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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Pharmacological evaluation of several major ingredients of Chinese herbal medicines in human hepatoma Hep3B cells 显示文摘 | Chou C C Pan S L Teng C M | 2003 | Eur J Pharm Sci2003，19，5： | 2 |
| 3 | Preparation of activated carbon from bituminous coal with phosphoric acid activation显示文摘 | Teng H Yeh T S Hsu L Y | 1999 | Carbon1999，36，： | 1 |
| 4 | Transferring R&D knowledge: the key factors affecting knowledge transfer success 显示文摘 | Cummings J L Teng B S | 2003 | Journal of Engineering and Technology Management2003，20，2： | 1 |
| 5 | Transferring R&D knowledge:the key factors affecting knowledge transfer success显示文摘 | CUMMINGS J L TENG B S | | 0，，02： | 1 |
| 6 | Transferring R&D knowledge: the key factors affecting knowledge transfer success 显示文摘 | CUMMINGS J L TENG B S | 2003 | Jour- nal of Engineering and Technology Management2003，20，12： | 1 |
| 7 | Peritoneal microvascu-lar endothelial function and the microinflammatorystate are associated with baseline peritoneal trans-port characteristics in uremic patients显示文摘 | Teng L Chang M Liu S | 2015 | Int UrolNephrol2015，47，： | 1 |
| 8 | Transferring R&D knowledge:The key factors affecting knowledge transfer success显示文摘 | CUMMINGS J L TENG B S | 2003 | Journal of Engineering and Technology Management2003，20，： | 1 |
| 9 | Transferring R&D knowledge: The key factors affecting knowledge transfer success 显示文摘 | Cummings J L Teng B S | 2003 | Journal of Engineering &Technology Management2003，20，12： | 1 |
| 10 | Tectonic evolution of late Cenozoic arc continent collision in Taiwan 显示文摘 | Teng L S | 1990 | American Association of Petroleum Bulletin1990，74，6： | 1 |
| 11 | An Inventory Model for Increasing Demand under Two Levels of Trade Credit Linked to Order Quantity显示文摘 | Teng J T Yang G L Chern M S | 2013 | Applied Mathematical Modelling2013，，37： | 1 |
| 12 | Developing Energy Conservation and Carbon Reduction Indicators for the Hotel Industry in Tai- wan 显示文摘 | TENG C C HORNG J S HUM L | 2011 | International Journal of Hospitality Management2011，31，1： | 1 |
| 13 | Partial backlogging inventory lot-size models for deteriorating items with fluctuating demand under inflation 显示文摘 | Chern M S Yang H L Teng J T Papachristos S | 2008 | European Journal of Operational Research2008，191，1： | 1 |
| 14 | The PCSK9 gene E670G polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan显示文摘 | HSU L A TENG M S KO Y L | 2009 | Clin Chem Lab Med2009，47，2： | 1 |
| 15 | Degenerative disorders of the lumbar and cervical spine显示文摘 | ROH J S TENG A L YOO J U | 2005 | Orthop Clin North Am2005，36，3： | 1 |
| 16 | Transferring R&D knowledge: The key factors aftecting knowledge transfer success 显示文摘 | Cummings J L Teng B S | 2003 | Journal of Engineering and Technology Management2003，20，12： | 1 |
| 17 | An Economic Order Quantity Model for Deteriorating Items with Partially Permissible Delay in Payments Linked to Order Quantity显示文摘 | Ouyang L Y Teng J T Goyal S K Yang C T | 2009 | European Journal of Operational Research2009，194，2： | 1 |
| 18 | QTL analysis of rice low temperature germinability显示文摘 | Teng S Zeng D L Qian Q Yasufumi K Huang D L Zhu L H | 2001 | Chinese Sci Bull2001，46，21： | 1 |
| 19 | New C2-symmetric 2,2′-bipyridine crown macrocycles for enantioselective recognition of amino acid derivatives显示文摘 | LEE C S TENG P F WONG W L | 2005 | Tetrahedron2005，61，： | 1 |
| 20 | Improvement of alum andPAC1 coagulation by plolyacrylamides for the treatment of pulp and papermill wastewater显示文摘 | AHM AD A L WONG S S TENG T T | 2007 | Chemical Engineering Joumal2007，5279，8： | 1 |
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