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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Gastrointestinal and liver disease in patients with schizophrenia:A narrative review显示文摘Schizophrenia is a severe mental illness which can have a devastating impact onan individual’s quality of life. Comorbidities are high amongst patients and lifeexpectancy is approximately 15 years less than the general population. Despite thewell-known increased mortality, little is known about the impact of gastrointestinaland liver disease on patients with schizophrenia. We aimed to reviewthe literature and to make recommendations regarding future care. Literaturesearches were performed on PubMed to identify studies related to gastrointestinaland liver disease in patients with schizophrenia. High rates of chronic liverdisease were reported, with Non-Alcoholic Fatty Liver Disease being of particularconcern;antipsychotics and metabolic syndrome were contributing factors. Ratesof acute liver failure were low but have been associated with antipsychotic useand paracetamol overdose. Coeliac disease has historically been linked to schizophrenia;however, recent research suggests that a causal link is yet to be proven.Evidence is emerging regarding the relationships between schizophrenia andpeptic ulcer disease, inflammatory bowel disease and irritable bowel syndrome;clinical vigilance regarding these conditions should be high. Patients with schizophreniapoorly engage with bowel cancer screening programmes, leading to latediagnosis and increased mortality. Clozapine induced constipation is a significantissue for many patients and requires close monitoring. There is a significantburden of gastrointestinal and liver disease amongst patients with schizophrenia.Better levels of support from all members of the medical team are essential toensure that appropriate, timely care is provided. | Rebecca K Grant William M Brindle Mhairi C Donnelly Pauline M McConville Thomas G Stroud Lorenzo Bandieri John N Plevris | 2022 | World Journal of Gastroenterology2022，28，38： | 2 |
| 3 | A fuzzy neural network approach for contractor prequalification 显示文摘 | LAM K C HU T THOMAS S N | 2001 | Journal of Construction Management and Economics2001，19，2： | 1 |
| 4 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 5 | The Guy's stone score-grading the complexity of percutaneous nephrolithotomy procedures 显示文摘 | Thomas K Smith C Hegarty N | 2011 | Urology2011，78，2： | 1 |
| 6 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 7 | Conditioning with purine analogs leads to good engraftment rates of immunodepleted grafts for aplastic anemia显示文摘 | Novitzky N Thomas V du Toit C | 2013 | Biol Blood Marrow Transplant2013，19，4： | 1 |
| 8 | 显示文摘 | Rao C N R Kulkarni G U Thomas P J | 2000 | Chem Soc Rev2000，29，1： | 1 |
| 9 | Synthetic strategies to prepare 2-alkyl,2-aryland 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines显示文摘 | Christian A G N Montalbetti Thomas S C | 2006 | Tetrahedron Letters2006，47，： | 1 |
| 10 | Changes in newcomers' psychological contracts during organizational socialization: A study of recruits entering the british army显示文摘 | Thomas H D C Anderson N | 1998 | Journal of Organizational Behavior1998，19，： | 1 |
| 11 | Evidence for downy mildew races incucumber tested in Asia,Europe,and North America显示文摘 | SHETTY N V WEHNER T C THOMAS C E D0RUCH0WSKI RW VASANTH SHETTY K P | 2002 | ScientiaHorticulturae2002，94，3： | 1 |
| 12 | Application of a hexapole collision and reaction cell in ICP-MS Part Ⅱ:Analytical figures of merit and first applications显示文摘 | FELDMANN I JAKUBOWSKI N THOMAS C | 1999 | Fresenius'' Journal of Analytical Chemistry1999，365，5： | 1 |
| 13 | Changes in newcomers' psychological contracts during organizational socialization: a study of recruits entering the British Army显示文摘 | Anderson N | 1998 | Journal of Organizational Behavior1998，19，： | 1 |
| 14 | A series of 2(Z)-2-benzylidene-6, 7-dihydroxybenzofuran-3 - ones as inhibitors of chorismate synthase 显示文摘 | THOMAS M G LAWSON C ALLANSON N M | 2003 | Bioorg Med Chem Lett2003，13，3： | 1 |
| 15 | Effects of transforming growth factor-beta on aggrecanase production and proteoglycan degradation by human chondrocytes in vitro显示文摘 | Moulharat N Lesur C Thomas M | | 0，，04： | 1 |
| 16 | Development of multiclass methods for drug residues in eggs:hydrophilic solid-phase extraction cleanup and liquid chromatography/tandem mass spectrometry analysis of tetracycline,fluorquinolone,sulfonamide,and β-lactam residues显示文摘 | HELLER D N NOCHETTO C B RUMMEL N G THOMAS M H | 2006 | J Agric Food Chem2006，54，15： | 1 |
| 17 | Allogeneic stem cell trans- plantation improves the outcome of adults with t (1;19)/E2A- PBX1 and t(4;1 I)/MLL-AF4 positive B-cell acute lymphoblastic leukemia: results of the prospective muhicenter LALA-94 study显示文摘 | Vey N Thomas X Picard C | 2006 | Leukemia2006，20，： | 1 |
| 18 | A new approach for detecting and mapping sewage impacts 显示文摘 | Costanzo S D O'Donohue M J Denniso W C Loneragan N R Thomas M | 2001 | Marine Pollution Bulletin2001，42，2： | 1 |
| 19 | Association of the metabolic syndrome with vascular disease in an older Chinese population: Guangzhou Biobank Cohort Study 显示文摘 | LAO X THOMAS G N JIANG C | 2006 | J Endocrinol Invest2006，29，： | 1 |
| 20 | The cost effectiveness of tree different measures of breast volume显示文摘 | Mary-Katherine C Thomas G Tuong N | 2006 | Aesth Plast Surg2006，30，： | 1 |
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