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| 1 | Genetics of hepatocellular carcinoma显示文摘The completely assembled human genome has made it possible for modern medicine to step into an era rich in genetic information and high-throughput genomic analysis. These novel and readily available genetic resources and analytical tools may be the key to unravel the molecular basis of hepatocellular carcinoma (HCC). Moreover, since an efficient treatment for this disease is lacking, further understanding of the genetic background of HCC will be crucial in order to develop new therapies aimed at selected targets. We report on the current status and recent developments in HCC genetics. Special emphasis is given to the genetics and regulation of major signalling pathways involved in HCC such as p53, Wnt- signalling, TGFβ, Ras, and Rb pathways. Furthermore, we describe the influence of chromosomal aberrations as well as of DNA methylation. Finally, we report on the rapidly developing field of genomic expression profiling in HCC, mainly by microarray analysis. | Andreas Teufel Frank Staib Stephan Kanzler Arndt Weinmann Henning Schulze-Bergkamen Peter R Galle | 2007 | World Journal of Gastroenterology2007，13，16： | 21 |
| 2 | Update on autoimmune hepatitis显示文摘Autoimmune hepatitis (AIH) is a necroinflammatory liver disease of unknown etiology that occurs in children and adults of all ages. Characteristics are its autoimmune features,hyperglobulinemia (IgG),and the presence of circulating autoantibodies,as well as a response to immunosuppressant drugs. Current treatment consists of prednisone and azathioprine and in most patients this disease has become very treatable. Over the past 2 years,a couple of new insights into the genetic aspects,clinical course and treatment of AIH have been reported,which will be the focus of this review. In particular,we concentrate on genome-wide microsatellite analysis,a novel mouse model of AIH,the evaluation of a large AIH cohort for overlap syndromes,suggested novel criteria for the diagnosis of AIH,and the latest studies on treatment of AIH with budenoside and mycophenolate mofetil. | Andreas Teufel Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，9： | 17 |
| 3 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 4 | 髓外造血影像学表现显示文摘 | Teufel M Bares R Ernemann U Horger M Tbingen 曹毅媛 | 2009 | 放射学实践2009，24，2： | 5 |
| 5 | Hepatocellular carcinoma in patients with autoimmune hepatitis显示文摘AIM: To evaluate and confirm the low incidence of hepatocellular carcinoma (HCC) in patients with autoimmune hepatitis (AIH). At present only very few cases of HCC in patients with AIH and definite exclusion of chronic viral hepatitis have been published, suggesting that HCC due to AIH is rare. METHODS: In order to further investigate the incidence of HCC in patients with AIH, we reviewed our large cohort of 278 patients with AIH. RESULTS: Eighty-nine patients (32%) were diagnosed with liver cirrhosis, a preneoplastic condition for HCC. We studied a total of 431 patient years of cirrhosis in these patients, an average 4.8 years per patient. During this period none of the patients of our own study cohort developed HCC. However, three patients with HCC due to AIH associated liver cirrhosis were referred to our department for further treatment of HCC. In all three patients chronic viral hepatitis was excluded. CONCLUSION: We conclude that HCC may under rare circumstances develop due to chronic AIH dependent liver cirrhosis. Compared to other causes of liver cirrhosis such as chronic viral hepatitis, alcohol, or hemochromatosis, the incidence of HCC is significantly lower. Pathophysiological differences between AIH and chronic viral hepatitis responsible for differences in the incidence of HCC are yet to be further characterized and may lead to new therapeutic concepts in prevention and treatment of liver cancer. | Andreas Teufel Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，5： | 5 |
| 6 | Changing Energy Consumption Behaviour: Individuals' Responsibility and Government Role显示文摘Renewable energy is clearly a very important topic nowadays. The risk and the damage that could be caused by conventional energy resources cannot be hidden. There is an enormous need that people start formulating a better attitude towards renewable energy and change their consumption behaviour. Otherwise, the future of environment and the coming generations are defiantly not going to be promising. This paper discusses the importance of sustainable energy and how the energy related behaviour is created. It presents a framework to influence the current behaviour and push it to be more green oriented. It is also important to know till what limit are governments responsible in this change, and what are the tools that they have to push towards green direction. | Mohamad Aldabas Mario Gstrein Stephanie Teufel | 2015 | Journal of Electronic Science and Technology2015，13，4： | 4 |
| 7 | Blockchain Energy: Blockchain in Future Energy Systems显示文摘The ongoing,in-depth transformation of the electricity sector towards increased use of alternative,renewable energy sources extends beyond a simple decentralisation drive in the electricity market.The transformation process is characterised by the interplay of old and new technologies from the energy sector as well as structural coupling with other sectors,such as the information and communications technology(ICT),enabling the technology transfer as well as market entry by information technology(IT)actors.Blockchain-based technologies have the potential to play a key role in this transition by offering decentralised interfaces and systems as well as an alternative approach to the current organisation form of the energy market.This paper discusses the applicability and prospects for blockchain-based technologies in the energy sector,which are described using the term“blockchain energy”.For the purposes of this study,blockchain energy encompasses all socio-technical and organisational configurations in the energy sector based on the utilisation of the blockchain principle for energy trading,information storage,and/or increased transparency of energy flows and energy services.In the following chapters,the authors present and discuss the current transformation in the electricity market,followed by a review of the different utilisation possibilities for blockchain technologies in the energy sector and a discussion of the barriers and potential for blockchain energy using a transition studies perspective.Finally,the opportunities and risks of blockchain energy are discussed. | Bernd Teufel Anton Sentic Mathias Barmet | 2019 | Journal of Electronic Science and Technology2019，17，4： | 4 |
| 8 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 9 | Association of autoimmune hepatitis and systemic lupus erythematodes:A case series and review of the literature显示文摘Liver test abnormalities have been described in up to 60% of patients with systemic lupus erythematodes(SLE) at some point during the course of their disease.Prior treatment with potentially hepatotoxic drugs or viral hepatitis is commonly considered to be the main cause of liver disease in SLE patients.However,in rare cases elevated liver enzymes may be due to concurrent autoimmune hepatitis(AIH).To distinguish whether the patient has primary liver disease with associated autoimmune clinical and laboratory features resembling SLE- such as AIH- or the elevation of liver enzymes is a manifestation of SLE remains a difficult challenge for the treating physician.Here,we present six female patients with complex autoimmune disorders and hepatitis.Patient charts were reviewed in order to investigate the complex relationship between SLE and AIH.All patients had coexisting autoimmune disease in their medical history.At the time of diagnosis of AIH,patients presented with arthralgia,abdominal complaints,cutaneous involvement and fatigue as common symptoms.All patients fulfilled the current diagnostic criteria of both,AIH and SLE.Remission of acute hepatitis was achieved in all cases after the initiation of immunosuppressive therapy.In addition to this case study a literature review was conducted. | Claudia Beisel Christina Weiler-Normann Andreas Teufel Ansgar W Lohse | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 10 | Genetic association of autoimmune hepatitis and human leucocyte antigen in German patients显示文摘AIM: To report on our large German collective and updated data of 142 patients with autoimmune hepatitis (AIH) type 1. METHODS: Key investigations performed were liver biopsy, serum autoantibodies as well as serum markers such as IgG and elevated transaminases. Antinuclear antigen (ANA) and smooth muscle antigen (SMA) autoantibodies characterized type 1 AIH. Type 3 (AIH) was solely characterized by the occurrence of soluble liver antigen/liver-pancreas antigen (SLA/LP) autoantibodies either with or without ANA or SMA autoantibodies. RESULTS: Most prevalent HLAs were A2 (68 patients, 48%), B8 (63 patients, 44%), C7 (90 patients, 63%), DR3 (49 patients, 38%), DR4 (49 patients, 38%) and DQ2 (42 patients, 30%). Compared to the Italian and North American patients, we found fewer patients with a DQ2 subtype. Furthermore, the B8-DR3-DQ2 human leucocyte antigen (HLA) was also less prominent compared to the North American patients. However, prevalences of B8, DR3, DR4, DR7, DR11 and DR13 were comparable to the Italian and North American patients. Furthermore, we report on an additional subgroup of patients with SLA/LP positive AIH. Generally, in this subgroup of patients the same HLA subtypes were favoured as the AIH type 1. CONCLUSION: Although HLA subtypes were comparable between these three collectives, the German patients were distinct from the Italian and North American patients with respect to DQ2 and from the North American patients with respect to B8-DR3-DQ2HLA. A clinical correlation, e.g. difference in severity or treatability of AIH type 1, has yet to be determined. | Andreas Teufel Markus Wrns Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2006 | World Journal of Gastroenterology2006，12，34： | 2 |
| 11 | Hazards and critical control points of street-vended chat, a regionally popular food in Pakistan显示文摘 | Bryan F L Teufel P | 1992 | J Food Prot1992，55，9： | 1 |
| 12 | New chemotherapeutic strategies in eolorectal caneer显示文摘 | Moehler M Teufel A Galle PR | 2005 | Recent Results Cancer Res2005，165，： | 1 |
| 13 | Coneurrent autoimmune diseases in patients with autoimmune hepatitis显示文摘 | Teufel A Weinmann A Kahaly G J | 2010 | J Clin Gastroen- terol2010，44，3： | 1 |
| 14 | Analyzing Information Security Culture: Increased Trust by an Appropriate Information Security Culture 显示文摘 | Schlienger T Teufel S | 2003 | Database and Expert Systems Applications2003，1，5： | 1 |
| 15 | Re- duced-order entry trajectory planning for acceleration guidance显示文摘 | MEASE K D CHEN D T TEUFEL P | 2002 | Journal of Guidance Control and Dy- namics2002，25，2： | 1 |
| 16 | New chemotherapeutic strategies in colorectal cancer显示文摘 | Moehler M Teufel A Galle PR | 2005 | Recent Results Cancer Res2005，165，： | 1 |
| 17 | Summarizing scientific articles:experiments with relevance and rhetorical status显示文摘 | Teufel S Moens M | | 0，，04： | 1 |
| 18 | Determination of the effective stress law for permeability and deformation in low permeability rocks显示文摘 | Warpinski N R Teufel L W | 1992 | SPE Formation Evaluation1992，7，2： | 1 |
| 19 | Bisphosphonates modulate vital functions of human osteoblasts and affect their interactions with breast- cancer cells显示文摘 | Kaiser T Teufel I Geiger K | 2013 | BreastCancer Res Treat2013，140，1： | 1 |
| 20 | Influence of geologicdiscontinuities on hydraulic fracture propagation显示文摘 | Warpinski N R Teufel L W | 1987 | Journalof Petroleum Technology1987，39，2： | 1 |
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