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| 1 | Methodological issues in the study of intestinal microbiota in irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS) is an intestinal functional disorder with the highest prevalence in the industrialized world. The intestinal microbiota(IM) plays a role in the pathogenesis of IBS and is not merely a consequence of this disorder. Previous research efforts have not revealed unequivocal microbiological signatures of IBS, and the experimental results are contradictory. The experimental methodologies adopted to investigate the complex intestinal ecosystem drastically impact the quality and significance of the results. Therefore, to consider the methodological aspects of the research on IM in IBS, we reviewed 29 relevant original research articles identified through a PubMed search using three combinations of keywords: 'irritable bowel syndrome + microflora', 'irritable bowel syndrome + microbiota' and 'irritable bowel syndrome + microbiome'. For each study, we reviewed the quality and significance of the scientific evidence obtained with respect to the experimental method adopted. The data obtained from each study were compared with all considered publications to identify potential inconsistencies and explain contradictory results. The analytical revision of the studies referenced in the present review has contributed to the identification of microbial groups whose relative abundance significantly alters IBS, suggesting that these microbial groups could be IM signatures for this syndrome. The identification of microbial biomarkers in the IM can be advantageous for the development of new diagnostic tools and novel therapeutic strategies for the treatment of different subtypes of IBS. | Valentina Taverniti Simone Guglielmetti | 2014 | World Journal of Gastroenterology2014，20，27： | 10 |
| 2 | Effects of undigested protein-rich ingredients on polarised small intestinal organoid monolayers显示文摘Here, we describe the use of monolayers of intestinal epithelial cells derived from intestinal organoids and transcriptomics to investigate the direct effects of dietary protein sources on epithelial function. Mechanically dissociated 3 D organoids of mouse duodenum were used to generate a polarized epithelium containing all cell types found in the tissue of origin. The organoid-derived cell monolayers were exposed to 4%(w/v) of ‘undigested(non-hydrolysed)-soluble' fraction of protein sources used as feed ingredients [soybean meal(SBM) and casein], or alternative protein sources(spray dried plasma protein, and yellow meal worm), or controls for 6 h prior to RNA isolation and transcriptomics. All protein sources altered expression of unique biological processes in the epithelial cells. Exposure of intestinal organoids to SBM downregulated expression of retinol and retinoid metabolic processes as well as cholesterol and lipid biosynthetic pathways, consistent with the reported hypotriglyceridaemic effect of soy protein in vivo. These findings support the use of intestinal organoids as models to evaluate complex interactions between dietary ingredients and the intestinal epithelium and highlights some unique host effects of alternative protein sources in animal feed and potentially human food. | Soumya K.Kar Bart van der Hee Linda M.P.Loonen Nico Taverne Johanna J.Taverne-Thiele Dirkjan Schokker Mari A.Smits Alfons J.M.Jansman Jerry M.Wells | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 3 |
| 3 | Two-photon lithography for 3D magnetic nanostructure fabrication显示文摘铁磁性的材料作为在数据存储设备记录媒介许多十年被利用了。到一架二维的飞机的材料的监禁是在完成超离频的记录的一个重要瓶颈密度,和这导致了提议三维(3D ) 利用领域的跑道记忆沿着 nanowires 围繁殖。然而,复杂几何学的磁性的 nanostructures 高度容易正在质问并且不是的 3D 的制造与标准平版印刷术技术完成了。这里,我们表明一条新途径构造 3D 用二光子的平版印刷术和电气化学的免职的联合的复杂几何学的磁性的 nanostructures。磁性被发现是亲密地,与结构,和磁性的成像的 3D 几何学有关,实验提供领域墙在 3D nanostructured 连接卡住的证据。 | Gwilym Williams Matthew Hunt Benedikt Boehm Andrew May Michael Taverne Daniel Ho Sean Giblin Dan Read John Rarity Rolf Allenspach Sam Ladak | 2018 | Nano Research2018，11，2： | 3 |
| 4 | Genetic polymor- phisms related to the renin-angiotensin-aldosterone system and response to antihypertensive drugs显示文摘 | Taverne K de Groot M de Boer A | 2010 | Expert Opin Drug Metab Toxicol2010，6，4： | 1 |
| 5 | Phar- macokinetics of morphine cerebrospinal fluid and plasma after epidural administration in man 显示文摘 | DROST R H IONESCU T I TAVERNE R H | 1988 | Arzneimittelforsehung1988，38，11： | 1 |
| 6 | Peripartum acute-phase protein serum arnyloid-A concentration in plasma of cows and fetuses显示文摘 | ALSEMGEEST S P TAVERNE M A M BOOSMAN R | 1993 | Amy Vet Res1993，54，： | 1 |
| 7 | Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-1ipoxygenase inhibitor显示文摘 | Barbey S Goossens L Taverne T | 2002 | Bioorg Med Chem Lett2002，12，5： | 1 |
| 8 | 肾素血管紧张素系统抑制剂与高血压患者新型冠状病毒肺炎易感性的关系:一项初级保健倾向评分匹配的队列研究显示文摘肾素血管紧张素系统(renin-angiotensin system,RAS)抑制剂被认为影响严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome coronavirus-2,SARS-CoV-2)的易感性。本研究调查高血压患者处方与新型冠状病毒肺炎(新冠肺炎)的发病率和全因死亡率之间是否存在关联。方法:研究者在英国大型初级保健数据库(健康改善网络)中进行了一项倾向得分匹配的队列研究. | 刘青(摘译) 郑武洪(审校) Haroon S Subramanian A Cooper J Anand A Gokhale K Byne NDhalla S Acosta-Mena D Taverner T Okoth K Wang J Chandan JS Sainsbury C Zemedikun DT Thomas GN Parekh D Marshall T Sapey E Adderley NJ Nirantharakumar K | 2021 | 中华高血压杂志2021，29，8： | 1 |
| 9 | Evaluation of false uh rasonographic diagnosis in cows by measuring plasma levels of bovine pegnancy-associated glycoprotein 显示文摘 | Szenci O Taverne M H Beckers J F | 1998 | Vet Rec1998，142，12： | 1 |
| 10 | Lingual orthodantics: a review of its history 显示文摘 | Poon KC Taverne AAR | 1997 | Aust Orthod J1997，76，2： | 1 |
| 11 | Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor显示文摘 | Goossens L Taverne T | 2002 | Bioorg Med Chem Lett2002，12，5： | 1 |
| 12 | 158-mJ Pulses From a Single-Transverse-Mode, Large-Mode-Area Erbium- Doped Fiber Amplifier显示文摘 | Taverner D Richardson D J Dong L | 1997 | Optics Letters1997，22，6： | 1 |
| 13 | Differences in mucus and serum immunoglobulin of carp显示文摘 | Rombout J Taverne N de Kamp M V | | 0，，04： | 1 |
| 14 | New COX-2/5-LOX inhibitors:apoptosis-inducing agents potentially useful in prostate cancer chemotherapy显示文摘 | Taverne T Telliez A | 2004 | J Med Chem2004，47，25： | 1 |
| 15 | Prediction of the digestible energy in pig diets from analyses of fibre contents显示文摘 | King R H M R Taverner | 1975 | Animal Prok1975，21，： | 1 |
| 16 | Identifying transcriptional targets显示文摘 | Taverner N V Smith J C Wardle F C | 2004 | Genome Biology2004，5，3： | 1 |
| 17 | Pharmacokinetic study of extradural and intrathecal sufentanil anaesthesia for major surgery显示文摘 | Ionescu TI Taverne RH Houweling PL | 1991 | Br J Anaesth1991，66，4： | 1 |
| 18 | External api- cal root resorption of posterior teeth in asthmatics after orthodontic treatment显示文摘 | McNab S Battistutta D Taverne A | 1999 | Am J Orthod Dentofacial Orthop1999，116，5： | 1 |
| 19 | Massive bleeding from the ileum:a late complication of pelvic radiotherapy显示文摘 | Taverner D Talbot IC Carr-Locke DL | | American Journal of Gastroenterology0，，： | 1 |
| 20 | Externai Apical Root Resorption Following Orthodontic Treatment显示文摘 | MCNAB S BATTISTUTTA D TAVERNE A | 2000 | Angle Orthod2000，70，3： | 1 |
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