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1篇 您的检索式:作者名="Tengfang Long"
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1Cysteine-Specific Bioconjugation and Stapling of Unprotected Peptides by Chlorooximes显示文摘Cyclic peptides have found applications in fields ranging from drug discovery to nanomaterials.Peptide stapling reagents crosslink two or more residues in peptides to generate macrocycles of diverse topology and introduce linker units that might directly impact the properties and biological functions of cyclic peptides.Herein,we demonstrate that chlorooxime derivatives are cysteine-specific peptide bioconjugation and stapling reagents that generate stable thiohydroximate linkages.Qingqing Chen Tengfang Long Jie Zheng Wangjian Sheng Shuaishuai Sun Wei Wei Jing Zhao Huan Wang 2022CCS Chemistry2022,4,10:0
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