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| 1 | Investigation of factors affecting on viscosity reduction of sludge from Iranian crude oil storage tanks显示文摘Crude oil is a kind of water/oil emulsion, which the oil phase consists of organic molecules with different molecular weights such as alkanes, paraffin, asphaltene, and resins. Due to the change in physicochemical conditions during the production, transportation, storage, and refining, heavier molecules can precipitate from crude oil. Thus, viscous sludge formed at the bottom of storage tanks can cause many problems including reduction of storage capacity of tank, oil contamination, corrosion, repair costs, environmental pollution, etc. The reduction of sludge viscosity can be achieved by reduction of its interfacial tension. In this study, different chemical and physical factors, influencing prepared emulsions(made of sludge, water and surfactant), such as surfactants, solvents, temperature, pressure, and mixing conditions were investigated. Results showed that non-ionic surfactants(like bitumen emulsifier), and solvents(such as mixed xylene, AW-400, and AW-402), injection of additives, applying pressure, and mixing operations had a positive effect on reduction of emulsion viscosity. All experiments were carried out with sludge obtained from crude oil storage tanks at Kharg Island,Iran. | Masoumeh Hassanzadeh Leila Tayebi Hedieh Dezfouli | 2018 | Petroleum Science2018，15，3： | 11 |
| 2 | Pivotal role of long non-coding ribonucleic acid-X-inactive specific transcript in regulating immune checkpoint programmed death ligand 1 through a shared pathway between miR-194-5p and miR-155-5p in hepatocellular carcinoma显示文摘BACKGROUND Anti-programmed death therapy has thrust immunotherapy into the spotlight.However,such therapy has a modest response in hepatocellular carcinoma(HCC).Epigenetic immunomodulation is a suggestive combinatorial therapy with immune checkpoint blockade.Non-coding ribonucleic acid(ncRNA)driven regulation is a major mechanism of epigenetic modulation.Given the wide range of ncRNAs that co-opt in programmed cell-death protein 1(PD-1)/programmed death ligand 1(PD-L1)regulation,and based on the literature,we hypothesized that miR-155-5p,miR-194-5p and long non-coding RNAs(lncRNAs)X-inactive specific transcript(XIST)and MALAT-1 are involved in a regulatory upstream pathway for PD-1/PD-L1.Recently,nutraceutical therapeutics in cancers have received increasing attention.Thus,it is interesting to study the impact of oleuropein on the respective study key players.AIM To explore potential upstream regulatory ncRNAs for the immune checkpoint PD-1/PD-L1.METHODS Bioinformatics tools including microrna.org and lnCeDB software were adopted to detect targeting of miR-155-5p,miR-194-5p and lncRNAs XIST and MALAT-1 to PD-L1 mRNA,respectively.In addition,Diana tool was used to predict targeting of both aforementioned miRNAs to lncRNAs XIST and MALAT-1.HCC and normal tissue samples were collected for scanning of PD-L1,XIST and MALAT-1 expression.To study the interaction among miR-155-5p,miR-194-5p,lncRNAs XIST and MALAT-1,as well as PD-L1 mRNA,a series of transfections of the Huh-7 cell line was carried out.RESULTS Bioinformatics software predicted that miR-155-5p and miR-194-5p can target PDL1,MALAT-1 and XIST.MALAT-1 and XIST were predicted to target PD-L1 mRNA.PD-L1 and XIST were significantly upregulated in 23 HCC biopsies compared to healthy controls;however,MALAT-1 was barely detected.MiR-194 induced expression elevated the expression of PD-L1,XIST and MALAT-1.However,overexpression of miR-155-5p induced the upregulation of PD-L1 and XIST,while it had a negative impact on MALAT-1 expression.Knockdown of XIST did have an impact on PD-L1 expression;however,following knockdown of the negative regulator of X-inactive specific transcript(TSIX),PD-L1 expression was elevated,and abolished MALAT-1 activity.Upon co-transfection of miR-194-5p with siMALAT-1,PD-L1 expression was elevated.Co-transfection of miR-194-5p with siXIST did not have an impact on PD-L1 expression.Upon co-transfection of miR-194 with siTSIX,PD-L1 expression was upregulated.Interestingly,the same PD-L1 expression pattern was observed following miR-155-5p cotransfections.Oleuropein treatment of Huh-7 cells reduced the expression profile of PD-L1,XIST,and miR-155-5p,upregulated the expression of miR-194-5p and had no significant impact on the MALAT-1 expression profile.CONCLUSION This study reported a novel finding revealing that opposing acting miRNAs in HCC,have the same impact on PD-1/PD-L1 immune checkpoint by sharing a common signaling pathway. | Sara M Atwa Heba Handoussa Karim M Hosny Margarete Odenthal Hend M El Tayebi | 2020 | World Journal of Hepatology2020，12，12： | 9 |
| 3 | Behind the curtain of non-coding RNAs; long non-coding RNAs regulating hepatocarcinogenesis显示文摘Hepatocellular carcinoma(HCC) is one of the most common and aggressive cancers worldwide. HCC is the fifth common malignancy in the world and the second leading cause of cancer death in Asia. Long non-coding RNAs(lncRNAs) are RNAs with a length greater than 200 nucleotides that do not encode proteins. lncRNAs can regulate gene expression and protein synthesis in several ways by interacting with DNA, RNA and proteins in a sequence specific manner. They could regulate cellular and developmental processes through either gene inhibition or gene activation. Many studies have shown that dysregulation of lncRNAs is related to many human diseases such as cardiovascular diseases, genetic disorders, neurological diseases, immune mediated disorders and cancers. However, the study of lncRNAs is challenging as they are poorly conserved between species, their expression levels aren't as high as that of m RNAs and have great interpatient variations. The study of lncRNAs expression in cancers have been a breakthrough as it unveils potential biomarkers and drug targets for cancer therapy and helps understand the mechanism of pathogenesis. This review discusses many long non-coding RNAs and their contribution in HCC, their role in development, metastasis, and prognosis of HCC and how to regulate and target these lncRNAs as a therapeutic tool in HCC treatment in the future. | Aya El Khodiry Menna Afify Hend M El Tayebi | 2018 | World Journal of Gastroenterology2018，24，5： | 9 |
| 4 | Interplay between micro RNA-17-5p, insulin-like growth factor-Ⅱ through binding protein-3 in hepatocellular carcinoma显示文摘AIM: To investigate the effect of microR NA on insulinlike growth factor binding protein-3(IGFBP-3) and hence on insulin-like growth factor-Ⅱ(IGF-Ⅱ) bioavailability in hepatocellular carcinoma(HCC).METHODS: Bioinformatic analysis was performed using microrna.org, DIANA lab and Segal lab softwares. Total RNA was extracted from 23 HCC and 10 healthy liver tissues using mir Vana mi RNA Isolation Kit. microR NA-17-5p(miR-17-5p) expression was mimicked and antagonized in Hu H-7 cell lines using Hi Per Fect Transfection Reagent, then total RNA was extracted using Biozol reagent then reverse transcribed into cD NA followed by quantification of mi R-17-5p and IGFBP-3 expression using Taq Man real-time quantitative PCR. Luciferase reporter assay was performed to validate the binding of miR-17-5p to the 3'UTR of IGFBP-3. Free IGF-Ⅱ protein was measured in transfected Hu H-7 cells using IGF-Ⅱ ELISA kit. RESULTS: Bioinformatic analysis revealed IGFBP-3 as a potential target for miR-17-5p. Screening of miR-17-5p and IGFBP-3 revealed a moderate negative correlation in HCC patients, where mi R-17-5p was extensively underexpressed in HCC tissues(P = 0.0012), while IGFBP-3 showed significant upregulation in the same set of patients(P = 0.0041) compared to healthy donors. Forcing mi R-17-5p expression in Hu H-7 cell lines showed a significant downregulation of IGFBP-3 mR NA expression(P = 0.0267) and a significant increase in free IGF-Ⅱ protein(P = 0.0339) compared to mock untransfected cells using unpaired t-test. Luciferase assay validated IGFBP-3 as a direct target of mi R-17-5p; luciferase activity was inhibited by 27.5% in cells co-transfected with miR-17-5p mimics and the construct harboring the wild-type binding region 2 of IGFBP-3 compared to cells transfected with this construct alone(P = 0.0474).CONCLUSION: These data suggest that regulating IGF-Ⅱ bioavailability and hence HCC progression can be achieved through targeting IGFBP-3 via manipulating the expression of miR NAs. | Danira Ashraf Habashy Hend Mohamed El Tayebi Injie Omar Fawzy Karim Adel Hosny Gamal Esmat Ahmed Ihab Abdelaziz | 2016 | World Journal of Hepatology2016，8，23： | 3 |
| 5 | Epigenetic regulation of insulin-like growth factor axis in hepatocellular carcinoma显示文摘The insulin-like growth factor(IGF) signaling path-way is an important pathway in the process of hepa-tocarcinogenesis,and the IGF network is clearly dysregulated in many cancers and developmental abnormalities.In hepatocellular carcinoma(HCC),only a minority of patients are eligible for curative treatments,such as tumor resection or liver transplant.Unfortunately,there is a high recurrence of HCC after surgical tumor removal.Recent research efforts have focused on targeting IGF axis members in an attempt to find therapeutic options for many health problems.In this review,we shed lights on the regulation of members of the IGF axis,mainly by micro RNAs in HCC.Micro RNAs in HCC attempt to halt the aberrant expression of the IGF network,and a single micro RNA can have multiple downstream targets in one or more signaling pathways.Targeting micro RNAs is a relatively new approach for identifying an efficient radical cure for HCC. | Hend Mohamed El Tayebi Ahmed Ihab Abdelaziz | 2016 | World Journal of Gastroenterology2016，22，9： | 3 |
| 6 | Fabrication of an electrochemical sensor for determination of doxorubicin in human plasma and its interaction with DNA显示文摘In this work, an electrochemical sensor was fabricated for determination of an anthracycline, doxorubicin(DOX) as a chemotherapy drug in plasma based on multi-walled carbon nanotubes modified platinum electrode(Pt/MWCNTs). DOX was effectively accumulated on the surface of modified electrode and generated a pair of redox peaks at around 0.522 and 0.647 V(vs. Ag/Ag Cl) in Britton Robinson(B-R) buffer(p H 4.0, 0.1 M). The electrochemical parameters including p H, type of buffer, accumulation time, amount of modifier and scan rate were optimized. Under the optimized conditions, there was a linear correlation between cathodic peak current and concentration of DOX in the range of 0.05–4.0 μg/m L with the detection limit of 0.002 μg/m L. The number of electron transfers(n) and electron transfer-coefficient(α) were estimated as 2.0 and 0.25, respectively. The constructed sensor displayed excellent precision, sensitivity, repeatability and selectivity in the determination of DOX in plasma. Moreover, cyclic voltammetry studies of DOX in the presence of DNA showed an intercalation mechanism with binding constant(K_b) of 1.12×10~5L/mol. | Reza Hajian Zahra Tayebi Nafiseh Shams | 2017 | Journal of Pharmaceutical Analysis2017，7，1： | 2 |
| 7 | 睑缘炎的临床研究(英文)显示文摘目的:讨论睑缘炎的临床表现、分型、诊断、发病机制、并发症以及治疗。方法:本研究包括在眼科门诊通过裂隙灯检查确诊为睑缘炎的患者300例,针对每位患者完成一份调查问卷,在了解患者患病原因的基础上给予治疗。通过随访评价患者的治疗效果和并发症。结果:本研究中,脂溢性睑缘炎多表现为鳞屑样病变(62.5%),但感染型或混合型睑缘炎多表现为溃疡样病变(P<0.001)。此外,脂溢性睑缘炎的病程多为慢性,而感染型病程多为急性(P<0.001)。由不同类型睑缘炎而引起麦粒肿、霰粒肿、上皮型角膜炎、结膜炎及干眼症等并发症的几率不同(P<0.05)。其中,干眼症和上皮型角膜炎的临床病程多为慢性病程(P<0.05)。一些潜在的全身疾病如脂溢性皮炎、特异性皮炎、糖尿病、过敏、红斑痤疮等与睑缘炎的发生之间有密切的关系。结论:睑缘炎是眼科的常见疾病,需要注意预防该病的并发症。 | Mohammad Reza Besharati Abolghaseme Rastegar Naeimeh Tayebi | 2007 | 国际眼科杂志2007，7，5： | 2 |
| 8 | Expression of insulin-like growth factor-II, matrix metalloproteinases, and their tissue inhibitors as predictive markers in the peripheral blood of HCC patients显示文摘 | H.M. El Tayebi W. Salah I.H. El Sayed A.R.N. Zekri N. Zayed E.S. Salem G. Esmat A.I. Abdelaziz | 2011 | Biomarkers2011，，4： | 2 |
| 9 | miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma显示文摘 | H.M. El Tayebi K.A. Hosny G. Esmat K. Breuhahn Ahmed Ihab Abdelaziz | 2012 | FEBS Letters2012，，19： | 2 |
| 10 | Repression of miR-17-5p with elevated expression of E2F-1 and c-MYC in non-metastatic hepatocellular carcinoma and enhancement of cell growth upon reversing this expression pattern显示文摘 | H.M. El Tayebi K. Omar S. Hegy M. El Maghrabi M. El Brolosy K.A. Hosny G. Esmat A.I. Abdelaziz | 2013 | Biochemical and Biophysical Research Communications2013，，3： | 2 |
| 11 | A pleiotropic effect of the single clustered hepatic metastamiRs miR-96-5pand miR-182-5p on insulin-like growth factor II, insulin-like growth factor-1receptor and insulin-like growth factor-binding protein-3 in hepatocellular carcinoma显示文摘 | Reem Assal Hend El Tayebi Karim Hosny Gamal Esmat Ahmed Abdelaziz | 2015 | Molecular Medicine Reports2015，，1： | 2 |
| 12 | Myoclonic epilepsy in Gancher disease: genotype-phenotype insights from a rare patient subgroup显示文摘 | Park JK Orvisky E Tayebi N | 2003 | Pediatr Res2003，53，3： | 1 |
| 13 | Metal-only Fresnel zone plate antenna for millimeter-wave frequency bands显示文摘 | GOMEZ J TAYEBI A LUCAS J D | 2014 | IET Microwave Antennas Propagation2014，8，6： | 1 |
| 14 | Enhancement of fracture toughness in bioactive glass-based nanocomposites with nanocrystalline forsterite as advanced biomaterials for bone tissue engineering applications显示文摘 | Abolfazl Yazdanpanah Reza Kamalian Fathollah Moztarzadeh Masoud Mozafari Roya Ravarian Lobat Tayebi | 2012 | Ceramics International2012，，6： | 1 |
| 15 | Attitude stabilization of a VTOL quadrotor aircraft 显示文摘 | Tayebi Abdelhamid McGilvray Stephen | 2006 | IEEE Transactions on Control Systems Technology2006，14，3： | 1 |
| 16 | Attitude stabilization of a four-rotor aerial robot 显示文摘 | Tayebi A McGilvray S | 2005 | 43rd Conference on Decision and Control2005，，12： | 1 |
| 17 | Foliations on the tangent bundle of Finsler manifolds显示文摘Let M be a smooth manifold with Finsler metric F,and let T M be the slit tangent bundle of M with a generalized Riemannian metric G,which is induced by F.In this paper,we prove that (i) (M,F) is a Landsberg manifold if and only if the vertical foliation F V is totally geodesic in (T M,G);(ii) letting a:= a(τ) be a positive function of τ=F 2 and k,c be two positive numbers such that c=2 k(1+a),then (M,F) is of constant curvature k if and only if the restriction of G on the c-indicatrix bundle IM (c) is bundle-like for the horizontal Liouville foliation on IM (c),if and only if the horizontal Liouville vector field is a Killing vector field on (IM (c),G),if and only if the curvature-angular form Λ of (M,F) satisfies Λ=1-a 2/R on IM (c). | PEYGHAN Esmaei TAYEBI Akbar ZHONG ChunPing | 2012 | Science China Mathematics2012，55，3： | 1 |
| 18 | On the virtual crack extension method for calculation of the rates of energy release rates显示文摘 | Hwand C G Wawrzynek P A Tayebi A K | 1998 | Engineering Fracture Mechanics1998，59，4： | 1 |
| 19 | Effects of aluminosilicate minerals on copper-molybdenum flotation from Sarcheshmeh porphyry ores显示文摘 | JORJANI E BARKHORDARI H R TAYEBI KHORAMI M FAZELI A | 2011 | Minerals Engineering2011，24，8： | 1 |
| 20 | Phospholipase A2 inhibitors protect against prion and Abeta mediated synapse degeneration显示文摘 | Bate C Tayebi M Williams A | | 0，，： | 1 |
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