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| 1 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 2 | Gynecologic oncologists involvement on ovarian cancer standard of care receipt and survival显示文摘AIM:To examine the influence of gynecologic oncolo-gists(GO) in the United States on surgical/chemotherapeutic standard of care(SOC), and how this translates into improved survival among women with ovarian cancer(OC).METHODS: Surveillance, Epidemiology, and End Result(SEER)-Medicare data were used to identify 11688 OC patients(1992-2006). Only Medicare recipients with an initial surgical procedure code(n = 6714) were included. Physician specialty was identified by linking SEER-Medicare to the American Medical Association Masterfile. SOC was defined by a panel of GOs. Multivariate logistic regression was used to determine predictors of receiving surgical/chemotherapeutic SOCand proportional hazards modeling to estimate the effect of SOC treatment and physician specialty on survival. RESULTS: About 34% received surgery from a GO and 25% received the overall SOC. One-third of women had a GO involved sometime during their care. Women receiving surgery from a GO vs non-GO had 2.35 times the odds of receiving the surgical SOC and 1.25 times the odds of receiving chemotherapeutic SOC(P < 0.01). Risk of mortality was greater among women not receiving surgical SOC compared to those who did [hazard ratio = 1.22(95%CI: 1.12-1.33), P < 0.01], and also was higher among women seen by non-GOs vs GOs(for surgical treatment) after adjusting for covariates. Median survival time was 14 mo longer for women receiving combined SOC. CONCLUSION: A survival advantage associated with receiving surgical SOC and overall treatment by a GO is supported. Persistent survival differences, particularly among those not receiving the SOC, require further investigation. | Sun Hee Rim Shawn Hirsch Cheryll C Thomas Wendy R Brewster Darryl Cooney Trevor D Thompson Sherri L Stewart | 2016 | World Journal of Obstetrics and Gynecology2016，5，2： | 3 |
| 3 | No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer显示文摘AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene. | Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah J Plummer Thomas C Tucker Graham Case Li Li | 2009 | World Journal of Gastroenterology2009，15，30： | 2 |
| 4 | J Am Chem Soc显示文摘 | Justin Thomas K R Thompson Alexis L Sivakumar Aathimanikandan V Bardeen hristopher J and Thayumanava S | 2005 | 127:373-3832005，127，： | 1 |
| 5 | Gastric emptying as a determinant of the oral glucose tolerance test显示文摘 | Thompson D G Wingate D L Thomas M | 1982 | Gastroenterology1982，82，1： | 1 |
| 6 | Sexual dysfuction and antidepressant 1显示文摘 | Segraves R T Thompson T L Thomas W | 1996 | C1 in Psychiatry 1996:57(12):Suppl 1-121996，，： | 1 |
| 7 | Fertigation frequency for subsurface drip-irrigated Broccoli显示文摘 | Thompson Thomas L Scott A White James Walworth | 2003 | Soil Sci Soc Am J2003，67，： | 1 |
| 8 | PPARγ-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma 显示文摘 | CHAFFER C L THOMAS D M THOMPSON E W | 2006 | BMC Cancer2006，6，3： | 1 |
| 9 | Soil hydraulic properties affecting discharge uniformity of gravity-fed subsurface drip irrigation systems 显示文摘 | Lazarovitch N Shani U Thompson Thomas L | 2006 | ASCE Journal of Irrigation and Drainage Engineering2006，132，6： | 1 |
| 10 | PPAR γ -independent induction of growth arrest and apoptosis in prostate and bladder carcinoma显示文摘 | Chaffer C L Thomas D M Thompson E W | 2006 | BMC Cancer2006，6，53： | 1 |
| 11 | Soil hydraulic properties affecting discharge uniformity of gravity-fed subsurface drip irrigation systems显示文摘 | Lazarovitch N Shani U Thompson Thomas L | 2006 | ASCE Journal of Irrigation and Drainage Engineering2006，132，6： | 1 |
| 12 | Feitigation frequency for subsurface drip-irrigated brolloli 显示文摘 | Thomas L Thompson Scott A white James Walworth | 2003 | Soil science Society of America journal2003，67，3： | 1 |
| 13 | Age-related decline in actomyosin function显示文摘 | Prochniewicz E Thomas D D Thompson L V | | 0，，60： | 1 |
| 14 | Modifying chrysanthemum (Dendranthema grandiglorum) growth habit genetic manipu-lation显示文摘 | Petty L M Thompson A J Thomas B 2000 | 2000 | Acta Hort2000，508，： | 1 |
| 15 | PPAR-γ-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma显示文摘 | CHAFFER C L THOMAS D M THOMPSON E W | 2006 | BMC Cancer2006，6，： | 1 |
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