|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | Use of the mobile nylon bag technique to determine the digestible energy con- tent of traditional and non-traditional feeds for swine显示文摘 | QIAO S Y THACKER P A | 2004 | Archives of Animal Nutrition2004，58，4： | 1 |
| 3 | Epidemiology in the 21 st century: calculation, communication, and intervention显示文摘 | KOPLAN J P THACKER S B LEZIN N A | 1999 | American Journal of Public Health1999，，： | 1 |
| 4 | High-speed switch scheduling for local-area networks显示文摘 | Anderson T E Owicki S S Saxe J B Thacker C P | 1993 | ACM Transactions on Computer Systems1993，11，4： | 1 |
| 5 | Racial differences in the incidence of and risk factors for atrial fibrillation in older adults : tl~e cardiovascular health study 显示文摘 | Jensen P N Thacker E L Dublin S | 2013 | J Am Geriatric Soc2013，61，2： | 1 |
| 6 | Chito-oligosaccharide reduces diarrhea incidence and attenuates the immune response of weaned pigs challenged with Escherichia coli K88显示文摘 | Liu P Piao X S Thacker P A et o1 | 2010 | J Anim Sci2010，88，12： | 1 |
| 7 | Effects of the duration of liquid feeding on performance and nutrient digestibility in weaned pigs显示文摘 | Han Y K Thacker P A Yang J S | 2006 | Asian-Aust J Anita Sci2006，19，： | 1 |
| 8 | Effect of porcine circovirus type 2 infection and replication on activated porcine peripheral blood mononuclear cells in vitro 显示文摘 | YU S HALBUR P G THACKER E | 2009 | Vet Immunol Immunopathol2009，127，34： | 1 |
| 9 | Predicting the global spread of new infectious agents 显示文摘 | Longini I M Jr Fine P E Thacker S B | 1986 | Am J Epidemiol1986，123，： | 1 |
| 10 | Chito-oligosaccharide reduc- es diarrhea incidence and attenuates the immune response of weaned pigs challenged with Eseheriehia eoli K88显示文摘 | Liu P Piao X S Thacker P A | 2010 | Journal of Animal Science2010，88，12： | 1 |
| 11 | High speed switch scheduling for local area networks显示文摘 | T E Anderson S S Owicki J B Saxe C P Thacker | 1993 | ACM Transactions on Computer Systems1993，11，4： | 1 |
| 12 | Detection of intracellular porcine reproductive and respiratory syndrome virus nucleocapsid protein in porcine macrophages by flow cytometry显示文摘 | Thacker E L Halbur P G Paul P S | 1998 | J Vet Diagn Invest1998，10，： | 1 |
| 13 | Characterisation of barley β-amylase for application in maltose production 显示文摘 | Thacker S P Ramamurthy V Kothari R M | 1992 | Starch1992，44，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员