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| 1 | Beyond tumorigenesis: cancer stem cells in metastasis显示文摘在肿瘤开始的癌症干细胞(CSC ) 的重要性坚定地在白血病被建立了并且最近为许多稳固的肿瘤报导了。然而,特别地关于转移,在多级式的癌症前进的 CSC 的角色有不定义 beenwell。癌症转移要求在远机关播种和 specializedCSCs 的成功的殖民。正常干细胞和 CSC 的生物学分享显著类似并且当适用于癌症的学习时,可以有重要含意转移。而且,重叠分子和小径的集合最近被识别了调整干细胞移植和癌症转移。这些分子组成两个都为移植 CSC 由主要肿瘤和养育的机关微型环境的形成便于转移前壁龛的开始的细胞的相互作用的一个复杂网络。在这评论,我们在这个动态领域里调查了最近的进展并且建议 CSC 在 tumorigenesis 和转移在假定一个中央角色的癌症前进的一个统一模型。更好作为变形串联的一个基本部件理解 ofCSCs 将对变形癌症导致新奇治疗学的策略。 | Feng Li Benjamin Tiede Joan Massague Yibin Kang | 2007 | Cell Research2007，17，1： | 85 |
| 2 | From milk to malignancy: the role of mammary stem cells in development, pregnancy and breast cancer显示文摘乳腺(MaSCs ) 的成年干细胞是在怀孕期间在发身和它的扩大期间为腺的产生负责的房间的一张高度有活力的人口。在最近的年里,重要进展在理解这些房间怎么在人并且在鼠标在这些发展地重要的进程期间被调整被做了。理解 MaSCs 怎么被调整正在成为研究的一个特别地重要的区域,给那他们可以是为在乳癌的转变的特别地易受影响的目标。这里,我们总结 MaSCs 的鉴定,他们怎么被调整并且为他们用作乳癌的起源的证据。特别地,我们集中在 MaSC 人口的变化怎么可以向两个解释立即在怀孕以后得好攻击的 ER/PR (?) 乳癌的增加的风险和得 ER/PR (+) 肿瘤的长期的减少的风险。 | Benjamin Tiede Yibin Kang | 2011 | Cell Research2011，21，2： | 8 |
| 3 | Fuel optimal low thrust rendezvous with outer planets via gravity assist显示文摘Low thrust propulsion and gravity assist (GA) are among the most promising techniques for deep space explorations.In this paper the two techniques are combined and treated comprehensively,both on modeling and numerical techniques.Fuel optimal orbit rendezvous via multiple GA is first formulated as optimal guidance with multiple interior constraints and then the optimal necessary conditions,various transversality conditions and stationary conditions are derived by Pontryagin's Maximum Principle (PMP).Finally the initial orbit rendezvous problem is transformed into a multiple point boundary value problem (MPBVP).Homotopic technique combined with random searching globally and Particle Swarm Optimization (PSO),is adopted to handle the numerical difficulty in solving the above MPBVP by single shooting method.Two scenarios in the end show the merits of the present approach. | GUO TieDing JIANG FangHua BAOYIN HeXi LI JunFeng | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，4： | 8 |
| 4 | Application of nanoparticle tracking analysis for characterising the fate of engineered nanoparticles in sediment-water systems显示文摘Novel applications of nanotechnology may lead to the release of engineered nanoparticles(ENPs), which result in concerns over their potential environmental hazardous impact. It is essential for the research workers to be able to quantitatively characterise ENPs in the environment and subsequently to assist the risk assessment of the ENPs. This study hence explored the application of nanoparticle tracking system(NTA) to quantitatively describe the behaviour of the ENPs in natural sediment-water systems. The NTA allows the measurement of both particle number concentration(PNC) and particle size distribution(PSD) of the ENPs. The developed NTA method was applied to a range of gold and magnetite ENPs with a selection of surface properties. The results showed that the positively-charged ENPs interacted more strongly with the sediment than neutral and negatively-charged ENPs. It was also found that the citrate coated Au ENPs had a higher distribution percentage(53%) than 11-mercaptoundecanoic acid coated Au ENPs(20%) and citrate coated magnetite ENPs(21%). The principles of the electrostatic interactions between hard(and soft) acids and bases(HSAB) are used to explain such behaviours; the hard base coating(i.e. citrate ions) will interact more strongly with hard acid(i.e. magnetite) than soft acid(i.e. gold).The results indicate that NTA is a complementary method to existing approaches to characterise the fate and behaviour of ENPs in natural sediment. | Ping Luo Alejandro Roca Karen Tiede Katie Privett Jiachao Jiang John Pinkstone Guibin Ma Jonathan Veinot Alisatair Boxall | 2018 | Journal of Environmental Sciences2018，30，2： | 6 |
| 5 | Heterotopic bone formation in the musculus latissimus dorsi of sheep usingβ-tricalcium phosphate scaffolds:evaluation of different seeding techniques显示文摘Osseous reconstruction of large bone defects remains a challenge in oral and maxillofacial surgery.In addition to autogenous bone grafts,which despite potential donor-site mobility still represent the gold standard in reconstructive surgery,many studies have investigated less invasive alternatives such as in vitro cultivation techniques.This study compared different types of seeding techniques on pureβ-tricalcium phosphate scaffolds in terms of bone formation and ceramic resorption in vivo.Cylindrical scaffolds loaded with autologous cancellous bone,venous blood,bone marrow aspirate concentrate or extracorporeal in vitro cultivated bone marrow stromal cells were cultured in sheep on a perforator vessel of the musculus latissimus dorsi over a 6-month period.Histological and histomorphometric analyses revealed that scaffolds loaded with cancellous bone were superior at promoting heterotopic bone formation and ceramic degradation,with autogenous bone and bone marrow aspirate concentrate inducing in vivo formation of vital bone tissue.These results confirm that autologous bone constitutes the preferred source of osteoinductive and osteogenic material that can reliably induce heterotopic bone formation in vivo. | Simon Spalthoff Rudiger Zimmerer Jan Dittmann Horst Kokemuller Marco Tiede Laura Flohr Philippe Korn Nils-Claudius Gellrich Philipp Jehn | 2018 | Regenerative Biomaterials2018，5，2： | 3 |
| 6 | Big Earth data:disruptive changes in Earth observation data management and analysis?显示文摘Turning Earth observation(EO)data consistently and systematically into valuable global information layers is an ongoing challenge for the EO community.Recently,the term‘big Earth data’emerged to describe massive EO datasets that confronts analysts and their traditional workflows with a range of challenges.We argue that the altered circumstances must be actively intercepted by an evolution of EO to revolutionise their application in various domains.The disruptive element is that analysts and end-users increasingly rely on Web-based workflows.In this contribution we study selected systems and portals,put them in the context of challenges and opportunities and highlight selected shortcomings and possible future developments that we consider relevant for the imminent uptake of big Earth data. | Martin Sudmanns Dirk Tiede Stefan Lang Helena Bergstedt Georg Trosta Hannah Augustin Andrea Baraldi Thomas Blaschke | 2020 | International Journal of Digital Earth2020，13，7： | 3 |
| 7 | CD8alpha + beta (low) effector T cells in systemic lupus erythematosus显示文摘 | WERWITZKE S TIEDE A JACOBS R | 2008 | Scand J Immunol2008，67，5： | 1 |
| 8 | Leuwer,volume cutting for virtual petrous bone surgery显示文摘 | Plfesser B Petersik A Tiede U | | 0，，02： | 1 |
| 9 | Immunophenotyping of the human bulge region:the questto define useful in situ markers for human epithelial hairfollicle stem cells and their niche显示文摘 | Kloepper JE Tiede S Brinckmann J | | 0，，07： | 1 |
| 10 | Shaping Nanometer-scale Architecture Through Surface Chemistry 显示文摘 | SAPONJIC Z V DIMITRIJEVIC N M TIEDE D M | 2005 | Adv Mater2005，17，： | 1 |
| 11 | Endocrine controls of primary adult human stem cell biology: thyroid hormones stirmdate keratin 15 expres- sion, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro显示文摘 | Tiede S Bohm K Meier N | 2010 | Eur J Biol2010，89，0： | 1 |
| 12 | Hair follicle stem cells: walking the maze 显示文摘 | Tiede S Kloepper JE Bodo E | 2007 | Eur J Cell Biol2007，86，7： | 1 |
| 13 | Pigs transgenic for human thrombomodulin have elevated production of activated protein C显示文摘 | Petersen B Ramackers W Tiede A | 2009 | Xenotransplantation2009，16，： | 1 |
| 14 | The 'follicular troehanter': an epithelial compartment of the human hair follicle bulge region in need of further characterization 显示文摘 | Tiede S Kloepper JE Whiting DA | 2007 | Br J Dermatol2007，157，5： | 1 |
| 15 | Segmentation of the Visible Human for High-quality Volume-based Visualization显示文摘 | Thomas Schiemann Ulf Tiede Karl Heinz Hohne | 1997 | Medical Image Analysis1997，1，4： | 1 |
| 16 | Segmentation of the visible human for high quality volume-based visualization 显示文摘 | Schiemann T Tiede U Hohne K H | 1997 | Medical Image Analysis (S 1361-8415)1997，1，4： | 1 |
| 17 | Modern management of prosthetic valve anticoagulation显示文摘 | Tiede DJ Nishimura RA Gastineau DA | | 0，，： | 1 |
| 18 | Metamemory judgments and thebenefits of repeated study : Improving recall predictionsthrough the activation of appropriate knowledge 显示文摘 | Tiede H L Leboe J P | 2009 | Jour-nal of Experimental Psychology : Learning Memory andCognition2009，35，3： | 1 |
| 19 | Characterization of nanomaterials in food by electron microscopy 显示文摘 | Dudkiewicz A Tiede K BoxaU A | 2011 | TrAC Trends in Analytical Chemistry2011，30，1： | 1 |
| 20 | Investigation of medical 3D-rendering algorithms显示文摘 | Tiede U Heinz K | 1990 | IEEE Computer Graphics & Application1990，10，2： | 1 |
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