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1篇 您的检索式:作者名="Thomas M.Link"
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1Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions显示文摘Cortical bone microstructure deficits may increase fracture risk in individuals with cardiovascular disease and diabetes.High resolution peripheral quantitative computed tomography(HR-pQCT)enables in vivo microstructure characterization but is limited in its ability to visualize important biological features.We conducted histological analyses and HR-pQCT imaging of distal tibia bone samples from 6 donors with cardiovascular disease(CVD)and type 2 diabetes mellitus(T2D).Histology but not HR-pQCT identified previously undocumented morphopathological deficits that may contribute to cortical bone fragility.These observations may provide guidance for improved HR-pQCT microstructural characterization as well as insight into mechanisms of cortical bone degradation.Barbara Garita Jenna Maligro Saghi Sadoughi Po Hung Wu Ellen Liebenberg Andrew Horvai Thomas M.Link Galateia J.Kazakia 2021Medicine in Novel Technology and Devices2021,,2:0
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