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| 1 | Middle cerebellar peduncles:Magnetic resonance imaging and pathophysiologic correlate显示文摘We describe common and less common diseases that can cause magnetic resonance signal abnormalities of middle cerebellar peduncles(MCP), offering a systematicapproach correlating imaging findings with clinical clues and pathologic mechanisms. Myelin abnormalities, different types of edema or neurodegenerative processes, can cause areas of abnormal T2 signal, variable enhancement, and patterns of diffusivity of MCP. Pathologies such as demyelinating disorders or certain neurodegenerative entities(e.g., multiple system atrophy or fragile X-associated tremor-ataxia syndrome) appear to have predilection for MCP. Careful evaluation of concomitant imaging findings in the brain or brainstem; and focused correlation with key clinical findings such as immunosuppression for progressive multifocal leukoencephalopahty; hypertension, post-transplant status or high dose chemotherapy for posterior reversible encephalopathy; electrolyte disorders for myelinolysis or suspected toxic-drug related encephalopathy; would yield an appropriate and accurate differential diagnosis in the majority of cases. | Humberto Morales Thomas Tomsick | 2015 | World Journal of Radiology2015，7，12： | 7 |
| 2 | 缺血性卒中或短暂性脑缺血发作患者的卒中预防指南显示文摘这份新声明旨在为缺血性卒中或短暂性脑缺血发作存活者的缺血性卒中预防提供全面和及时的循证推荐,循证推荐包括对危险因素的控制,动脉粥样硬化性疾病的干预措施,心源性栓塞的抗栓治疗以及非心源性卒中抗血小板药的应用。另外,还为其他多种特殊情况下复发性卒中的预防提供了推荐、包括动脉夹层分离、卵圆孔未闭、高同型半胱氨酸血症、高凝状态、镰状细胞病、脑静脉窦血栓形成、女性卒中(特别是与妊娠和绝经后激素替代治疗相关卒中),脑出血后肮凝药的应用,以及该指南在高危人群中执行和应用的特殊措施。 | Ralph L.Sacco Robert Adams Grge Albers Mark J.ALBERTS Oscar Benavente Karen Furie Larry B.Goldstein Philip Gorelick Jonathan Halperin Robert Harbaugh S.Claiborne Johnston Irene Katzan Margaret Kelly-Hayes Edgar J.Kenton Michael Marks Lee H.Schwamm Thomas Tomsick 曹勇军(译) 陈孝东(译) 毛成洁(译) 刘春风(译) | 2006 | 中华脑血管病论坛2006，4，1： | 3 |
| 3 | Effects of iodinated contrast on various magnetic resonance imaging sequences and field strength: Implications for characterization of hemorrhagic transformation in acute stroke therapy显示文摘AIM: To characterize the effects of iodinated contrast material(ICM) on magnetic resonance imaging(MRI) comparing different sequences and magnetic fields, with emphasis to similarities/differences with well-known signal characteristics of hemorrhage in the brain. METHODS: Aliquots of iopamidol and iodixanol mixed with normal saline were scanned at 1.5T and 3T. Signal intensity(SI) was measured using similar spin-echo(SE)-T1, SE-T2, gradient-echo(GRE) and fluid-attenuationinversion-recovery(FLAIR) sequences at both magnets. Contrast to noise ratio(CNR)(SI contrast-SI saline/SD noise) for each aliquot were calculated and Kruskall-wallis test and graphic analysis was used to compare different pulse sequences and ICMs. RESULTS: Both ICM showed increased SI on SE-T1 and decreased SI on SE-T2, GRE and FLAIR at both 1.5T and 3T, as the concentration was increased. By CNR measurements, SE-T2 had the greatest conspicuity at 3T with undiluted iopamidol(92.6 ± 0.3, P < 0.00) followed by iodixanol(77.5 ± 0.9, P < 0.00) as compared with other sequences(CNR range: 15-40). While SE-T2 had greatest conspicuity at 1.5T with iopamidol(49.3 ± 1, P < 0.01), SE-T1 showed similar or slightly better conspicuity(20.8 ± 4) than SE-T2 with iodixanol(23 ± 1.7). In all cases, hypo-intensity on GRE was less conspicuous than on SE-T2.CONCLUSION: Iodixanol and iopamidol shorten T1 and T2 relaxation times at both 1.5T and 3T. Hypo-intensity due to shortened T2 relaxation time is significantly more conspicuous than signal changes on T1-WI, FLAIR or GRE. Variations in signal conspicuity according to pulse sequence and to type of ICM are exaggerated at 3T. We postulate T2 hypointensity with less GRE conspicuity differentiates ICM from hemorrhage; given the wellknown GRE hypointensity of hemorrhage. Described signal changes may be relevant in the setting of recent intra-arterial or intravenous ICM administration in translational research and/or human stroke therapy. | Humberto Morales Lisa Lemen Ranasinghage Samaratunga Peter Nguyen Thomas Tomsick | 2016 | World Journal of Radiology2016，8，6： | 2 |
| 4 | Natural History of Perihematomal Edema in Patients With Hyperacute Spontaneous Intracerebral Hemorrhage显示文摘 | James M. Gebel Edward C. Jauch Thomas G. Brott Jane Khoury Laura Sauerbeck Shelia Salisbury Judith Spilker Thomas A. Tomsick John Duldner Joseph P. Broderick | 2002 | Stroke: Journal of the American Heart Association2002，，11： | 2 |
| 5 | Early Hemorrhage Growth in Patients With Intracerebral Hemorrhage显示文摘 | Thomas Brott Joseph Broderick Rashmi Kothari William Barsan Thomas Tomsick Laura Sauerbeck Judith Spilker John Duldner Jane Khoury | 1997 | Stroke A Journal of Cerebral Circulation1997，，1： | 1 |
| 6 | Management of 100 consecutive direct carotid-cavemous fistulas: Results of treatment withdetachable balloon显示文摘 | Lewis AI Thomas A Tomsick T | 1995 | Neurosurgery1995，36，2： | 1 |
| 7 | Early Hemorrhage Growth in Patients With Intracerebral Hemorrhage显示文摘 | Thomas Brott Joseph Broderick Rashmi Kothari William Barsan Thomas Tomsick Laura Sauerbeck Judith Spilker John Duldner Jane Khoury | 1997 | Stroke A Journal of Cerebral Circulation1997，，1： | 1 |
| 8 | Natural History of Perihematomal Edema in Patients With Hyperacute Spontaneous Intracerebral Hemorrhage显示文摘 | James M. Gebel Edward C. Jauch Thomas G. Brott Jane Khoury Laura Sauerbeck Shelia Salisbury Judith Spilker Thomas A. Tomsick John Duldner Joseph P. Broderick | 2002 | Stroke: Journal of the American Heart Association2002，，11： | 1 |
| 9 | Relative Edema Volume Is a Predictor of Outcome in Patients With Hyperacute Spontaneous Intracerebral Hemorrhage显示文摘 | James M. Gebel Edward C. Jauch Thomas G. Brott Jane Khoury Laura Sauerbeck Shelia Salisbury Judith Spilker Thomas A. Tomsick John Duldner Joseph P. Broderick | 2002 | Stroke: Journal of the American Heart Association2002，，： | 1 |
| 10 | Decreased Perihematomal Edema in Thrombolysis-Related Intracerebral Hemorrhage Compared With Spontaneous Intracerebral Hemorrhage显示文摘 | James M. Gebel Thomas G. Brott Cathy A. Sila Thomas A. Tomsick Edward Jauch Shelia Salisbury Jane Khoury Rosemary Miller Arthur Pancioli John E. Duldner Eric J. Topol Joseph P. Broderick | 2000 | Stroke: Journal of the American Heart Association2000，，3： | 1 |
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