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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | The fimctional anatomy of Kager's fat pad in relation to retrocalcaneal problems and other hindfoot disorders显示文摘 | Theobald P Bydder G Dent C | 2006 | J Anat2006，208，1： | 1 |
| 3 | Developmental and reproductive toxicity ofdioxins and related compounds:cross-species comparisons显示文摘 | Peterson R E Theobald H M Kimmel G L | 1993 | Crit RevToxicol1993，23，： | 1 |
| 4 | Xenoestrogens in the River Elbe and its tributaries显示文摘 | Stachel B Ehrhom U Heemken O P Lepom P Reincke H Sawal G Theobald N | 2003 | Environmental Pollution2003，124，3： | 1 |
| 5 | The functional anatomy of Kager's fat pad in relation to retrocalcaneal problems and other hindfoot disorders显示文摘 | Theobald P Bydder G Dent C | 2006 | J Anat2006，208，1： | 1 |
| 6 | Semantic similarity search on semistructured data with the XXL search engine显示文摘 | Schenkel R Theobald A Weikum G | 2005 | Infor- mation Retrieval2005，8，： | 1 |
| 7 | The blast and impact loading of aluminium foam显示文摘 | Merrett R P Langdon G S Theobald M D | 2013 | Materials - De- sign2013，44，： | 1 |
| 8 | Developmental reproductive toxicity of dioxins and related compounds:Cross-spe-cies comparisons显示文摘 | Peterson R E Theobald H M Kimmel G L | 1993 | Crit Rev Toxicol1993，23，： | 1 |
| 9 | Laparoscopic tubal anasto- mosis and reversal of sterilization 显示文摘 | Barjot PJ Marie G Von Theobald P | 1999 | Hum Reprod1999，14，5： | 1 |
| 10 | Numerical investigation of the response of sandwich-type panels using thin-walled tubes subject to blast loads显示文摘 | Theobald M D Nurick G N | 2007 | International of Impact Engineering2007，，34： | 1 |
| 11 | Stress sensitivity mapping for surface acoustic waves on quartz 显示文摘 | Bigler E Theobald G Hauden D | 1989 | IEEE Trans on Ultrasonics Ferroelectrics and Frequency Control1989，36，1： | 1 |
| 12 | The blast and impact loading of aluminium foam显示文摘 | MERRETT R P LANGDON G S THEOBALD M D | 2012 | Materials and Design2012，44，1： | 1 |
| 13 | TopX:efficient and versatile top-k query processing for semistructured data显示文摘 | Theobald M Bast H Majumdar D Schenkel R Weikum G | | 0，，： | 1 |
| 14 | Learning word-to-concept mappings for automatic text classification 显示文摘 | Ifrim G Theobald M and Weikum G | 2005 | ICML Workshop on Learning in Web Search2005，，： | 1 |
| 15 | The contribution of flames under ceilings to fire spread in compartments显示文摘 | Hinkley P L Wraight H G H Theobald C R | 1984 | Fire Safety Journal1984，，7： | 1 |
| 16 | Fracture of aluminum foam core sacrificial cladding subjected to air-blast loading显示文摘 | Langdon G S Karagiozova D Theobald M D | 2010 | International Journal of Impact Engineering2010，37，： | 1 |
| 17 | The contribu- tion of Names under ceilings to fire spread in compart- ments显示文摘 | Hinkley P L Wraight H G Theobald C R | 1984 | Fire Safety Journal1984，，7： | 1 |
| 18 | Numerical investigation of the response of sandwich-type panels using thin-walled tubes subject to blast loads显示文摘 | Theobald M D Nurick G N | 2007 | International of Impact Engineering2007，，34： | 1 |
| 19 | The Con- tribution of flames under ceilings to fire spread in compartments 显示文摘 | HINKLEY P L WRAIGHT H G H THEOBALD C R | 1984 | Fire safety journal1984，7，3： | 1 |
| 20 | The Contribution of flames under ceilings to fire spread in compartments显示文摘 | HINKLEY P L WRAIGHT H G H THEOBALD C R | 1984 | Fire Safety Journal1984，，7： | 1 |
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