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| 1 | Prospective validation of %p2PSA and the Prostate Health Index, in prostate cancer detection in initial prostate biopsies of Asian men, with total PSA 4-10 ng ml-1显示文摘尽管有它为屏蔽的前列腺癌症的普遍使用,低特性使 PSA 成为非最优的 biomarker,特别在 4-10 ng ml 1 的诊断灰色的地区。假积极与伴随的病态导致不必要的活体检视。这在与在 4.0 和 10 ng ml 1 之间的全部的 PSA 介绍的亚洲人是 % p2PSA 和前列腺健康索引(PHI ) 的第一未来的确认研究。我们学习了在 50 和 75 岁之间的 157 个亚洲人,与每直肠的前列腺考试的正常,经历他们的第一前列腺活体检视,用一个标准化活体检视协议,为 4-10 ng ml 1 的 PSA 层次。(19.1%) 三十被发现在活体检视上有前列腺癌症。有或没有前列腺癌症的病人之间的统计上重要的差别被作出对有利的裁决全部的 PSA, p2PSA, % p2PSA,和 PHI。在为全部的 PSA, % fPSA, % p2PSA,和 PHI 操作典型曲线的接收装置的曲线下面的区域分别地是 0.479, 0.420, 0.695,和 0.794。PHI 最好预言 prostatic 活体检视结果。在 90% 的敏感, PHI 的特性(95% CI ) 是 58.3% ,多于在 17.3% 点使全部的 PSA 的特性增加两倍,潜在地避免 77 (49%) 不必要的活体检视。类似于研究在主要白种人人口,我们有希望地证明了 % p2PSA 和 PHI 极大地超过总数并且释放总计 PSA 比率,在前列腺癌症的察觉起初活体检视。更高的 PHI 层次也对应于增加检测 GS 7 癌症的风险。我们验证了 PHI 的使用与在 4 和 10 ng ml 1 之间的浆液 PSA 在亚洲人关于前列腺活体检视帮助决策。 | Lincoln GL Tan Yung Khan Tan Bee Choo Tai Karen ML Tan Vineet Gauhar Ho Yee Tiong Robert CW Hawkins Thomas P Thamboo Felicia SK Hong Edmund Chiong | 2017 | Asian Journal of Andrology2017，19，3： | 13 |
| 2 | Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome显示文摘Background Severe acute respiratory syndrome is frequently complicated by respiratory failure requiringventilatory support.We aimed to compare the efficacy of non-invasive ventilation against invasive mechanicalventilation treating respiratory failure in this disease.Methods Retrospective analysis was conducted on all respiratory failure patients identified from the HongKong Hospital Authority Severe Acute Respiratory Syndrome Database.Intubation rate, mortality and secondaryoutcome of a hospital utilizing non-invasive ventilation under standard infection control conditions ( NIVHospital) were compared against13 hospitals using solely invasive ventilation (IMVHospitals).Multiple logisticregression analyses with adjustments for confounding variables were performed to test for association betweenoutcomes and hospital groups.Results Both hospital groups had comparable demographics and clinical profiles, but NIV Hospital (42patients) had higher lactate dehydrogenase ratio and worse radiographic score on admission and ribavirin-corticosteroid commencement.Compared to IMV Hospitals (451 patients), NIV Hospital had lower adjustedodds ratios for intubation (0.36, 95% CI 0.164 -0.791,P=0.011) and death (0.235, 95% CI 0.077 -0.716,P=0.011), and improved earlier after pulsed steroid rescue.There were no instances of transmission ofsevere acute respiratory syndrome among health care workers due to the use of non-invasive ventilation.Conclusion Compared to invasive mechanical ventilation, non-invasive ventilation as initial ventilatory supportfor acute respiratory failure in the presence of severe acute respiratory syndrome appeared to be associated withreduced intubation need and mortality. | Loretta YC Yam Alfred YF Chan Thomas MT Cheung Eva LH Tsui Jane CK Chan Vivian CW Wong | 2005 | Chinese Medical Journal2005，，17： | 3 |
| 3 | Consensus guidelines for the management of women with cervical intraepithelial neoplasia 显示文摘 | Thomas CW Thomas C Stewart M | 2003 | Am J Obstet Gynecol2003，189，： | 1 |
| 4 | Vaccine induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis 显示文摘 | RITTERSHAUS CW MILLER DP THOMAS LJ | 2000 | Arterioscler Thromb Vasc Biol2000，20，2： | 1 |
| 5 | Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis显示文摘 | Rittershaus CW Miller DP Thomas LJ | 2000 | Arteriascler Thromb Vasc Biol2000，20，9： | 1 |
| 6 | Quality of life and psychological status of patients with implantable cardioverter defibrillators显示文摘 | Thomas SA Friedmann E Kao CW | | 0，，04： | 1 |
| 7 | 2001 Consensus guidelines for the management of women with cervical intraepithelial neoplasia显示文摘 | Thomas CW Thomas C Stewart M | 2003 | Am J Obstet Gynecol2003，189，1： | 1 |
| 8 | Risk assessment of polymyositis/dermatomyositis after treatment with injectable bovine collagen implants显示文摘 | Hanke CW Thomas JA Lee WT | 1996 | J Am Acad Dermatol1996，34，3： | 1 |
| 9 | Recombinant glycoproteins that inhibit complement activation and also bind the selectin adhesion molecules显示文摘 | Ritterhaus CW Thomas LJ Miller DP | 1999 | Biol Chem1999，274，11： | 1 |
| 10 | Upper gastrointestinal tract and abdomen:Water as an orally administered contrast agent for helical CT显示文摘 | Jeffrey DA Hanhv VN | 1996 | Radiology1996，201，2： | 1 |
| 11 | Regional variation in out-ofhospital cardiac arrest incidence and outcome显示文摘 | Nichol G Thomas E Callaway CW | 2008 | JAMA2008，299，12： | 1 |
| 12 | Regional variation in out-of-hospital cardiac arrest incidence and outcome 显示文摘 | Nichol G Thomas E Callaway CW | 2008 | JAMA2008，300，12： | 1 |
| 13 | Mild traumatic brain injury in US soldiers from Iraq显示文摘 | Hoge CW Mcgurk D Thomas JL | 2008 | New Engl J Med2008，358，5： | 1 |
| 14 | Regional variation in out-of-hospital cardiac arrest incidence and outcome 显示文摘 | Nichol G Thomas E Callaway CW | 2008 | JAMA2008，300，12： | 1 |
| 15 | Regional variation in out-of-hospital cardiac arrest incidence and outcome显示文摘 | Nichol G Thomas E Callaway CW | | 0，，12： | 1 |
| 16 | Emerging thera- pies for glioblastoma显示文摘 | Thomas AA Brennan CW Deangelis LM | 2014 | JAMA Neurol2014，71，： | 1 |
| 17 | The influence ofhead size and sex on the outcome of Birmingham hip resurfacing显示文摘 | McBryde CW Theivendran K Thomas AMC | 2010 | J Bone Joint Surg(Am)2010，92，1： | 1 |
| 18 | Regional variation in out-of- hospital cardiac arrest incidence and outcome 显示文摘 | Nichol G Thomas E Callaway CW | 2008 | JAMA2008，300，12： | 1 |
| 19 | Regional variation in out - of - hospital cardiac arrest incidence and outcome 显示文摘 | Nichol G Thomas E Callaway CW | 2008 | JA- MA2008，300，12： | 1 |
| 20 | Hepatic arterial anatomy in transplantation candidates:evaluation with three-dimensional CT arteriography显示文摘 | Thomas CW Patrick CF Hanh VN | 1995 | Radiology1995，15，2： | 1 |
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