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| 1 | Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis显示文摘AIM To observe the inhibition of antisenseoligonucleotides (asON) phosphorthioate to thetissue inhibitors metalloproteinase-1 (TIMP-1)gene and protein expression in the liver tissue ofimmunologically induced hepatic fibrosis rats.The possibility of reversing hepatic fibrosisthrough gene therapy was observed.METHODS Human serum albumin (HSA) wasused to attack rats, as hepatic fibrosis model, inwhich asONs were used to block the gene andprotein expressing TIMP-1. According to theanalysis of modulator, structure protein, codingseries of TIMP-1 genome, we designed fourdifferent asONs. These asONs were injected intothe hepatic fibrosis models through coccygealvein. The results was observed by RT-PCR formeasuring TIMP-1 mRNA expression,immunohistochemistry and in situ hybridizationfor collagen Ⅰ, Ⅲ, special staining of collagenfiber, and electron microscopic examination.RESULTS Hepatic fibrosis could last within 363days in our modified model. The expressinglevel of TIMP-1 was high during hepatic fibrosisprocess. It has been proved by theimmunohistochemical and the electronmicroscopic examination that the asONphosphorthioate of TIMP-1 could exactly expressin vivo. The effect of colchicine wasdemonstrated to inhibit the expressing level ofmRNA and the content of collagen Ⅰ, Ⅲ in theliver of experimental hepatic fibrosis rats.However, the electron microscopy research andthe pathologic grading of hepatic fibrosisshowed that there was no significant differencebetween the treatment group and the modelgroup (P>0.05).CONCLUSION The experimental rat model ofhepatic fibrosis is one of the preferable modelsto estimate the curative effect of anti-hepaticfibrosis drugs. The asON phosphorthioate ofTIMP-1 could block the gene and proteinexpression of TIMP-1 in the liver of experimentalhepatic fibrosis rats at the mRNA level. It ispossible to reverse hepatic fibrosis, and it isexpected to study a new drug of anti-hepaticfibrosis on the genetic level. Colchicine has verylimited therapeutic effect on hepatic fibrosis,furthermore, its toxicity and side effects areobvious. | Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. | 2001 | World Journal of Gastroenterology2001，7，3： | 73 |
| 2 | 姿态稳定性的定量研究显示文摘应用ST-939人体重心平衡仪对我院职工健康体验的780名进行立位平衡功能测试,重点分析三项参数:外圆面积、轨迹长度,平均速度,结果显示:(1)21-50岁年龄范围内姿态稳定性最佳、其外圆面积小,轨迹短.速度慢.70岁以上年龄组姿态控制力下降。各项参数值较大(P<0.01).(2)视觉影响姿态稳定性.各年龄组三参数闭眼值均大于睁眼(P>001)。(3)性别对姿态控制无明显关系(P>0.05)。 | 李素芳 姜智平 李兵 吕孟新 黄江菊 周建荣0 to 50 years old was better than that of the others.Observing the people of over 70 years old The stabil | 1998 | 重庆医科大学学报1998，23，3： | 29 |
| 3 | Chilli anthracnose disease caused by Colletotrichum species显示文摘Anthracnose disease is one of the major economic constraints to chilli production worldwide, especially in tropical and subtropical regions. Accurate taxonomic information is necessary for effective disease control management. In the Colletotrichum patho-system, different Colletotrichum species can be associated with anthracnose of the same host. Little information is known concerning the interactions of the species associated with the chilli anthracnose although several Colletotrichum species have been reported as causal agents of chilli anthracnose disease worldwide. The ambiguous taxonomic status of Colletotrichum species has resulted in inaccurate identification which may cause practical problems in plant breeding and disease management. Although the management and control of anthracnose disease are still being extensively researched, commercial cultivars of Capsicum annuum that are resistant to the pathogens that cause chilli anthracnose have not yet been developed. This paper reviews the causal agents of chilli anthracnose, the disease cycle, conventional methods in identification of the pathogen and molecular approaches that have been used for the identification of Colletotrichum species. Pathogenetic variation and population structure of the causal agents of chilli anthracnose along with the current taxonomic status of Colletotrichum species are discussed. Future developments leading to the disease management strategies are suggested. | Po Po THAN Haryudian PRIHASTUTI Sitthisack PHOULIVONG Paul W.J.TAYLOR Kevin D.HYDE | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，10： | 15 |
| 4 | Preliminary experience with drug-coated balloon angioplasty in primary percutaneous coronary intervention显示文摘We evaluated the clinical feasibility of using drugcoated balloon(DCB) angioplasty in patients undergoingprimary percutaneous coronary intervention(PPCI). Between January 2010 to September 2014,89 STelevation myocardial infarction patients(83% male,mean age 59 ± 14 years) with a total of 89 coronary lesions were treated with DCB during PPCI. Clinical outcomes are reported at 30 d follow-up. Left anterior descending artery was the most common target vessel for PCI(37%). Twenty-eight percent of the patients had underlying diabetes mellitus. Mean left ventricular ejection fraction was 44% ± 11%. DCB-only PCI was the predominant approach(96%) with the remaining 4% of patients receiving bail-out stenting. Thrombolysis in Myocardial Infarction(TIMI) 3 flow was successfully restored in 98% of patients. An average of 1.2 ± 0.5 DCB were used per patient,with mean DCB diameter of 2.6 ± 0.5 mm and average length of 23.2 ± 10.2 mm. At 30-d follow-up,there were 4 deaths(4.5%). No patients experienced abrupt closure of the infarctrelated artery and there was no reported target-lesion failure. Our preliminary experience showed that DCB angioplasty in PPCI was feasible and associated with a high rate of TIMI 3 flow and low 30-d ischaemic event. | Hee Hwa Ho Julian Tan Yau Wei Ooi Kwok Kong Loh Than Htike Aung Nwe Tun Yin Dasdo Antonius Sinaga Fahim Haider Jafary Paul Jau Lueng Ong | 2015 | World Journal of Cardiology2015，7，6： | 14 |
| 5 | Prevalence of Helicobacter pylori infection and atrophic gastritis in patients with dyspeptic symptoms in Myanmar显示文摘AIM: To survey the detailed analyses for Helicobacter pylori(H. pylori) infection and gastric mucosal status in Myanmar.METHODS: A total of 252 volunteers with dyspeptic symptoms(155 female and 97 male; mean age of 43.6 ± 14.2 years) was participated in Yangon and Mandalay. The status of H. pylori infection was determined based on 5 different tests including rapid urease test, culture, histology, immunohistochemistry and serology. Histological scores were evaluated according to the update Sydney system and the Operative Link for Gastritis Assessment system. Pepsinogen(PG)Ⅰand PG Ⅱ were measured using enzyme-linked immunosorbent assays.RESULTS: The overall prevalence of H. pylori infectionwas 48.0%. There was no relationship between age and infection rate. Even in young group(less than 29 years old), the H. pylori infection rate was relatively high(41.9%). The prevalence of H. pylori infection was significantly higher in Yangon than that of Mandalay. H. pylori infection was significantly associated with the presence of gastric mucosal atrophy. All 7 subjects with peptic ulcer were infected with H. pylori. Although H. pylori-positive subjects showed stronger gastritis than H. pylori-negative subjects, most cases had mild gastritis.CONCLUSION: We revealed the prevalence of H. pylori infection in patients with dyspeptic symptoms in Myanmar. The H. pylori infection was a risk factor for peptic ulcer and stronger gastritis. | Thein Myint Seiji Shiota Ratha-korn Vilaichone New Ni Than Than Aye Miyuki Matsuda Trang Thi Huyen Tran Tomohisa Uchida Varocha Mahachai Yoshio Yamaoka | 2015 | World Journal of Gastroenterology2015，21，2： | 10 |
| 6 | Issues and mitigations of wind energy penetrated network:Australian network case study显示文摘Longest geographically connected Australian power system is undergoing an unprecedented transition,under the effect of increased integration of renewable energy systems. This change in generation mix has implications for the whole interconnected system designs, its operational strategies and the regulatory framework. Frequency control policies about real-time balancing of demand and supply is one of the prominent and priority operational challenge requiring urgent attention. This paper reviews the Australian electricity market structure in presence of wind energy and its governance. Various issues related to increased wind generation systems integration are discussed in detail. Currently applied mitigations along with prospective mitigation methods requiring new or improved policies are also discussed. It is concluded that developing prospective frequency regulation ancillary services market desires further encouraging policies from governing authority to keep pace with current grid transition and maintain its security. | Asma AZIZ Aman Maung Than OO Alex STOJCEVSKI | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，6： | 4 |
| 7 | 拔牙后不同类型骨缺损行位点保存术骨量恢复的CBCT比较研究显示文摘目的:探讨拔牙位点保存术在恢复骨缺损中的作用以及对不同类型骨缺损可能存在的骨增量差异。方法:选取广西医科大学附属口腔医院种植科就诊的患者80例,分为实验组和对照组,每组40例。实验组在行拔牙术的同时行拔牙位点保存术,对照组拔牙术后不填充骨替代材料;两组再根据拔牙窝牙槽骨缺损的类型分为4个亚组:拔牙窝为一壁骨缺损(A组)、二壁骨缺损(B组)、三壁骨缺损(C组)、四壁骨缺损(D组)。实验组无膜拔牙后采用脱矿的牛骨混合10%骨胶原(Bio-Oss Collagen?)保存牙槽骨,所有研究对象拔牙术前行锥形束计算机断层扫描(CBCT),6个月后随访。结果:实验组平均骨高度较术前增加,牙槽骨平均宽度较估计原始骨轮廓恢复72.79%~88.08%,对照组牙槽骨平均宽度较估计原始骨轮廓恢复57.20%~84.91%。结论:拔牙位点保存术对牙槽骨的恢复具有明显效果,可以有效减少拔牙后牙槽骨骨吸收。 | Ye Myat Thu 李晓 蒋延波 Aung Than Oo 唐礼 | 2020 | 广西医科大学学报2020，37，1： | 4 |
| 8 | Application of a Neural Network Technique for Prediction of the Water Quality Index in the Dong Nai River, Vietnam显示文摘 | Nguyen Hien Than Che Dinh Ly Pham Van Tat Nguyen Ngoc Thanh | 2016 | Journal of Environmental Science and Engineering(B)2016，5，7： | 3 |
| 9 | Hepatitis C virus therapy with peg-interferon and ribavirin in Myanmar: A resource-constrained country显示文摘AIM To investigate peg-interferon(peg-IFN) and ribavirin(RBV) therapy in Myanmar and to predict sustained virologic response(SVR).METHODS This single-center, open-label, study was conducted in Myanmar between 2009 and 2014. A total of 288 patients infected with HCV genotypes 1, 2, 3 and 6 were treated with peg-IFN alpha-2a(180 μg/wk) or alpha-2b(50 to 100 μg as a weight-based dose) and RBV as a weight-based dose(15 mg/kg/d). Treatment duration was 48 wk for genotypes 1 and 6, 24 wk for genotype 2, and 24 or 48 wk for genotype 3 based on rapid virologic response(RVR). Those co-infected with hepatitis B received 48 wk of therapy.RESULTS Overall, SVR was achieved for 82% of patients and the therapy was well tolerated. All patients achieved SVR at equivalent rates regardless of HCV genotype(P = 0.314). Low fibrosis scores(P < 0.001), high baseline albumin levels(P = 0.028) and low baseline viral loads(P = 0.029) all independently predicted SVR. On the other hand, IL-28 B TT and CC genotypes were not found to significantly predict SVR(P = 0.634; P = 0.618). Among those who completed treatment, the occurrence of RVR showed a > 96% positive predictive value for achieving SVR. Treatment duration did not significantly impact the likelihood of achieving SVR for patients infected with genotype 3 HCV(P = 0.371). The most common adverse events were fatigue(71%) and poor appetite(60%). Among patients with genotype 3 HCV, more patients in the 48-wk treatment group required erythropoietin than in the 24-wk treatment group(61.1% vs 49.2%).CONCLUSION SVR rates were high with peg-IFN and RBV therapy in Myanmar. Fibrosis scores, baseline albumin, HCV RNA levels and RVR independently predicted SVR. | Naomi Khaing Than Hlaing Debolina Banerjee Robert Mitrani Soe Htet Arker Kyaw San Win Nyan Lin Tun Zaw Thant Khin Maung Win K Rajender Reddy | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 10 | A new species of Crocodile Newt, genus Tylototriton(Amphibia, Caudata, Salamandridae) from the mountains of Kachin State, northern Myanmar显示文摘We describe a new species of the genus Tylototriton from Ingyin Taung Mt.,Mohnyin Township,Kachin State,Myanmar,based on morphological and molecular evidence.The new species is assigned to the subgenus Tylototriton s.str.and is clearly distinct from all known congeners by the following characters:medium body size;thin,long tail,lacking lateral grooves;rough skin;truncate snout;wide,protruding supratemporal bony ridges on head,beginning at anterior corner of orbit;weak,almost indistinct sagittal ridge;long,thin limbs,broadly overlapping when adpressed along body;distinct,wide,non-segmented vertebral ridge;13 or 14 rib nodules;brown to darkbrown background coloration with dull orange-brown to yellowish-brown markings on labial regions,parotoids,rib nodules,whole limbs,vent,and ventral tail ridge.We also briefly discuss biogeography and species diversity of the genus Tylototriton in Myanmar. | Than Zaw Paw Lay Parinya Pawangkhanant Vladislav A.Gorin Nikolay A.Poyarkov,Jr | 2019 | Zoological Research2019，40，3： | 2 |
| 11 | Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria显示文摘 | Derick Han Lily Dara Sanda Win Tin Aung Than Liyun Yuan Sadeea Q. Abbasi Zhang-Xu Liu Neil Kaplowitz | 2013 | Trends in Pharmacological Sciences2013，，4： | 2 |
| 12 | Circulating cardiac autoantibodies in dilated cardiomyopathy and myocarditis:pathogenitic and clinical significance显示文摘 | Cafonio AL Mahon NJ Than F | 2002 | Eur J Heart Fail2002，4，4： | 1 |
| 13 | Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics显示文摘 | Becker GL Sielaff F Than ME | 2010 | J Med Chem2010，53，3： | 1 |
| 14 | Elevated Serum Arginase Activity Levels in Patients with Breast Cancer显示文摘 | Muhammet Fevz? Polat Sey?than Tays? Sev?n? Polat Abdullah B?yük Ebubek?r Bakan | 2003 | Surgery Today2003，，9： | 1 |
| 15 | Modes and cutoff frequencies of crossed rectangular waveguides显示文摘 | THAN Q C | 1977 | IEEE Transaction on Microwave Theory and Technique1977，25，7： | 1 |
| 16 | Complete genomic characteriza- tion of cell culture adapted human G12P 显示文摘 | Than V T Le VP Lim I | 2011 | Virus Genes2011，42，3： | 1 |
| 17 | Plasma value load evaluation in relation to disease progression in HIV- infected children显示文摘 | Tetali S Bakshi S Than S | 1998 | AIDS Res Hum Retroviruses1998，14，7： | 1 |
| 18 | Plaeental protein13(galeetin-13)has deereased plaeental expression but inereased shedding and maternal serum concentrations in Patients presenting with preterm preeclampsia and HELLP syndrome显示文摘 | Than N Abdul Rahman O Magenheim R | 2008 | Virehows Arch2008，453，4： | 1 |
| 19 | Radiation safety and spine surgery:systematic review of exposure limits and methods to minimize radiation exposure 显示文摘 | Srinivasan D Than KD Wang AC | 2014 | World Neurosurg2014，82，6： | 1 |
| 20 | Uhrafast thermoelasticity for short-pulse laser heating显示文摘 | CHEN J K BERAUN J E THAN C L | 2004 | Int J Eng Sci2004，42，8： | 1 |
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