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| 1 | Acute upper gastrointestinal bleeding in octοgenarians:Clinical outcome and factors related to mortality显示文摘AIM: To evaluate the aetiology, clinical outcome and factors related to mortality of acute upper gastrointestinal bleeding (AUGIB) in octogenarians. METHODS: We reviewed the records of all patients over 65 years old who were hospitalised with AUGIB in two hospitals from January 2006 to December of 2006. Patients were divided into two groups: Group A (65-80 years old) and Group B (> 80 years old). RESULTS: Four hundred and sixteen patients over 65 years of age were hospitalized because of AUGIB. Group A included 269 patients and Group B 147 patients. Co-morbidity was more common in octogenarians (P = 0.04). The main cause of bleeding was peptic ulcer in both groups. Rebleeding and emergency surgery were uncommon in octogenarians and not different from those in younger patients. In-hospital complications were more common in octogenarians (P = 0.05) and more patients died in the group of octogenarians compared to the younger age group (P = 0.02). Inability to perform endoscopic examination (P = 0.002), presence of high risk for rebleeding stigmata (P = 0.004), urea on admission (P = 0.036), rebleeding (P = 0.004) and presenceof severe co-morbidity (P < 0.0001) were related to mortality. In multivariate analysis, only the presence of severe co-morbidity was independently related to mortality (P = 0.032). CONCLUSION: While rebleeding and emergency surgery rates are relatively low in octogenarians with AUGIB, the presence of severe co-morbidity is the main factor of adverse outcome. | George J Theocharis Vassiliki Arvaniti Stelios F Assimakopoulos Konstantinos C Thomopoulos Vassilis Xourgias Irini Mylonakou Vassiliki N Nikolopoulou | 2008 | World Journal of Gastroenterology2008，14，25： | 15 |
| 2 | Acute upper gastrointestinal bleeding in patients on long-term oral anticoagulation therapy: Endoscopic findings, clinical management and outcome显示文摘AIM: Acute gastrointestinal bleeding is a severe complication in patients receiving long-term oral anticoagulant therapy.The purpose of this study was to describe the causes and clinical outcome of these patients.METHODS: From January 1999 to October 2003, 111patients with acute upper gastrointestinal bleeding (AUGIB)were hospitalized while on oral anticoagulants. The causes and clinical outcome of these patients were compared with those of 604 patients hospitalized during 2000-2001with AUGIB who were not taking warfarin.RESULTS: The most common cause of bleeding was peptic ulcer in 51 patients (45%) receiving anticoagulants compared to 359/604 (59.4%) patients not receiving warfarin (P<0.05). No identifiable source of bleeding could be found in 33 patients (29.7%) compared to 31/604(5.1%) patients not receiving anticoagulants (P= 0.0001).The majority of patients with concurrent use of non-steroidal anti-inflammatory drugs (NSATDs) (26/35, 74.3%) had a peptic ulcer as a cause of bleeding while 32/76 (40.8%)patients not taking a great dose of NSATDs had a negative upper and lower gastrointestinal endoscopy. Endoscopic hemostasis was applied and no complication was reported.Six patients (5.4%) were operated due to continuing or recurrent hemorrhage, compared to 23/604 (3.8%) patients not receiving anticoagulants. Four patients died, the overall mortality was 3.6% in patients with AUGIB due to anticoagulants, which was not different from that in patients not receiving anticoagulant therapy.CONCLUSION: Patients with AUGIB while on long-term anticoagulant therapy had a clinical outcome, which is not different from that of patients not taking anticoagulants.Early endoscopy is important for the management of these patients and endoscopic hemostasis can be safely applied. | Konstantinos C Thomopoulos Konstantinos P Mimidis George J Theocharis Anthie G Gatopoulou Georgios N Kartalis Vassiliki N Nikolopoulou | 2005 | World Journal of Gastroenterology2005，11，9： | 5 |
| 3 | Port site recurrences after laparoscopic surgery显示文摘 | Schaeff B Paolucci V Thomopoulos J | 1998 | Dig Surg1998，15，： | 1 |
| 4 | Port site recurrences after laparoscopic surgery显示文摘 | Schaeff B Paolucci V Thomopoulos J | 1998 | Dig Surg1998，15，2： | 1 |
| 5 | An herative Solution to the Inverse Kinematics of Robotic Manipulators显示文摘 | Thomopoulos S C A TAM R Y J | 1991 | Mechanism and Machine Theory1991，26，4： | 1 |
| 6 | Port site reCarrences after laparoscopic surgery显示文摘 | SCHAEFF B PAOLUCCI V THOMOPOULOS J | 1998 | A review Dig-Surg1998，15，2： | 1 |
| 7 | Port site recurrences after laparoscopic surgery 显示文摘 | Schaeff B Paolucci V Thomopoulos J | 1998 | Dig Surg1998，15，2： | 1 |
| 8 | Effect of several growth factors on canine flexor tendon fibroblast proliferation and collagen synthesis in vitro显示文摘 | Thomopoulos S Harwood F L Silva M J | 2005 | J Hand Surg Am2005，30，3： | 1 |
| 9 | Rotator cuff defect healing:a biomechanical and histologic analysis in an animal model显示文摘 | Carpenter J E Thomopoulos S Flanagan CL | 1998 | J Shoulder Elbow Surg1998，7，： | 1 |
| 10 | Port site recurrences after laparoscopic surgery显示文摘 | Schaeff B Paolucci V Thomopoulos J | 1998 | A review Dig-Surg1998，15，2： | 1 |
| 11 | Animal models of tendon and ligament injuries for tissue engineering applications 显示文摘 | CARPENTER J E THOMOPOULOS S SOSLOWSKY L J | 1999 | Clin Orthop Relat Res1999，，： | 1 |
| 12 | Liver steatosis is an independent risk factor for treatment failure in patients with chronic hepatitis C显示文摘 | THOMOPOULOS K C THEOCHARIS G J TSAMANTAS A C | 2005 | Eur J Gastroenterol Hepatol2005，17，： | 1 |
| 13 | Effect of bone morpho- genetic protein 2 on tendon-to-bone healing in a canine flexor ten- don model显示文摘 | Thomopoulos S Kim HM Silva M J | 2012 | J Orthop Res2012，30，11： | 1 |
| 14 | Port site recurrences after laparoscopic surgery显示文摘 | Sochaeff B Paolucci V Thomopoulos J | 1998 | Dig Surg1998，15，2： | 1 |
| 15 | Tendon to bone healing: differences in biomechanical, structural, and compositional properties due to a range of activity levels显示文摘 | THOMOPOULOS S WILLIAMS G R SOSLOWSKY L J | 2003 | J Bi- omech Eng2003，25，1： | 1 |
| 16 | Port site recurrences after laparoscopic surgery显示文摘 | Sochaeff B Paolucci V Thomopoulos J | 1998 | Dig Surg1998，15，2： | 1 |
| 17 | Post site recurrences afterlaparoscopic surgery 显示文摘 | Sochaeff B Paolucci V Thomopoulos J | 1998 | Dig Surg1998，15，2： | 1 |
| 18 | Port site recurrences after laparoscopic surgery显示文摘 | Schaeff B Paolucci V Thomopoulos J | 1998 | Dig Surg1998，15，6： | 1 |
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