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| 1 | Sodium alendronate loaded poly(L-lactideco-glycolide)microparticles immobilized on ceramic scaffolds for local treatment of bone defects显示文摘Bone tissue regeneration in critical-size defects is possible after implantation of a 3D scaffold and can be additionally enhanced once the scaffold is enriched with drugs or other factors supporting bone remodelling and healing.Sodium alendronate(Aln),a widely used anti-osteoporosis drug,exhibits strong inhibitory effect on bone resorption performed by osteoclasts.Thus,we propose a new approach for the treatment of bone defects in craniofacial region combining biocompatible titanium dioxide scaffolds and poly(L-lactide-co-glycolide)microparticles(MPs)loaded with Aln.The MPs were effectively attached to the surface of the scaffolds’pore walls by human recombinant collagen.Drug release from the scaffolds was characterized by initial burst(2466% of the drug released within first 24 h)followed by a sustained release phase(on average 5 mg of Aln released per day from Day 3 to Day 18).In vitro tests evidenced that Aln at concentrations of 5 and 2.5 mg/ml was not cytotoxic for MG-63 osteoblast-like cells(viability between 8166% and 9863% of control),but it prevented RANKL-induced formation of osteoclast-like cells from macrophages derived from peripheral blood mononuclear cells,as shown by reduced fusion capability and decreased tartrateresistant acid phosphatase 5b activity(5665% reduction in comparison to control after 8 days of culture).Results show that it is feasible to design the scaffolds providing required doses of Aln inhibiting osteoclastogenesis,reducing osteoclast activity,but not affecting osteoblast functions,which may be beneficial in the treatment of critical-size bone tissue defects. | Lucja Rumian Cornelia Wolf-Brandstetter Sina Roβler Katarzyna Reczynska Hanna Tiainen Havard J.Haugen Dieter Scharnweber Elzbieta Pamula | 2020 | Regenerative Biomaterials2020，7，3： | 5 |
| 2 | Genetic effects in common on maximal walking speed and muscle performance in older women显示文摘 | Tiainen K Pajala S Sipila S | 2007 | Scand J Med Sci Sports2007，17，3： | 1 |
| 3 | Plasmid purification using non-porous anian-exchange silica fibres 显示文摘 | Tiainen P Gustavsson P E Mansson M O | 2007 | J Chromatogr A2007，1149，2： | 1 |
| 4 | Stress relaxation behavior in bending of high strength copper alloys in the Cu-Ni-Sn system显示文摘 | VIRTANEN P TIAINEN T | 1997 | Mater Sci Eng A1997，238，： | 1 |
| 5 | Amorphous Carbon as a Bio-Mechanical Coat- ing-Mechanical Properties and Biological Applications显示文摘 | Tiainen VM | 2001 | Diamond Relat Mater2001，10，： | 1 |
| 6 | Precipitation at faceting grain boundaries of Cu-Ni-Sn alloys显示文摘 | Virtanen P Tiainen T | 1998 | Mater Sci Eng1998，251，： | 1 |
| 7 | Growth suppression by Lkb1 is mediated by a G ( 1 ) cell cycle arrest 显示文摘 | Tiainen M Ylikorkala A Makela TP | 1999 | Proc Natl Acad Sci USA1999，96，16： | 1 |
| 8 | Therapeutic hypothermia after out-of-hospital cardiac arrest in Finnish intensive care units: the FINNRESUSCI study 显示文摘 | Vaahersalo J Hiltunen P Tiainen M | 2013 | Inten- sive Care Med2013，39，5： | 1 |
| 9 | Amorphous carbon as a bio-mechanical coating--mechanical properties and biological applications 显示文摘 | Tiainen V M | 2001 | Diamond and Related Materials2001，10，： | 1 |
| 10 | Serum neuron-specific enolase and S-100B protein in cardiac arrest patients treated with hy pothermia显示文摘 | Tiainen M Roine RO Pettila V | 2003 | Stroke2003，34，12： | 1 |
| 11 | Enhanced invitro osteoblast differentiation on Ti02 scaffold coated with alginatehydrogel containing simvastatin 显示文摘 | PULLISAAR H TIAINEN H LANDIN M A | 2013 | J Tissue Eng2013，4，20： | 1 |
| 12 | Growth arrest by the LKB1 tumor suppressor:induction of p21 (WAF1/CIP1) 显示文摘 | Tiainen M Vaahtomeri K Ylikorkala A | 2002 | Hum Mol Genet2002，11，13： | 1 |
| 13 | Growth suppression by Lkb1 is mediated by a G(1)cell cycle arrest显示文摘 | Tiainen M Ylikorkala A Makela TP | 1999 | Proc Natl Acad Sci USA1999，96，16： | 1 |
| 14 | Predictive power of serum NSE and OHCA score regarding 6-month neurologic outcome after out-of-hospital ventricular fibrillation and therapeutic hypothermia显示文摘 | Oksanen T Tiainen M Skrifvars MB | | 0，，02： | 1 |
| 15 | Associations between inflam- matory markers, candidate polymorphisms and physic'al performance in older Danish twins显示文摘 | Tiainen K Thinggam-d M Jylh M | 2012 | Exp Gerontol2012，47，1： | 1 |
| 16 | Processing of highly porous TiO2 bone scaffolds with improved compressive strength 显示文摘 | Tiainen H Wiedmer D Haugen HJ | 2013 | J Eur Ceram Soc2013，33，1： | 1 |
| 17 | Predictive power of serum NSE and OHCA score regarding 6 - month neurologie outcome after out - of - hospital ventricular fibrillation and therapeutic hypothermia 显示文摘 | Oksanen T Tiainen M Skrifvars MB | 2009 | Resuscitation2009，80，2： | 1 |
| 18 | Growth arrest by the LKB1 tumor suppressor: induction of p21 (WAF1/ CIP1 ) 显示文摘 | Tiainen M Vaahtomeri K Ylikorkala A | 2002 | Hum Mol Genet2002，11，13： | 1 |
| 19 | Disordered glycometabolism involved in pathogenesis of Kashin-Beck disease, an endemic osteoarthritis in China显示文摘 | Wu C Lei R Tiainen M | 2014 | Exp Cell Res2014，326，2： | 1 |
| 20 | Growth ar- rest by the LKB1 tumor suppressor: induction of p21 (WAF1/CIP1) 显示文摘 | Tiainen M Vaahtomeri K Ylikorkala A | 2002 | Hum Mol Genet2002，11，13： | 1 |
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