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| 1 | Sleep,immunity and inflammation in gastrointestinal disorders显示文摘Sleep disorders have become a global issue,and discovering their causes and consequences are the focus of many research endeavors.An estimated 70 million Americans suffer from some form of sleep disorder.Certain sleep disorders have been shown to cause neurocognitive impairment such as decreased cognitive ability,slower response times and performance detriments.Recent research suggests that individuals with sleep abnormalities are also at greater risk of serious adverse health,economic consequences,and most importantly increased all-cause mortality.Several research studies support the associations among sleep,immune function and inflammation.Here,we review the current research linking sleep,immune function,and gastrointestinal diseases and discuss the interdependent relationship between sleep and these gastrointestinal disorders.Different physiologic processes including immune system and inflammatory cytokines help regulate the sleep.The inflammatory cytokines such as tumor necrosis factor,interleukin-1(IL-1),and IL-6 have been shown to be a significant contributor of sleep disturbances.On the other hand,sleep disturbances such as sleep deprivation have been shown to up regulate these inflammatory cytokines.Alterations in these cytokine levels have been demonstrated in certain gastrointestinal diseases such as inflammatory bowel disease,gastro-esophageal reflux,liver disorders and colorectal cancer.In turn,abnormal sleep brought on by these diseases is shown to contribute to the severity of these same gastrointestinal diseases.Knowledge of these relationships will allow gastroenterologists a great opportunity to enhance the care of their patients. | Tauseef Ali James Choe Ahmed Awab Theodore L Wagener William C Orr | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 2 | Environmental risk factors for inflammatory bowel diseases: Evidence based literature review显示文摘AIM: To advances in genetics and immunology have contributed to the current understanding of the pathogenesis of inflammatory bowel diseases(IBD). METHODS: The current opinion on the pathogenesis of IBD suggests that genetically susceptible individuals develop intolerance to dysregulated gut microflora(dysbiosis) and chronic inflammation develops as a result of environmental insults. Environmental exposures are innumerable with varying effects during the life course of individuals with IBD. Studying the relationship between environmental factors and IBD may provide the missing link to increasing our understanding of the etiology and increased incidence of IBD in recent years with implications for prevention, diagnosis, and treatment. Environmental factors are heterogeneous and genetic predisposition, immune dysregulation, or dysbiosis do not lead to the development of IBD in isolation. RESULTS: Current challenges in the study of environmental factors and IBD are how to effectively translate promising results from experimental studies to humans in order to develop models that incorporate the complex interactions between the environment, genetics, immunology, and gut microbiota, and limited high quality interventional studies assessing the effect of modifying environmental factors on the natural history and patient outcomes in IBD.CONCLUSION: This article critically reviews the current evidence on environmental risk factors for IBD and proposes directions for future research. | Ayokunle T Abegunde Bashir H Muhammad Owais Bhatti Tauseef Ali | 2016 | World Journal of Gastroenterology2016，22，27： | 11 |
| 3 | Iron deficiency anemia in inflammatory bowel disease显示文摘Anemia is a common extraintestinal manifestation of inflammatory bowel disease(IBD) and is frequently overlooked as a complication. Patients with IBD are commonly found to have iron deficiency anemia(IDA) secondary to chronic blood loss, and impaired iron absorption due to tissue inflammation. Patients with iron deficiency may not always manifest with signs and symptoms; so, hemoglobin levels in patients with IBD must be regularly monitored for earlier detection of anemia. IDA in IBD is associated with poor quality of life, necessitating prompt diagnosis and appropriate treatment. IDA is often associated with inflammation in patients with IBD. Thus, commonly used labora-tory parameters are inadequate to diagnose IDA, and newer iron indices, such as reticulocyte hemoglobin content or percentage of hypochromic red cells or zinc protoporphyrin, are required to differentiate IDA from anemia of chronic disease. Oral iron preparations are available and are used in patients with mild disease activity. These preparations are inexpensive and con-venient, but can produce gastrointestinal side effects, such as abdominal pain and diarrhea, that limit their use and patient compliance. These preparations are partly absorbed due to inflammation. Non-absorbed iron can be toxic and worsen IBD disease activity. Although cost-effective intravenous iron formulations are widely available and have improved safety profiles, physicians are reluctant to use them. We present a review of the pathophysiologic mechanisms of IDA in IBD, improved diagnostic and therapeutic strategies, efficacy, and safety of iron replacement in IBD. | Sindhu Kaitha Muhammad Bashir Tauseef Ali | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，3： | 3 |
| 4 | Preventive health measures in inflammatory bowel disease显示文摘We aim to review the literature and provide guidance on preventive health measures in inflammatory bowel disease(IBD). Structured searches were performed in Pub Med,MEDLINE,EMBASE,Web of Science and Cochrane Library from January 1976 to June 2016 using the following keywords:(inflammatory bowel disease OR Crohn's disease OR ulcerative colitis) AND(health maintenance OR preventive health OR health promotion). Abstracts of the articles selected from each of these multiple searches were reviewed,and those meeting the inclusion criteria(that is,providing data regarding preventive health or health maintenance in IBD patients) were recorded. Reference lists from the selected articles were manually reviewed to identify further relevant studies. Patients with IBD are at increased risk of developing adverse events related to the disease course,therapeutic interventions,or non-adherence to medication. Recent studies have suggested that IBD patients do not receive preventive services with the same thoroughness as patients with other chronic diseases. Preventive health measures can avert morbidity and improve the quality of life of patients with IBD. Gastroenterologists and primary care physicians(PCPs) should have an up to date working knowledge of preventive health measures for IBD patients. A holistic approach and better communication between gastroenterologists and PCPs with explicit clarification of roles will prevent duplication of services and streamline care. | Ayokunle T Abegunde Bashir H Muhammad Tauseef Ali | 2016 | World Journal of Gastroenterology2016，22，34： | 2 |
| 5 | Updates in vaccination:Recommendations for adult inflammatory bowel disease patients显示文摘Treatment regimens for inflammatory bowel disease(IBD) incorporate the use of a variety of immunosuppressive agents that increase the risk of infections.Prevention of many of these infections can be achieved by the timely and judicious use of vaccinations.IBD patients tend to be under-immunized.Some of the contributing factors are lack of awareness regarding the significance of vaccinating IBD patients,misperception about safety of vaccinations in immunocompromised patients,ambiguity about the perceived role of the gastroenterologist in contrast to the primary care physician and unavailability of vaccination guidelines focused on IBD population.In general,immunocompetent IBD patients can be vaccinated using standard vaccination recommendations.However there are special considerations for IBD patients receiving immunosuppressive therapy,IBD travelers and pregnant women with IBD.This review discusses current vaccination recommendations with updates for adult IBD patients.Centers for Disease Control and Prevention 2013 vaccination guidelines with 2014 updates and the Advisory Committee on Immunization Practices recommendations have been highlighted as a primary source of recommendations. | Khadija Chaudrey Michelle Salvaggio Aftab Ahmed Sultan Mahmood Tauseef Ali | 2015 | World Journal of Gastroenterology2015，21，11： | 2 |
| 6 | Risk of post-operative complications associated with anti-TNF therapy in inflammatory bowel disease显示文摘There have been increasing concerns regarding the safety of perioperative anti-tumour necrosis factor (anti-TNF) α agents. We performed a literature review to evaluate the post-operative complications associated with perioperative anti-TNF use in patients with inflammatory bowel disease. A comprehensive review was performed with a literature search utilizing Pub Med, Cochrane, OVID and EMBASE databases according to published guidelines. To date, there are only data for infliximab. There are three published studies which have assessed post-operative complications with perioperative infliximab use in patients with Crohn' s disease (CD), four studies in ulcerative colitis (UC) patients, and one study on both CD and UC patients. Two out of the three studies in CD patients showed no increased post-operative complications associated with perioperative infliximab. Two out of four studies in UC patients also did not show an increase in post-operative complications, and the combined study with CD and UC patients did not show an increased risk as well. Studyresults could not be combined secondary to significant differences in study designs, patient population and definition of their endpoints. There appears to be a risk of post-operative complications associated with TNF therapy in some patients. Based on these data, careful patient selection and prospective data collection should be performed. | Tauseef Ali Laura Yun David T Rubin | 2012 | World Journal of Gastroenterology2012，18，3： | 2 |
| 7 | Osteoporosis in Inflammatory Bowel Disease显示文摘 | Tauseef Ali David Lam Michael S. Bronze Mary Beth Humphrey | 2009 | The American Journal of Medicine2009，，7： | 2 |
| 8 | Clinical use of anti-TNF therapy and increased risk of infections显示文摘 | Tauseef Ali Kaitha Bronze Stone Ftaisi Mahmood | 2013 | Drug Healthcare and Patient Safety (default)2013，，： | 1 |
| 9 | 磁辐射3D非稳态流动体系的传热强化:Al和γ-Al2O3纳米粒子的对比研究(英文)显示文摘本文研究了水和乙二醇基纳米流体的胶体性质。考虑了洛伦兹力和热辐射的影响,通过相似变化,完成了控制方程的无量纲转化。然后,应用龙格-库塔法,对流动模型的非线性特性进行数值分析,对有关流速、温度、流线、等温线等流动参数的特性进行图解分析。结果表明,洛伦兹力有利于旋转速度,不利于其他旋转参数。体积分数和热辐射参数对Al和γ-Al2O3纳米流体的温度有正相关强化作用。此外,对于较高的旋转参数,研究其反向流动问题。与文献结果进行了比较,结果显示具有较高的吻合度。旋转有利于流体的流动速度,辐射流体越多,流体温度越高,而且体积分数的增加提高了热导率和电导率。 | Naveed AHMED ADNAN Umar KHAN Syed Zulfiqar Ali ZAIDI Imran FAISAL Syed Tauseef MOHYUD-DIN | 2019 | Journal of Central South University2019，26，5： | 1 |
| 10 | 43 Poor Sleep Quality Predicts Disease Relapse in Patients With Inflammatory Bowel Disease显示文摘 | Tauseef Ali Mohammad F. Madhoun Amber Crosby William C. Orr David T. Rubin | 2013 | Gastroenterology2013，，5： | 1 |
| 11 | Viral Infections in Patients With Inflammatory Bowel Disease on Immunosuppressants显示文摘 | Tauseef Ali Laura Yun David Shapiro Mohammad F. Madhoun Michael Bronze | 2012 | The American Journal of the Medical Sciences2012，，： | 1 |
| 12 | On biological population model of fractional order显示文摘 | Syed Tauseef Mohyud-Din Ayyaz Ali Bandar Bin-Mohsin | 2016 | International Journal of Biomathematics2016，9，5： | 1 |
| 13 | Long-term Safety Concerns with Proton Pump Inhibitors显示文摘 | Tauseef Ali David Neil Roberts William M. Tierney | 2009 | The American Journal of Medicine2009，，10： | 1 |
| 14 | New developments in gastroesophageal reflux disease diagnosis and therapy显示文摘 | Tauseef Ali Philip B Miner | 2008 | Current Opinion in Gastroenterology2008，，4： | 1 |
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