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| 1 | Gene therapy progress and prospects: Fetal gene therapy-first proofs of conceptsome adverse effects 显示文摘 | Coutelle C Themis M Waddington S N | 2005 | Gene Ther2005，12，： | 1 |
| 2 | Retroviral gene transfer to the liver in vivo during triodothyronine induced hyperplasia 显示文摘 | Forties S J Themis M Alison M R | 1998 | Gene Therapy1998，5，5： | 1 |
| 3 | Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro 显示文摘 | Tolmachov O Ma Y L Themis M | 2006 | BMC Cardiovasc Disord2006，6，： | 1 |
| 4 | Resistance to azoxystrobin in Aternaria isolates from pistachio in California 显示文摘 | Ma Z H Dan F Themis J M | 2003 | Pesticide Biochemistry and Physiology2003，，66： | 1 |
| 5 | Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro 显示文摘 | Tolmachov O Ma Y L Themis M | 2006 | BMC Cardiovasc Disord2006，6，： | 1 |
| 6 | Excess nitrogen raises nectarine susceptibility to disease and insects显示文摘 | KENT M D JOHNSON R S THEMIS J M | 1995 | California Agriculture1995，49，4： | 1 |
| 7 | Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro显示文摘 | Tolmachov O Ma YL Themis M | 2006 | BMC Cardiovasc Disord2006，6，： | 1 |
| 8 | Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1显示文摘 | Eden ER Patel DD Sun XM Burden JJ Themis M Edwards M | 2002 | J Clin Invest2002，110，11： | 1 |
| 9 | Characterization of long-term survival of syngeneic hepatocytes in rat peritoneum 显示文摘 | SELDEN C CASBARD A THEMIS M | 2003 | Cell Transplant2003，12，： | 1 |
| 10 | Genetic Structure of Botrytis cinerea populations from different host plants in Califomia显示文摘 | Ma Z H Themis J M | 2005 | Plant Disease2005，89，10： | 1 |
| 11 | Effect of amniotic fluid on cationic lipid mediated transfection and viral infection显示文摘 | Douar AM Themis M Friedman T | 1996 | Gene Therap1996，3，： | 1 |
| 12 | Fetal gene delivery in mice by intra-amniotic administration of retroviral producer cells and adenovirus显示文摘 | Douar AM Adebakin S Themis M | 1997 | Gene Ther1997，4，： | 1 |
| 13 | Retroviral gene transfer to the liver invivo during tri-idiothyronine induced hyperplasia 显示文摘 | Forbes SJ Themis M Alison MR | 1998 | Gene Therapy1998，5，： | 1 |
| 14 | Therapeutic concentrations of human factor IX in mice after gene delivery into the amniotic cavity:A model for the prenatal treatment of haemophilia B显示文摘 | Schneider H Adebakin S Themis M | 1999 | J Gene Med1999，，： | 1 |
| 15 | Sensitivity of Botryosphaeria dothidea from California pistachio to tebuconazole 显示文摘 | MA Zhong-hua DAVID P M DAN FELTS THEMIS J M | 2002 | Crop Protection2002，，21： | 1 |
| 16 | Oncogenesis following delivery of a non-primate lentiviral gene therapy vector to fetal mice显示文摘 | Themis M Waddington S N Schmidt M | 2005 | Mol Ther2005，12，： | 1 |
| 17 | Gut dysbiosis and systemic inflammation promote cardiomyocyte abnormalities in an experimental model of steatohepatitis显示文摘BACKGROUND Cardiovascular disease is the main cause of death in metabolic-associated fatty liver disease,and gut microbiota dysbiosis is associated with both of them.AIM To assess the relationship between gut dysbiosis and cardiovascular risk(CVR)in an experimental model of steatohepatitis.METHODS Adult male Sprague-Dawley rats were randomized to a control group(n=10)fed a standard diet and an intervention group(n=10)fed a high-fat choline-deficient diet for 16 wk.Biochemical,molecular,hepatic,and cardiac histopathology.Gut microbiota variables were evaluated.RESULTS The intervention group had a significantly higher atherogenic coefficient,Castelli’s risk index(CRI)-I and CRI-II,interleukin-1β,tissue inhibitor of metalloproteinase-1(all P<0.001),monocyte chemoattractant protein-1(P=0.005),and plasminogen activator inhibitor-1(P=0.037)than the control group.Gene expression of miR-33a increased(P=0.001)and miR-126(P<0.001)decreased in the intervention group.Steatohepatitis with fibrosis was seen in the intervention group,and heart computerized histological imaging analysis showed a significant decrease in the percentage of cardiomyocytes with a normal morphometric appearance(P=0.007),reduction in the mean area of cardiomyocytes(P=0.037),and an increase of atrophic cardiomyocytes(P=0.007).There were significant correlations between the cardiomyocyte morphometry markers and those of progression and severity of liver disease and CVR.The intervention group had a lower Shannon diversity index and fewer changes in the structural pattern of gut microbiota(both P<0.001)than controls.Nine microbial families that are involved in lipid metabolism were differentially abundant in intervention group and were significantly correlated with markers of liver injury and CVR.CONCLUSION The study found a link between gut dysbiosis and significant cardiomyocyte abnormalities in animals with steatohepatitis. | Larisse Longo Pabulo Henrique Rampelotto Eduardo Filippi-Chiela Valessa Emanoele Gabriel de Souza Fernando Salvati Carlos Thadeu Cerski Themis Reverbel da Silveira Cláudia P Oliveira Carolina Uribe-Cruz Mário ReisÁlvares-da-Silva | 2021 | World Journal of Hepatology2021，13，12： | 1 |
| 18 | Gene therapy progress and prospects: Fetal gene therapy-first proofs of conceptsome adverse effects显示文摘 | Coutelle C Themis M Waddington S N | 2005 | Gene Ther2005，12，： | 1 |
| 19 | Fetal scmatic gene therapy显示文摘 | DOUAR A M THEMIS M COUTELLE C | 1996 | Mol Hum Reprod1996，2，9： | 1 |
| 20 | Gene therapy progress and prospects: Fetal gene therapy - first proofs of concept - some adverse effects显示文摘 | Coutelle C Themis M Waddington S N | 2005 | Gene Ther2005，12，： | 1 |
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