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	题名	作者	年代	出处	被引量
1	Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure.	Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz	2021	Bioactive Materials2021，6，12：	7
2	Willfulness Versus Expectation: A Promisor - Based Defense of Willful Breach Doctrine 显示文摘	:eve Thel Peter Siegelman	2009	Michigan Law Review2009，，6：	1
3	Neurodegeneration in Alzheimer disease:role of amyloid precursor protein and presenilin 1 intracellular signaling显示文摘	Nizzari M Thel ung S Corsaro A		0，，：	1
4	Infection with clas-sical swine fever virus: effects on phenotype and im- mune responsiveness of porcine T lymphocytes显示文摘	Paul Y T Konig M Thel H J	1998	J Gen Virol1998，79，1：	1
5	Cardiopulmonary resuscitation: historical perspective to recent investigations显示文摘	Thel MC O'Connor CM	1999	Am Heart J1999，137，1：	1
6	Cardiopulmonary resuscitation:historical perspective to recent investigations显示文摘	Thel MC Connor CM	1999	Am Heart J1999，137，1：	1
7	Neurodegeneration in Alzheimer disease:role of amyloid precursor protein and presenilin 1 intracellular signaling显示文摘	Nizzari M Thel ung S Corsaro A		0，，：	1
8	Mode of action and application of Scorpion primers to mutation detection 显示文摘	THEL WELL N MILLINGTON S SOLINAS A	2000	Nucleic Acids Res2000，28，：	1
9	Cardiopulmonary resuscitation: histori- cal perspective to recent investigations 显示文摘	Thel MC O'Connor CM	1999	Am Heart J1999，137，1：	1
10	Willfulness versus expectation:a promisor-based defense of willful breach doctrine 显示文摘	STEVE THEL PETER SIEGELMAN	2009	Michigan Law Review2009，107，8：	1
11	The Original Conception of Section 10(b) of the Securities Exchange Act显示文摘	Thel S	1990	Stanford Law Review1990，42，2：	1
12	Cardiopulmonary resuscitation:historical perspective to recent investigations显示文摘	Thel MC Connor CM	1999	Am Heart J1999，137，1：	1
13	Cardiopulmonary resuscitation:historical perspective to recent investigations显示文摘	Thel M C O'Connor C M	1999	Am Heart J1999，137，1：	1
14	Acute and chronic renal failure in liver transplantation显示文摘	Me Cauley J Van Thel DH Starzl TE	1990	Nephron1990，55，：	1
15	Cardiopulmonary resuscitation: historical perspective to recent investigations显示文摘	Thel MC O'Connor CM	1999	Am Heart J1999，137，1：	1
16	Peptidyl-prolyl cis-trans isomerases,a superfamily of ubiquitous folding catalysts显示文摘	Gthel SF Marahiel MA	1999	Cell Mol Life Sci1999，55，3：	1
17	Cardiopulmonary resuscitation:historical perspective to recent investigations显示文摘	Thel MC O ' Connor CM	1999	Am Heart J1999，137，1：	1
18	Cardiopulmanary resuscitation : historical perspective to recent investigations显示文摘	Thel MC Oconnor CM	1999	Am Heart J1999，137，1：	1
19	Cardiopulmonary resuscitation: historical perspective to recent investgation显示文摘	Thel MC O' Connor CM	1999	Am Heart J1999，137，1：	1
20	Cardiopulmonary resuscitation:historical perspective to recent investigations显示文摘	Thel MC Connor CM	1999	Am Heart1999，137，1：	1

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