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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Pore-Scale Investigation of Biomass Plug Development and Propagation in Porous Media显示文摘 | TERRI L STEWART FOGLER H SCOTT | 2002 | Biotechnology and Bioengineering2002，77，5： | 2 |
| 4 | 膜型巨噬细胞集落刺激因子对人脑胶质细胞瘤的免疫治疗作用显示文摘摘要 目的 探讨基因转染膜型巨噬细胞集落刺激因子(mM-CSF)对U251MG人脑胶质瘤细胞的免疫治疗作用。方法 用逆转录病毒载体将mM-CSF基因转入U251MG细胞,采用流式细胞术检测mM-CSF的表达;通过细胞毒性实验、兔疫组化方法以及观察转染细胞在免疫缺陷小鼠体内的生长情况研究mM-CSF对U251MG细胞的作用。结果①获得了表达mM-CSF的MG-2F11细胞;②大鼠巨噬细胞、人外周血淋巴细胞(PBL)和人单核细胞均可杀伤MG-2F11细胞,但不能杀伤U251MG母细胞;③接种瘤细胞到裸小鼠皮下18 h后,侵入MG-2F11肿瘤的巨噬细胞明显多于侵入MG-VV(仅转染病毒载体的U251MG细胞)肿瘤的巨噬细胞;④接种MG-2F11细胞的8只裸小鼠均无肿瘤生长,而接种MG-VV细胞的8只裸小鼠中的7只有肿瘤生长(P<0.01);另一免疫缺陷更严重的NIH-bg-nu-xidBR 小鼠,接种MG-2F11细胞后8只中的1只有肿瘤生长,而接种MG-VV细胞后8只中的7只有肿瘤生长(P<0.01)。结论mM-CSF转染的人脑胶质瘤细胞致瘤性降低,有进一步对其进行临床研究的必要。 | 陈义军 Cheri Lloyd Ramon Sanchez Martin R Jadus H Terry Wepsic | 2002 | 中华神经外科疾病研究杂志2002，1，3： | 2 |
| 5 | Effects of flow cytometry analysis on morphology and viability of fragile phytoplankton显示文摘 | ELIN M H TERRY L C CLARICE M Y | 1987 | Applied and Environmental Microbiology1987，53，11： | 1 |
| 6 | Strategic cyclical scaling: bridging five orders of magnitude scale gaps in climatic and ecological studies显示文摘 | Root Terry L Schneider Stephen H | 2002 | Integrated Assessment2002，3，23： | 1 |
| 7 | Cadmium tolerance and accumulation in Indian mustard is enhanced by overexpressing- glutamylcysteine synthetase显示文摘 | ZHU Y PILON-SMITS E A H TERRY N | 1999 | Plant Physiol1999，121，4： | 1 |
| 8 | A meta-analysis of relations between person–organization fit and work attitudes显示文摘 | Michelle L Verquer Terry A Beehr Stephen H Wagner | 2002 | Journal of Vocational Behavior2002，，3： | 1 |
| 9 | Fruit and vegetable consumption in the prevention of esophageal and cardia cancers显示文摘 | Terry P Lagergren J Hansen H | 2001 | Eur J Cancer Prev2001，10，4： | 1 |
| 10 | The physcomitrella genome reveals evolutionary insights into the conquest of land by plants 显示文摘 | Rensing S A Lang D Zimmer A D Terry A Salamov A Shapiro H Nishiyama T Perroud P F Lindquist E A Kamisugi Y | 2008 | Science2008，319，5859： | 1 |
| 11 | Scrutinizing pharmaceuticals and personal care products in wastewater treatment 显示文摘 | Terries T A Joss A Siegrist H | 2004 | Environ Sci Technol2004，38，： | 1 |
| 12 | Effect of diet on partial efficiency of acetate use for body tissue synthesis by mature cattle显示文摘 | Terry H F Reynolds P J Moe P W | 1979 | AnimSei1979，48，： | 1 |
| 13 | The efficacy of spinosad againstthe western flower thrips, Frankliniella occidentalis, and its impact on associated biological control agents on greenhouse cucumbers in southern Ontario显示文摘 | Terri J Cynthia S D Ron H | 2005 | Pest Management Science2005，61，： | 1 |
| 14 | Fruit and vegetable consump- tion in the prevention of oesophageal and cardia cancers 显示文摘 | Terry P Lagergren J Hansen H | 2001 | Eur J Cancer Prey2001，10，4： | 1 |
| 15 | EBROS-Endless bar rolling system显示文摘 | Terry H Austen Ashlow MiIls | 2003 | Steel Technology2003，35，2： | 1 |
| 16 | Grant: Earnings Management and the Abuse of Materiality 显示文摘 | C · Terry Grant Chauncey M Depree JR and Gerry H | 2000 | September2000，，： | 1 |
| 17 | SWOT analysis: it is time for a product recall 显示文摘 | Terry H Roy W | 1997 | Long Range Planning1997，30，1： | 1 |
| 18 | 75 keV, 140 mA proton injector显示文摘 | JOSEPH D S TERRY L F LASH D H | 2002 | Review of Scientific Instruments2002，73，2： | 1 |
| 19 | A computerized method of visual acuity testing显示文摘 | Roy W Beck Pamela S Moke Andrew H Turpin Frederick L Ferris John Paul SanGiovanni Chris A Johnson Eileen E Birch Danielle L Chandler Terry A Cox R.Clifford Blair Raymond T Kraker | 2003 | American Journal of Ophthalmology2003，，2： | 1 |
| 20 | The Occurance of DBPs in Utah Drinking Waters 显示文摘 | NIEMINSKI SANWAT C H TERRY L | 1993 | J WWWA1993，85，9： | 1 |
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