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1篇 您的检索式:作者名="Timothy Humpton"
    题名 作者 年代 出处 被引量
1Taking up the reins of power:metabolic functions of p53显示文摘The clear importance of p53 as a tumour suppressor protein has propelled decades of in tense research focused on understanding the functions of p53 and attempting to harness this knowledge for patient benefit.p53 plays a pivotal role in the ability of cells to sense and respond to stress-functions that contribute not only to limitation of cancer development,but also to modulating numerous other aspects of health and disease.Although the can on ical activities of p53 relate to the elimination of damaged cells through cell death or senescenee,more recent work has highlighted a role for p53 as a guardian of cell survival and facilitator of adaptation during metabolic stress.These emerging metabolic features of p53 activity are proving to be crucial for many of its essential functions.Timothy Humpton Karen H.Vousden 2019Journal of Molecular Cell Biology2019,11,7:0
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