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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Human mitogen-activated protein kinase 4 as a candidate tumor suppressor显示文摘 | Teng DH Perry WL Hogan JK | 1997 | Cancer Res1997，57，： | 1 |
| 3 | Enhancement of learning behaviour by a potent nitric oxide-guanylate cyclase activator YC-1显示文摘 | Chien WL Liang KC Teng CM | 2005 | Eur J Neurosci2005，21，6： | 1 |
| 4 | Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole 显示文摘 | Chien WL Liang KC Teng CM | 2003 | Sol Phannacol2003，63，6： | 1 |
| 5 | Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator,3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole显示文摘 | Chien WL Liang KC Teng CM | 2003 | Mol Pharmacol2003，63，6： | 1 |
| 6 | Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor 显示文摘 | Teng DH Perry lii WL Hogan JK | 1997 | Cancer Res1997，57，19： | 1 |
| 7 | Enhancement of learning behaviour by a potent nitric oxide-guanylate cyclase activator YC-1显示文摘 | Chien WL Liang KC Teng CM | 2005 | Eur J Neurosci2005，21，6： | 1 |
| 8 | Regneration of Anthurium adventitious shoots using liquid or raftculture 显示文摘 | Teng WL | 1997 | Plantcell Tissue and Organ Culture1997，，49： | 1 |
| 9 | Functional identification of conjugation and replication regions of the tetracycline resistance plasmid pCW3 from Clostridium perfringens显示文摘 | Bannam TL Teng WL Bulach D | | 0，，13： | 1 |
| 10 | Inappropriately elevated endothelin-1 plays a role in the pathogenesis of intradialytic hypertension显示文摘 | Teng J Tian J Lv WL | 2014 | Hemodial Int2014，24，8： | 1 |
| 11 | Sorafenib for hepatocellular carcinoma patients beyond Milan criteria after orthotopic liver transplantation: a case control study 显示文摘 | Teng CL Hwang WL Chen YJ | 2012 | World J Surg Oneol2012，10，： | 1 |
| 12 | Human mitogen- activated protein kinase kinase 4 as a candidate tumor suppressor 显示文摘 | TENG DH PERRY WL HOGAN JK | 1997 | Cancer Res1997，57，19： | 1 |
| 13 | CD4^+ CD25^+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer 显示文摘 | Mark JS Michele WL Teng JS | 2006 | J lmmunol2006，176，3： | 1 |
| 14 | Bone cement-induced pulmonary embolism in a myeloma patient显示文摘 | Chou CW Teng CL Hwang WL | | 0，，04： | 1 |
| 15 | Enhancement of learning behaviour by a potent nitric oxide-guanylate cyclase activator YC- 1 显示文摘 | Chien WL Liang KC Teng CM | 2005 | Eur J Neurosci2005，21，6： | 1 |
| 16 | Synthesis of a new p Hsensitive folate-doxorubicin conjugate and its antitumor activity in vitro显示文摘 | YE WL TENG ZH LIU DZ | 2013 | J Pharm Sci2013，102，2： | 1 |
| 17 | Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor显示文摘 | Teng DH Perry WL 3rd Hogan JK | 1997 | Cancer Res1997，57，： | 1 |
| 18 | Enhancement of learning behaviourby a potent nitric oxide-guanylate cyclase activator YC-1 显示文摘 | Chien WL Liang KC Teng CM | 2005 | Eur J Neu-rosei2005，21，6： | 1 |
| 19 | Regneration of Anthurium adventitious shoots using liquid or raft culture 显示文摘 | Teng WL | 1997 | Plant cell Tissue and Organ Culture1997，49，： | 1 |
| 20 | Inappropriately elevated endothelin-1 plays a role in the pathogenesis of intradialytic hypertension显示文摘 | Teng J Tian J Lv WL | 2014 | Hemodial Int2014，24，8： | 1 |
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