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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Evaluation and outcome of young children with chroine cought显示文摘 | Marchant JM Masters LB Taylor SM etal | 2006 | Chest2006，129，5： | 1 |
| 3 | Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task显示文摘 | Astur RS Taylor LB Mamelak AN | 2002 | Behav Brain Res2002，132，1： | 1 |
| 4 | The registry of the International Society for Heart and Lung Transplantation:twentieth official adult heart transplant report-2003显示文摘 | Taylor DO Edwards LB Mohacsi PI | 2003 | J Heart Lung Transplant2003，22，6： | 1 |
| 5 | The reg-istry of the International society for heart and lung transplantatlon:twenty-first official adult lung and heart-lung transplant report-2004显示文摘 | Trulock EP Edwards LB Taylor DO | 2004 | J Heart Lung Transplantation2004，23，： | 1 |
| 6 | Harnessing the imagination: Mental simulation, self-regulation and coping显示文摘 | Pham LB Rivkin ID at al | 1998 | American Psychologist1998，53，： | 1 |
| 7 | Registry of the International Society for Heart and Lung Transplantation: twenty-second official adult heart transplant report -2005显示文摘 | Taylor DO Edwards LB Boucek MM | 2005 | J Heart Lung Transplant2005，24，8： | 1 |
| 8 | Registry of the International Society for Heart and Lung Transplantation:twenty-fourth official adult heart transplant report-2007显示文摘 | Taylor DO Edwards LB Boucek MM | 2007 | J Heart Lung Transplant2007，26，8： | 1 |
| 9 | PAS domains: internal sensors of oxygen, redox potential, and light显示文摘 | Taylor BL Zhulin lB | 1999 | Microbiol Mol Biol Rev1999，63，2： | 1 |
| 10 | The Registry of the International Society for Heart and Lung Transplantation: twentyfirst official adult heart transplant report-2004 显示文摘 | Taylor DO Edwards LB Boucek MM | 2004 | J Heart Lung Transplant2004，23，7： | 1 |
| 11 | The Registry of the International Society for Heart and Lung Transplantation:twenty-first official adult heart transplant report–2004显示文摘 | Taylor DO Edwards LB Boucek MM | 2004 | J Heart Lung Transplant2004，23，： | 1 |
| 12 | Evolutionarily stable strategy and game dynamics显示文摘 | Taylor PD Jonker LB | 1978 | Mathematical Biosciences1978，40，12： | 1 |
| 13 | Registry of the International Society for Heart and Lung Transplantation: twentythird official adult heart transplantation report-2006 显示文摘 | Taylor DO Edwards LB Boucek MM | 2006 | J Heart Lung Transplant2006，25，8： | 1 |
| 14 | Lung cancer screening: the Mayo program 显示文摘 | Fontana RS Sanderson DR Woolner LB Taylor WF Miller WE Muhm JR | 1986 | J Occup Med1986，28，28： | 1 |
| 15 | Humans with hip- pocampus damage display severe spatial memory im-pairments in a virtual Morris water task 显示文摘 | Astur RS Taylor LB Mamelak AN | 2002 | Behav Brain Res2002，132，1： | 1 |
| 16 | Registry of the International Society for Heart and Lung Transplantation: twenty fifth official adult heart transplant report-2008显示文摘 | Taylor DO Edwards LB Aurora P | 2008 | J Heart Lung Transplant2008，27，9： | 1 |
| 17 | Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task显示文摘 | Astur RS Taylor LB Mamelak AN | 2002 | Behav Brain Res2002，132，1： | 1 |
| 18 | The registry of the international society for heart and lung transplantation:twenty-first official lung and heart-lung transplant report显示文摘 | Trulock EP Edwards LB Taylor DO | 2004 | J Heart Lung Transplant2004，23，7： | 1 |
| 19 | Registry of the international society for heart and lung transplantation: twenty-third official adult lung and heart-lung transplantation report 显示文摘 | Trulock EP Edwards LB Taylor DO | 2006 | J Heart Lung Transplant2006，25，8： | 1 |
| 20 | Registry of the International Society for Heart and Lung Transplantation:Twentysecond Official Adult Lung and Heart-Lung Transplant Report2005显示文摘 | Trnlock EP Edwards LB Taylor DO | 2005 | J Heart Lung Transplant2005，24，： | 1 |
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