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| 1 | Pharmacokinetics and toxicology of therapeutic proteins:Advances and challenges显示文摘Significant progress has been made in understanding pharmacokinetics (PK),pharmacodynamics (PD),as well as toxicity profiles of therapeutic proteins in animals and humans,which have been in commercial development for more than three decades.However,in the PK arena,many fundamental questions remain to be resolved.Investigative and bioanalytical tools need to be established to improve the translation of PK data from animals to humans,and from in vitro assays to in vivo readouts,which would ultimately lead to a higher success rate in drug development.In toxicology,it is known,in general,what studies are needed to safely develop therapeutic proteins,and what studies do not provide relevant information.One of the major complicating factors in nonclinical and clinical programs for therapeutic proteins is the impact of immunogenicity.In this review,we will highlight the emerging science and technology,as well as the challenges around the pharmacokinetic-and safety-related issues in drug development of mAbs and other therapeutic proteins. | Yulia Vugmeyster Frank-Peter Theil Leslie A Khawli Michael W Leach | 2012 | World Journal of Biological Chemistry2012，3，4： | 3 |
| 2 | Carebral and basilar artery thrombosis,following cervical spinal injury显示文摘 | Niedeggen A Rommel O Theile A | 1998 | Eentralbl Neurochir1998，60，1： | 1 |
| 3 | 显示文摘 | Kusano E Theil J A | 1989 | J Vac Sci Technol1989，7，3： | 1 |
| 4 | Cevebral and banilar artery thrembosis following cerrical spinal injury显示文摘 | Niedeggen A Rommel O Theile A | 1999 | J Neurochir1999，60，1： | 1 |
| 5 | On Pure and Mixed Statistical Estimation in Economics显示文摘 | Theil H Goldberger A S | 1961 | International Economic Review1961，，2： | 1 |
| 6 | IL-7 abrogates suppressive activity of human CD4+CD25+FOXP3+regulatory T cells and allows expansion of alloreactive and autoreactive T cells显示文摘 | Heninger AK Theil A Wilhelm C | 2012 | J Immunol2012，189，12： | 1 |
| 7 | Cell culture propaga- tion of porcine rotavirus (reovirus-like agent) 显示文摘 | THEIL K W BOHL E H AGNES A G | 1977 | Am J Vet Res1977，38，11： | 1 |
| 8 | STEP(satellite test of the equivalence principle)显示文摘 | Sumner T J Anderson J Blaser J P Cruise A M Damour T Dittus D Everitt C W F Fou-lon B Jafry Y Kent B J Lockerbie N Loeffler F Mann G Mester J Pegrum C ReinhardtR Sandford M Scheicher A Speake C C Torii R Theil S Touboul P Vitale S Vodel W Worden P W | 2007 | Advance in Space Re-search2007，39，2： | 1 |
| 9 | Deposition of vanadium oxide by direction-current magnetron rective sputtering显示文摘 | E Kusano J A Theil John A Thomton | 1988 | J Vac Sci Technol1988，6，： | 1 |
| 10 | Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia:a Southwest Oncology Group/Eastern Cooperative Oncology Group Study显示文摘 | Slovak ML Kopecky K J Cassileth PA Harrington DH Theil KS Mohamed A Paietta E Willman CL Head DR Rowe JM Forman SJ Appelbaum FR | 2000 | Blood2000，96，13： | 1 |
| 11 | Surface properties of quasicrystals显示文摘 | C J Jenks P A Theil | 1997 | MRS Bulletin1997，22，11： | 1 |
| 12 | Expression, exon-intron organization, and chromosome mapping of the human sodium iodide symporter 显示文摘 | Smanik P A Ryu K Y Theil K S | 1997 | Endocrinology1997，138，： | 1 |
| 13 | Vanadium reactive magnetron sputtering in mixed Ar/O2 discharges显示文摘 | Theil J A Kusano E Rockett A | 1997 | Thin Solid Films1997，298，12： | 1 |
| 14 | IL-7 abrogates suppressive activity of human CD4~CD25~FOXP3~regulatory T cells and allows expansion of alloreactive and autoreactive T cells显示文摘 | Heninger AK Theil A Wilhelm C | 2012 | J Immunol2012，189，12： | 1 |
| 15 | On pure and mixed estimation in econometrics 显示文摘 | THEIL H GOLDBERGER A S | 1961 | International Economic Review1961，2，： | 1 |
| 16 | Culture and successful eradication of Helieobaeter pylori from het- erotopic gastric mucosa 显示文摘 | Wuppenhorst N Viebahn B Theile A | 2012 | Z Gastroenterol2012，50，7： | 1 |
| 17 | Structural and functional partitioning of bread wheat chromosome 3B 显示文摘 | CHOULET F ALBERTI A THEIL S | 2014 | Science2014，345，12： | 1 |
| 18 | Free tensor fasciae latae flap reconstruction of defects of the chest and abdominal wall: selection of recipient vessels 显示文摘 | Penington A J Theile DR MacLeod AM | 1996 | Scand J Plast Reconstr Surg Hand Surg1996，30，4： | 1 |
| 19 | Culture and successful eradication of helicobacter pylori from heterotopic gastric mucosa显示文摘 | Wuppenhorst N Viebahn B Theile A | 2012 | Z Gastroentero12012，50，7： | 1 |
| 20 | Cerebral and basilar artery throm bosis,following cerviical spinal injury显示文摘 | Niiedeggen A Rommel O Theile A | 1998 | Entralbl Neruochir1998，60，1： | 1 |
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