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| 1 | Current status of laparoscopic and robotic ventral mesh rectopexy for external and internal rectal prolapse显示文摘External and internal rectal prolapse with their affiliated rectocele and enterocele, are associated with debilitating symptoms such as obstructed defecation, pelvic pain and faecal incontinence. Since perineal procedures are associated with a higher recurrence rate, an abdominal approach is commonly preferred. Despite the description of greater than three hundred different procedures, thus far no clear superiority of one surgical technique has been demonstrated. Ventral mesh rectopexy(VMR) is a relatively new and promising technique to correct rectal prolapse. In contrast to the abdominal procedures of past decades, VMR avoids posterolateral rectal mobilisation and thereby minimizes the risk of postoperative constipation. Because of a perceived acceptable recurrence rate, good functional results and low mesh-related morbidity in the short to medium term, VMR has been popularized in the past decade. Laparoscopic or robotic-assisted VMR is now being progressively performed internationally and several articles and guidelines propose the procedure as the treatment of choice for rectal prolapse. In this article, an outline of the current status of laparoscopic and robotic ventral mesh rectopexy for the treatment of internal and external rectal prolapse is presented. | Jan J van Iersel Tim JC Paulides Paul M Verheijen John W Lumley Ivo AMJ Broeders Esther CJ Consten | 2016 | World Journal of Gastroenterology2016,22,21: | 20 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013,19,48: | 4 |
| 3 | Biochar and the Nitrogen Cycle: Introduction显示文摘 | Clough Tim J Condron Leo M | 2010 | Journal of Environmental Quality2010,,4: | 2 |
| 4 | Evolution of volatile aldehydes in Iberian ham matured under different processing conditions显示文摘 | Martín L Timón M L Petrón M J | | 0,,04: | 1 |
| 5 | Biochar and the nitrogen cycle:Introduction显示文摘 | Tim J C Leo M C | 2010 | Journal of Environmental Quality2010,39,4: | 1 |
| 6 | Assessment of sediment and porewater after one year of sub aqueous capping of contaminated sediments in Hamilton Harbour, Canada显示文摘 | Azcue J M Zeman A J Alena Mudroch Fernando Rosa Tim Patterson | 1998 | Wat Sci Tech1998,37,67: | 1 |
| 7 | Biochar Incorporation into Pasture Soil Suppresses in situ Nitrous Oxide Emissions from Ruminant Urine Patches显示文摘 | Taghizadeh-Toosi Arezoo Clough Tim J Condron Leo M Sherlock Robert R Anderson Craig R Craigie Robin A | 2011 | EN2011,,2: | 1 |
| 8 | Morphological differences in BMP-2-induced ectopic bone between solid and crushed hyaluronan hydrogel templates显示文摘 | Gry Hulsart-Billstr?m Sonya Piskounova Lars Gedda Britt-Marie Andersson Kristoffer Bergman J?ns Hilborn Sune Larsson Tim Bowden | 2013 | Journal of Materials Science: Materials in Medicine2013,,5: | 1 |
| 9 | Structured light scanning for high-resolution documentation of in situ archaeological finds显示文摘 | SHANNON P M TIM G JEAN J H | 2009 | Journal of Archaeological Science2009,36,1: | 1 |
| 10 | Chitosan-alginate microcap- sules for oral delivery of egg yolk immunoglobulin (IgY) 显示文摘 | LI X Y JIN L J TIM A M | 2007 | J Agric Food Chem2007,55,8: | 1 |
| 11 | Unconventional shale gas systems:The Mississippian barnett shale of north central Texas as one model for thermogenic shale gas assessment显示文摘 | Jarvie M Ronald J H Tim E R | 2007 | AAPG Bulletin2007,91,4: | 1 |
| 12 | Establishing a standard definition for child overweight and obesity worldwide: international survey显示文摘 | Tim J Cole Mary C Beltizzi Katherine M Flegal | 2000 | BM J2000,320,: | 1 |
| 13 | Unconventional shale- gas systems:The Mississippian Barnett Shale of north-central Texas as one model for thermogenic shale-gas assessment显示文摘 | Daniel M J Ronald J H Tim E R et a/ | 2008 | AAPG Bulletin2008,92,8: | 1 |
| 14 | Candidate High Spectral Resolution Infrared Indices for Crop Cover 显示文摘 | Tim J M Bruno A Mark D F | 1993 | Remote Sens Environ1993,46,1: | 1 |
| 15 | The role of total hip replacement in the treatment of displaced intracapsular hip fractures in the elderly显示文摘 | Tim J Chesser S Vijaya M | 2012 | Inju- ry2012,43,10: | 1 |
| 16 | Unconventional shale- gas systems:The Mississlppian Barnett Shale of north-central Texas as one model for thermogenic shale-gas assessment显示文摘 | Daniel M J Ronald J H Tim E R | 2008 | AAPG Bulletin2008,92,8: | 1 |
| 17 | Market Influence on the Low Carbon Energy Refurbishment of Existing Multi - residential Buildings 显示文摘 | Jonathan G B A Tim J Elizabeth M S | 2009 | Energy Policy2009,,37: | 1 |
| 18 | Influence of moisture con- tent and temperature on methane adsorption isotherm analy- sis for coals from a low-rank,biogenically sourced gas reser- voir显示文摘 | Peter J C Tim A M Tennille E M | 2008 | International Journal of Coal Geology2008,76,1: | 1 |
| 19 | Plant sterols:Friend or foe in CNS disorders? 显示文摘 | Tim V Jeroen F J Jo M | 2015 | Progress Lipid Research2015,58,: | 1 |
| 20 | Biochar Incorporation into Pasture Soil Suppresses in situ Nitrous Oxide Emissions from Ruminant Urine Patches显示文摘 | Taghizadeh-Toosi Arezoo Clough Tim J Condron Leo M Sherlock Robert R Anderson Craig R Craigie Robin A | 2011 | EN2011,,2: | 1 |