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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Effects of flow cytometry analysis on morphology and viability of fragile phytoplankton显示文摘 | ELIN M H TERRY L C CLARICE M Y | 1987 | Applied and Environmental Microbiology1987，53，11： | 1 |
| 3 | Grant: Earnings Management and the Abuse of Materiality 显示文摘 | C · Terry Grant Chauncey M Depree JR and Gerry H | 2000 | September2000，，： | 1 |
| 4 | The Occurance of DBPs in Utah Drinking Waters 显示文摘 | NIEMINSKI SANWAT C H TERRY L | 1993 | J WWWA1993，85，9： | 1 |
| 5 | Sensors and Actuators显示文摘 | Allen H V Terry S C De Bruin D W | 1989 | 20:153-1611989，20，： | 1 |
| 6 | A gas chromatographic air analyzer fabricated on a silicon wafer显示文摘 | Terry S C Jerman J H Angell J B | 1979 | Electron Devices IEEE Transactions on1979，26，12： | 1 |
| 7 | Near 1 kW of continuous-wave power from a single high-efficiency diode-laser bar 显示文摘 | LI H X TERRY T IRVING C | 2007 | IEEE Photonics Technology Letters2007，19，13： | 1 |
| 8 | A gas chromatographic air analyzer on a sillicon wafer显示文摘 | Jerman J H Angell J B | 1979 | IEEE Trans Electron Devices1979，26，： | 1 |
| 9 | Agricultural insur- ance as an environmental policy tool 显示文摘 | KEITH C TERRY H COREY M | 2003 | Journal of Agricul- tural and Applied Economics2003，35，2： | 1 |
| 10 | Smoking Status, Reading Level, and Knowledge of Tobacco Effects among Low-Income Pregnant Women显示文摘 | Connie L Arnold Terry C Davis Hans J Berkel Robert H Jackson Indrani Nandy Steve London | 2001 | Preventive Medicine2001，，4： | 1 |
| 11 | High-density data storage using proximal probe techniques 显示文摘 | H J Mamin B D Terris L S Fan S Hoen R C Barrett and D Rugar | 1995 | IBM J Res Develop1995，，： | 1 |
| 12 | Expression of constitutively active Nuclear-κB RelA transcription factor in blasts of acute myeloid leukemia显示文摘 | Carlos E Bueso-Ramos Frederico C Rocha Shishir Shishodia L.Jeffrey Medeiros Hagop M Kantarjian Saroj Vadhan-Raj Zeev Estrov Terry L Smith Martin H Nguyen Bharat B Aggarwal | 2004 | Human Pathology2004，，2： | 1 |
| 13 | Early and late results ofdescendingthoracic and thoracoabdominal aortic aneurysm open repairwith deep hypothermia and circulatory arrest 显示文摘 | Fehrenbacher JW Siderys H Terry C | 2010 | J Thorac CardiovascSurg2010，140，6： | 1 |
| 14 | In vitro fermentation properties of selected fructooligosaccharide-containing vegetables and in vivo colonic microbial populations are affected by the diets of healthy human infants显示文摘 | ELIZABETH A F TERRY F H RACHELL C W | 2002 | Human Nutrition and Metabolism2002，132，8： | 1 |
| 15 | Effects of chronic epilepsy on heart rate variability A case-control study显示文摘BACKGROUND: Dysfunctional autonomic cardiac regulation is thought to be associated with high mortality in epileptic patients.OBJECTIVE: To explore changes in sympathetic and parasympathetic activities in epileptic patients with repetitive generalized tonic-clonic seizures by observing interictal heart rate.DESIGN,TIME AND SETTING: A case-control study was performed at the Buddhist Tzu Chi General Hospital from July 2006 to May 2009.PARTICIPANTS: A total of 30 patients,comprising 15 males and 15 females,who presented with chronic epilepsy and repetitive generalized tonic-clonic seizures according to International League Against Epilepsy guidelines (ILAE,1989),were selected.In addition,30 matched,healthy volunteers were selected as controls.METHODS: Lead I electrocardiogram was performed in the epilepsy and control groups for 5 minutes during a daytime interictal period.Frequency-domain analysis of heart rate variability was performed using fast Fourier transformation.MAIN OUTCOME MEASURES: Heart rate interval,high frequency (HF;0.15–0.45 Hz) power,low frequency (LF;0.04–0.15 Hz) power,and LF/(HF + LF) expressed in normalized units (LF%).RESULTS: Compared with the control group,the epilepsy group exhibited a significantly lower mean heart rate interval and HF power,but a significantly greater LF% (P < 0.01).There was no significant difference in LF power between the groups (P = 0.17).CONCLUSION: Patients with chronic epilepsy exhibited faster heart rates during interictal periods,which could contribute to higher sympathetic and lower parasympathetic activities. | Yueloong Hsin Cheryl C H Yang Terry B J Kuo Tomor Harnod | 2010 | Neural Regeneration Research2010，5，2： | 1 |
| 16 | Management of women who test positive for high-risk types of human papillomavirus: the HART study显示文摘 | J Cuzick A Szarewski H Cubie G Hulman H Kitchener D Luesley E McGoogan U Menon G Terry R Edwards C Brooks M Desai C Gie L Ho I Jacobs C Pickles P Sasieni | 2003 | The Lancet2003，，9399： | 1 |
| 17 | Biomedical Implications of a Thrombus-Specific US Contrast Agent显示文摘 | Evan C Unger Terry O Matsunaga Thomas P McCreery Robert H Sweitzer | 2002 | Academic Radiology2002，，1： | 1 |
| 18 | Accelerometer sy-stems with selftestable features显示文摘 | Allen H V Terry S C De Bruin D W | 1989 | Sensors and Actuators1989，20，12： | 1 |
| 19 | The Chlamydomonas genome reveals the evolution of key animal and plant functions 显示文摘 | Merchant S S Prochnik S E Vallon O Harris E H Karpowicz S J Witman G B Terry A Salamov A Fritz-Laylin L K Marechal- Drouard L Marshall W F Qu L H Nelson D R Sanderfoot A A Spalding M H Kapitonov V V Ren Q Ferris P Lindquist E Shapiro H Lucas S M Grimwood J Schmutz J Cardol P Cerutti H Chanfreau G Chen C L Cognat V Croft M T Dent R Dutcher S Fernandez E Fukuzawa H Gonzalez-Ballester D Gonzalez-Halphen D Hallmann A Hanikenne M Hippler M Inwood W Jabbari K Kalanon M Kuras R Lefebvre P A Lemaire S D Lobanov A V Lohr M Manuell A Meier I Mets L Mittag M Mittelmeier T Moroney J V Moseley J Napoli C Nedelcu A M Niyogi K Novoselov S V Paulsen I T Pazour G Purton S Ral J P Riano-Pachon D M Riekhof W Rymarquis L Schroda M Stern D Umen J Willows R Wilson N Zimmer S LAllmer J Balk J Bisova K Chen C J Elias M Gendler K Hauser C Lamb M R Ledford H Long J C Minagawa J Page M D Pan J Pootakham W Roje S Rose A Stahlberg E Terauchi A M Yang P Ball S Bowler C Dieckmann C L GIadyshev V N Green P Jorgensen R Mayfield S Mueller-Roeber B Rajamani S Sayre R T Brokstein P Dubchak I Goodstein D Hornick L Huang Y W Jhaveri J Luo Y Martinez D Ngau W C Otillar B Poliakov A Porter A Szajkowski L Werner G Zhou K Grigoriev I V Rokhsar D S Grossman A R | 2007 | Science2007，318，5848： | 1 |
| 20 | Early and late results of descending thoracic and thoracoabdominal aortic aneurysm open repair with deep hypothermia and circulatory arrest 显示文摘 | Fehrenbacher JW Siderys H Terry C | 2010 | J Thorac Cardiovasc Surg2010，140，： | 1 |
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