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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | Tourism growth, national development and regional inequality in Turkey 显示文摘 | Tosun C Timothy D J Ozturk Y | 2003 | Journal of Sustainable Tourism2003，11，23： | 1 |
| 3 | Tourism and reconciliation between Mainland China and Taiwan 显示文摘 | Guo Y Kim S S Timothy D J | 2006 | Tourism Management2006，27，5： | 1 |
| 4 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 5 | Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products 显示文摘 | Egil L Timothy J S Atsutoshi Y | 1999 | J Biol Chem1999，274，33： | 1 |
| 6 | Tourism Growth National Develop- ment and Regional Inequality in Turkey显示文摘 | Tosun C Timothy D J Qzturk Y | 2013 | Journal of Sustainable Tourism2013，11，2： | 1 |
| 7 | Tourism growth, national development and regional inequa -lityin Turkey显示文摘 | Tosun C Timothy D J Ozturk Y | 2003 | Journal of Sustainable Tourism2003，11，2： | 1 |
| 8 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 9 | Tourism growth, national development and regional inequality in Turkey显示文摘 | Tosun C Timothy D J Ozturk Y | 2003 | Journal of Sustainable Tourism2003，5，2： | 1 |
| 10 | Tourism and re2 conciliation between Mainland China and Taiwan 显示文摘 | GUO Y Z KIM S S TIMOTHY D J | 2006 | Tourism Management2006，，27： | 1 |
| 11 | Tourism growth, national development and regional inequality in Turkey 显示文摘 | Tosum C Timothy D J Ozturk Y | 2003 | Journal of Sus -tainable Tourism2003，5，2： | 1 |
| 12 | Oxygen Vacancies and Ferromagnetism in Co,Til- x02-x-y 显示文摘 | JAFFE J E TIMOTHY C DROUBA Y | 2005 | Journal of Appl Phys2005，97，： | 1 |
| 13 | Tourism Growth, National Development andRegional Inequality in Turkey 显示文摘 | Tosun C Timothy D J Ozturk Y | 2003 | Journal of Sustainable Tourism2003，11，2： | 1 |
| 14 | Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products显示文摘 | EGIL L TIMOTHY J S ATSUTOSHI Y | 1999 | J Biol Chem1999，274，33： | 1 |
| 15 | Tourism Growth,National Development and Regional Inequality in Turkey显示文摘 | Tosun C Timothy D J Ozturk Y | 2003 | Journal of Sustainable Tourism2003，11，2： | 1 |
| 16 | Tourism Growth, Nation- al Development and Regional Inequality in Turkey 显示文摘 | Tosun C Timothy D J Ozturk Y | 2003 | Journal of Sustainable Tourism2003，11，2： | 1 |
| 17 | An insitu approach for measuring root - associated respiration and nitrate uptake of forest trees 显示文摘 | Timothy J F Joseph B Y | 2005 | Plant and Soil2005，272，： | 1 |
| 18 | Inheritance,gene expression and lignin characterization in a mutant pine deficient in cinnamyl alcohol dehydrogenase显示文摘 | JOHN J MACKA Y DAVID M OPMALL E Y TIMOTHY P | 1997 | Proceeding of National Academic Science USA1997，94，： | 1 |
| 19 | Tourism Growth, National Development and Regional Inequality in Turkey显示文摘 | TOSUN C TIMOTHY D J OZTURK Y | 2003 | Journal Sustainable Tourism2003，11，2： | 1 |
| 20 | Tourism Growth, National Development and Regional Inequality in Turkey显示文摘 | TOSUN C TIMOTHY D J ZTRK Y | 2003 | Journal of Sustainable Tourism2003，，23： | 1 |
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