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2篇 您的检索式：作者名="Thomas Kalbe"

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		题名	作者	年代	出处	被引量
	1	No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors显示文摘Background:IgG-class autoantibodies to N-Methyl-D-Aspartate(NMDA)-type glutamate receptors define a novel entity of autoimmune encephalitis.Studies examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting results.We measured NMDA antibodies in a large,well phenotyped sample of Parkinson patients without and with cognitive impairment(n=296)and controls(n=295)free of neuropsychiatric disease.Detailed phenotyping and large numbers allowed statistically meaningful correlation of antibody status with diagnostic subgroups as well as quantitative indicators of disease severity and cognitive impairment.Methods:NMDA antibodies were analysed in the serum of patients and controls using well established validated assays.We used anti-NMDA antibody positivity as the main independent variable and correlated it with disease status and phenotypic characteristics.Results:The frequency of NMDA IgA/IgM antibodies was lower in Parkinson patients(13%)than in controls(22%)and higher than in previous studies in both groups.NMDA IgA/IgM antibodies were neither significantly associated with diagnostic subclasses of Parkinson disease according to cognitive impairment,nor with quantitative indicators of disease severity and cognitive impairment.A positive NMDA antibody status was positively correlated with age in controls but not in Parkinson patients.Conclusion:It is unlikely albeit not impossible that NMDA antibodies play a significant role in the pathogenesis or progression of Parkinson disease e.g.to Parkinson disease with dementia,while NMDA IgG antibodies define a separate disease of its own.	Franziska Hopfner Stefanie HMüller Dagmar Steppat Joanna Miller Nele Schmidt Klaus-Peter Wandinger Frank Leypoldt Daniela Berg Andre Franke Wolfgang Lieb Lukas Tittmann Monika Balzer-Geldsetzer Simon Baudrexel Richard Dodel Ruediger Hilker-Roggendorf Elke Kalbe Jan Kassubek Thomas Klockgether Inga Liepelt-Scarfone Brit Mollenhauer Petra Neuser Kathrin Reetz Oliver Riedel Claudia Schulte Jörg BSchulz Annika Spottke Alexander Storch Claudia Trenkwalder Hans-Ulrich Wittchen Karsten Witt Ullrich Wüllner Günther Deuschl Gregor Kuhlenbäumer	2019	Translational Neurodegeneration2019，8，1：	0
	2	3D Anisotropic Diffusion on GPUs by Closed-Form Local Tensor Computations显示文摘We present an efficient implementation of volumetric anisotropic image diffusion filters on modern programmable graphics processing units(GPUs),where the mathematics behind volumetric diffusion is effectively reduced to the diffusion in 2D images.We hereby avoid the computational bottleneck of a time consuming eigenvalue decomposition in R3.Instead,we use a projection of the Hessian matrix along the surface normal onto the tangent plane of the local isodensity surface and solve for the remaining two tangent space eigenvectors.We derive closed formulas to achieve this and prevent the GPU code from branching.We show that our most complex volumetric anisotropic diffusion filters gain a speed up of more than 600 compared to a CPU solution.	Arjan Kuijper Andreas Schwarzkopf Thomas Kalbe Chandrajit Bajaj Stefan Roth Michael Goesele	2013	Numerical Mathematics(Theory,Methods and Applications)2013，6，1：	0

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