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| 1 | Circulating hTERT mRNA as a tumor marker in cholangiocarcinoma patients显示文摘瞄准:调查人的 telomerase 颠倒 transcriptase (hTERT ) 在 cholangiocarcinoma 病人的浆液的 mRNA。方法:三十三个 cholangiocarcinoma 病人,四十一个良性的胆道疾病病人和十个健康志愿者的浆液为由即时反向的 transcriptase 聚合酶链反应(RT-PCR ) 的 hTERT mRNA 的表示镇定、分析。我们然后检验了在浆液 hTERT mRNA 的价值和 cholangiocarcinoma 的病理学的阶段之间的关联。结果:hTERT mRNA 在 33 中的 28 个被检测(84.85%) 从 cholangiocarcinoma 浆液获得了病人,(21.9%) 41 中的 9 个从良性的胆道疾病病人浆液获得了。hTERT mRNA 没在从健康志愿者获得的任何浆液被检测。在另一方面普通肿瘤标记, CA19-9 在 33 中的 20 个被检测(60.6%) 从 cholangiocarcinoma 浆液获得了病人,(19.5%) 41 中的 8 个从良性的胆道疾病病人浆液获得了。然而,没有关联浆液 hTERT mRNA 和肿瘤阶段在礼品之间被发现。结论:这些结果显示传播 hTERT mRNA 的察觉在几乎所有 cholangiocarcinoma 病人被识别。它提供一个新奇肿瘤标记,它能为 cholangiocarcinoma 的诊断被用作互补研究。 | Kawin Leelawat Surang Leelawat Thawee Ratanachu-Ek Somboon Trubwongchareon Jerasak Wannaprasert Saad Tripongkaruna Suchart Chantawibul Panadda Tepaksorn | 2006 | World Journal of Gastroenterology2006，12，26： | 10 |
| 2 | Extremely high prevalence of Helicobacter pylori infection in Bhutan显示文摘AIM: To revealed the prevalence of Helicobacter pylori (H. pylori ) infection in the Bhutanese population. METHODS: We recruited a total of 372 volunteers (214 females and 158 males; mean age of 39.6 ± 14.9 years) from three Bhutanese cities (Thimphu, Punaka, and Wangdue). The status of H. pylori infection was determined based on five different tests: the rapid urease test (CLO test), culture, histology, immunohistochemistry (IHC), and serum anti H. pylori -antibody. RESULTS: The serological test showed a significantly higher positive rate compared with the CLO test, culture, histology and IHC (P < 0.001, P < 0.001, P=0.01, and P=0.01, respectively). When the subjects were considered to be H. pylori positive in the case of at least one test showing a positive result, the overall prevalence of H. pylori infection in Bhutan was 73.4%. The prevalence of H. pylori infection significantly decreased with age (P < 0.01). The prevalence of H. pylori infection was lower in Thimphu than in Punakha and Wangdue (P=0.001 and 0.06, respectively). The prevalence of H. pylori infection was significantly higher in patients with peptic ulcers than in those with gastritis (91.4% vs 71.3%, P=0.003). CONCLUSION: The high incidence of gastric cancer in Bhutan may be attributed to the high prevalence of H. pylori infection. | Ratha-korn Vilaichone Varocha Mahachai Seiji Shiota Tomohisa Uchida Thawee Ratanachu-ek Lotay Tshering Nguyen Lam Tung Toshio Fujioka Masatsugu Moriyama Yoshio Yamaoka | 2013 | World Journal of Gastroenterology2013，19，18： | 8 |
| 3 | Prospective study of MMP7 serum levels in the diagnosis of cholangiocarcinoma显示文摘AIM: To determine whether the serum level of matrix metalloproteinase-7 (MMP7) has the potential to diagnosis cholangiocarcinoma from benign biliary tract diseases. METHODS: This study was performed according to the PRoBE (a prospective-specimen-collection, retrospectiveblinded-evaluation) design. A total of 187 patients with obstructive jaundice were consecutively enrolled. After the diagnostic status of these patients was ascertained, their levels of serum MMP7 were assayed and compared with serum carbohydrate antigen 19-9 (CA19-9). This was conducted in a blinded case (cholangiocarcinoma)control (benign biliary tract disease) setup. RESULTS: MMP7 and CA19-9 serum levels were significantly elevated in cholangiocarcinoma patients (P < 0.001). The area under the curve (AUC) from a receiver operating characteristic (ROC) curve analysis for thediagnosis of cholangiocarcinoma, using MMP7 was more accurate than CA19-9 (AUC = 0.84, 95% CI: 0.778-0.903 for MMP7 and AUC = 0.79, 95% CI: 0.708-0.868 for CA19-9). The sensitivity and specificity of serum MMP7 (cut-off value of 5.5 ng/mL) was 75% and 78%, respectively, while the sensitivity and specificity of serum CA19-9 (cut-off value of 100 U/mL) was 68% and 87%, respectively. CONCLUSION: Serum values of MMP7 and CA19-9 appear to be useful biomarkers for differentiating cholangiocarcinoma from benign biliary tract obstructive diseases. | Kawin Leelawat Siriluck Narong Jerasak Wannaprasert Thawee Ratanashu-ek | 2010 | World Journal of Gastroenterology2010，16，37： | 7 |
| 4 | Antibiotics resistance rate of Helicobacter pylori in Bhutan显示文摘AIM:To survey the antibiotic resistance pattern of Helicobacter pylori(H.pylori)strains isolated from Bhutanese population.METHODS:We isolated 111 H.pylori strains from the gastric mucosa of H.pylori-infected patients in Bhutan in 2010.The Epsilometer test was used to determine the minimum inhibitory concentrations(MICs)of amoxicillin(AMX),clarithromycin(CLR),metronidazole(MNZ),levofloxacin(LVX),ciprofloxacin(CIP),and tetracycline(TET).RESULTS:Nineteen of the isolated H.pylori strains were susceptible to all antibiotics tested.The isolated strains showed the highest rate of antibiotic resistance to MNZ(92/111,82.9%).Among the 92 MNZresistant strains,74 strains(80.4%)showed high-level resistance(MIC≥256 g/mL).Three strains were resistance to LVX(2.7%).These strains were also resistance to CIP.None of the strains showed resistance to CLR,AMX and TET.CONCLUSION:CLR-based triple therapy is a more effective treatment approach over MNZ-based triple therapy for H.pylori infection in Bhutan. | Ratha-korn Vilaichone Yoshio Yamaoka Seiji Shiota Thawee Ratanachu-ek Lotay Tshering Tomohisa Uchida Toshio Fujioka Varocha Mahachai | 2013 | World Journal of Gastroenterology2013，19，33： | 6 |
| 5 | Role of ciprofloxacin in patients with cholestasis after endoscopic retrograde cholangiopancreatography显示文摘AIM: To determine the role of ciprofloxacin in reducing cholangitis in cholestatic patients with adequate biliary drainage after endoscopic retrograde cholangiopancreatography (ERCP). METHODS: A randomized, controlled trial was performed in 48 cholestatic patients at Rajavithi Hospital (Tertiary Referral Center for ERCP: 600 cases per year). All the 48 patients received 200 mg ciprofloxacin intravenous injection for 30 min before starting any procedures, and then were randomly divided in two groups. Twenty-two patients in study group continually received ciprofloxacin until 48 h after ERCP. Causes of biliary obstruction, bacteriology of bile and blood (in cholangitis) and clinical cholangitis were recorded. RESULTS: Forty-eight patients were enrolled and divided into continuous ciprofloxacin treatment group (n = 22) and discontinuous ciprofloxacin treatment group (n = 26). During ERCP, stones were found in 22 patients, malignant diseases in 24 patients and other pathologic lesions in 5 patients. One (4.5%) of the 22 patients who received ciprofloxacin and 2 (6.3%) of the 26 patients who discontinued ciprofloxacin after ERCP developed cholangitis (relative risk = 0.71; 95% CI = 0.14-3.65; P = 0.88). Bacterobilia was found in 27 (56.3%) out of 48 patients. E. coli and Streptococcus viridans were the most common organisms. CONCLUSION: Continual use of ciprofloxacin in patients with cholestasis after adequate biliary drainage procedures plays no role in reducing cholangitis. | Thawee Ratanachu-ek Pitchaya Prajanphanit Kawin Leelawat Suchart Chantawibul Sukij Panpimanmas Somboon Subwongcharoen Jerasak Wannaprasert | 2007 | World Journal of Gastroenterology2007，13，2： | 5 |
| 6 | Seroprevalence of Helicobacter pylori infection and gastric mucosal atrophy in Bhutan, a country with a high prevalence of gastric cancer显示文摘 | Seiji Shiota Varocha Mahachai Ratha-korn Vilaichone Thawee Ratanachu-ek Lotay Tshering Tomohisa Uchida Osamu Matsunari Yoshio Yamaoka | 2013 | Journal of Medical Microbiology2013，，1： | 2 |
| 7 | A sia– P acific consensus recommendations for endoscopic and interventional management of hilar cholangiocarcinoma显示文摘 | Rungsun Rerknimitr Phonthep Angsuwatcharakon Thawee Ratanachu‐ek Christopher J L Khor Ryan Ponnudurai Jong Ho Moon Dong Wan Seo Linda Pantongrag‐Brown Apichat Sangchan Pises Pisespongsa Thawatchai Akaraviputh Nageshwar D Reddy Amit Maydeo Takao Itoi Nonth | 2013 | J Gastroenterol Hepatol2013，，4： | 1 |
| 8 | Increasing Incidence of Hip Fracture in Chiang Mai, Thailand显示文摘 | Prasit Wongtriratanachai Sirichai Luevitoonvechkij Thawee Songpatanasilp Siripoj Sribunditkul Taninnit Leerapun Sompant Phadungkiat Sattaya Rojanasthien | 2012 | Journal of Clinical Densitometry2012，，： | 1 |
| 9 | Seroprevalence of Helicobacter pylori infection and gastric mucosal atrophy in Bhutan, a country with a high prevalence of gastric cancer显示文摘 | Seiji Shiota Varocha Mahachai Ratha-korn Vilaichone Thawee Ratanachu-ek Lotay Tshering Tomohisa Uchida Osamu Matsunari Yoshio Yamaoka | 2013 | Journal of Medical Microbiology (Pt )2013，，10： | 1 |
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