane by sarpogrelate hydrochloride and its metabolite显示文摘 | Shimizu T Yamada Y Tashita A | 1999 | Yakugaku Zasshi1999，19，11： | 1 |
| 3 | Ultrasound-mediated drug delivery using liposomes modified with a thermosensitive polymer显示文摘 | Ninomiya K Kawabata S Tashita H | 2014 | Ultrason Sonochem2014，21，1： | 1 |
| 4 | Ultrasound-mediated drug delivery using liposomes modified with a thermosensitive polymer显示文摘 | Ninomiya K Kawabata S Tashita H | 2014 | Ultrason Sonochem2014，21，1： | 1 |
| 5 | Microphase separated structure, surface composition and blood compatibility of segmented polyurethaneureas with various soft segment components 显示文摘 | Takahara A Tashita J Kajiyana T | 1985 | Polymer1985，26，： | 1 |
| 6 | Serum IgE level is negatively correlated with the ability of peripheral mononuclear cells to produce interferon gamma (IFNgamma): Evidence of reduced expression of IFNgamma mRNA in atopic patients显示文摘 | Fukao T Tashita H | 1998 | Clin Exp Allergy1998，28，1： | 1 |
| 7 | Ultrasound-mediated drug delivery using liposomes modified with a thermosensitive poly- mer 显示文摘 | Ninomiya K Kawabata S Tashita H | 2014 | Ultrason Sonochem2014，21，1： | 1 |
| 8 | Ultrasound-mediated drug delivery using liposomes modified with a thermosensitive polymer显示文摘 | Ninomiya K Kawabata S Tashita H | 2014 | Ultrasonics sonochemistry2014，21，1： | 1 |
| 9 | Long-length IBAD-MgO Buffer Layers for High Performance RE-123 Coated Conductors by a Large Ion Beam Source显示文摘 | Hanyu S Tashita C Hayashida T | 2010 | Physica C''Supercon-ductivity2010，470，20： | 1 |
| 10 | Effect of aggregation stae of hard segment in segmented poly (urethaneureas) on their fatigue behavior after interaction with blood components 显示文摘 | TAKAHARA A TASHITA Jun-ichi KAJIYAMA T | 1985 | J Biomed Mater Res1985，19，1： | 1 |
| 11 | Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice显示文摘BACKGROUND Inflammatory bowel disease,such as Crohn’s disease and ulcerative colitis,is characterized by chronic intestinal inflammation leading to intestinal mucosal damage.Inflammatory bowel disease causes dysregulation of mucosal T cell responses,especially the responses of CD4+T cells.Previously,we demonstrated that indoleamine-2,3-dioxygenase plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate(TNBS)-induced colitis.Although indoleamine-2,3-dioxygenase exerts immunosuppressive effects by altering the local concentration of tryptophan(Trp)and immunomodulatory Trp metabolites,the specific changes in immune regulation during colitis caused by Trp metabolites and its related enzymes remain unclear.AIM To investigate role of kynurenine 3-monooxygenase(KMO)in TNBS-induced colitis and involvement of Trp metabolites in maintenance of intestinal homeostasis.METHODS Colitis was induced in eight-week-old male KMO+/+or KMO−/−mice of C57BL/6N background using TNBS.Three days later,the colon was used for hematoxylin-eosin staining for histological grading,immunohistochemical or immunofluorescence staining for KMO,cytokines,and immune cells.Inflammatory and anti-inflammatory cytokines were measured using quantitative RT-PCR,and kynurenine(Kyn)pathway metabolites were measured by high-performance liquid chromatography.The cell proportions of colonic lamina propria and mesenteric lymph nodes were analyzed by flow cytometry.RESULTS KMO expression levels in the colonic mononuclear phagocytes,including dendritic cells and macrophages increased upon TNBS induction.Notably,KMO deficiency reduced TNBS-induced colitis,resulting in an increased frequency of Foxp3+regulatory T cells and increased mRNA and protein levels of antiinflammatory cytokines,including transforming growth factor-βand interleukin-10.CONCLUSION Absence of KMO reduced TNBS-induced colitis via generation of Foxp3+regulatory T cells by producing Kyn.Thus,Kyn may play a therapeutic role in colon protection during colitis. | Chieko Tashita Masato Hoshi Akihiro Hirata Kentaro Nakamoto Tatsuya Ando Takayuki Hattori Yasuko Yamamoto Hiroyuki Tezuka Hiroyuki Tomita Akira Hara Kuniaki Saito | 2020 | World Journal of Gastroenterology2020，26，9： | 1 |
| 12 | High-speed deposition of high-quality RE123 films by a PLD system with hot-wallheating显示文摘 | K Kakimoto M Igarashi Y Hanada T Hayashida C Tashita K Morita S Hanyu Y Sutoh H Kutami Y Iijima T Saitoh | 2010 | Superconductor Science and Technology2010，，1： | 1 |
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