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| 1 | Epidemic Update and Risk Assessment of 2019 Novel Coronavirus--China, January 28, 2020显示文摘On December 29,2019,the health authorities in Hubei Province and Wuhan City received a report of a cluster of pneumonia cases of unknown etiology from a local hospital,and all four patients were employees of the Wuhan Huanan Seafood Wholesale Market(HN market for short)(1).By January 8,2020,Chinese authorities had identified a new virus 2019 novel coronavirus(2019-nCoV)linked with the outbreak of disease,which has been named novel coronavirusinfected pneumonia(NCIP)(2).On 15 January,the National Health Commission(NHC)issued guidelines for the diagnosis,treatment,prevention,and control of NCIP.These guidelines directed case monitoring,reporting,diagnosis,treatment,management,close contact management,and laboratory testing. | Wenxiao Tu Houlin Tang Fangfang Chen Yinong Wei Tingling Xu Kaiju Liao Nijian Xiang Guoqing Shi Qun Li Zijian Feng | 2020 | China CDC weekly2020，2，6： | 15 |
| 2 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 3 | Synchrotron radiation XRF microprobe investigation of elemental distribution in femoral head slice with osteoporosis显示文摘This note deals with the scanning of femoral head slices from both normal and osteoporosis subjects using synchrotron radiation X-ray fluorescence (SRXRF) microprobe technique. The sample preparation and experimental apparatus are described in detail. The quantitative computerized tomography (QCT) of elemental distribution, such as Ca, P, K, Fe, Zn, Sr and Pb in bone slice tissue including cartilage, substantial compact and substantial spongy, is investigated. Combined with the correlation between P, K, Zn, Sr and Ca, the loss way of minerals and the physiological functions of some metal elements in bone are also discussed. | ZHANG Yuanxun CHENG Feng LI Deyi WANG Yinsong ZHANG Guilin XU Hongjie LIAO Wensheng TANG Tingling HUANG Yuying HE Wei | 2001 | Chinese Science Bulletin2001，46，13： | 3 |
| 4 | Role of anti-stromal polypharmacy in increasing survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma显示文摘AIM: To investigate the survival impact of common pharmaceuticals, which target stromal interactions, following a pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. METHODS: Data was collected retrospectively for 164 patients who underwent a pancreaticoduodenectomy for pancreatic ductal adenocarcinoma(PDAC). Survival analysis was performed on patients receiving the following medications: angiotensin-converting enzyme inhibitors(ACEI)/angiotensin Ⅱ receptor blockers(ARB), calcium channel blockers(CCB), aspirin, and statins. Statistical analysis included Kaplan-meier survival estimates and cox multivariate regression; the latter of which allowed for any differences in a range of prognostic indicators between groups. Medications showing a significant survival benefit were investigated in combination with other medications to evaluate synergistic effects.RESULTS: No survival benefit was observed with respect to ACEI/ARB(n = 41), aspirin or statins on individual drug analysis(n = 39). However, the entire CCB group(n = 26) showed a significant survival benefit on multivariate cox regression; hazard ratio(HR) of 0.475(CI = 0.250-0.902, P = 0.023). Further analysis revealed that this was influenced by a group of patients who were taking aspirin in combination with CCB; median survival was significantly higher in the CCB + aspirin group(n = 15) compared with the group taking neither drug(n = 98); 1414 d vs 601 d(P = 0.029, logrank test). Multivariate cox regression revealed neither aspirin nor CCB had a statistically significant impact on survival when given alone, however in combination the survival benefit was significant; HR = 0.332(CI = 0.126-0.870, P = 0.025). None of the other medications showed a survival benefit in any combination.CONCLUSION: Aspirin + CCB in combination appears to increase survival in patients with PDAC, highlighting the potential clinical use of combination therapy to target stromal interactions in pancreatic cancer. | Samuel J Tingle John A Moir Steven A White | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 2 |
| 5 | 聚缩醛树脂义齿修复KennedyⅡ类牙列缺损的生物力学研究显示文摘目的利用光弹模型研究聚缩醛树脂义齿(隐形义齿)修复KennedyⅡ类牙列缺损的生物力学。方法建立下颌KennedyⅡ类牙列缺损((?)缺失)光弹模型,分别设计和制作聚缩醛树脂全隐形义齿、混合型隐形义齿和传统的金属支架可摘局部义齿。模拟双侧及单侧后牙加载,观察加载时三种义齿设计基牙和缺牙区牙槽嵴的载荷光弹图像,分别记录应力分布情况并加以分析和比较。结果三种义齿设计光弹模型应力分布分析显示,在单侧和双侧加载时,全隐形义齿基牙和缺牙区牙槽嵴承受压力最大,传统的金属支架可摘局部义齿(金属支架设计)承受压力沿基牙牙体长轴传导,基牙和剩余牙槽嵴承受压力最小且分布最均匀。结论对于KennedyⅡ类牙列缺损,全隐形义齿修复对基牙和剩余牙槽嵴损伤较大;而传统的金属支架可摘局部义齿使支持组织受力均匀、合理,应作为设计的首选。 | 焦婷 Tingling Chang Angelo A.Caputo | 2010 | 上海交通大学学报(医学版)2010，30，4： | 2 |
| 6 | Ovipostional responses of three Heliothis species ( Lepidoptrea: Noctuidae) to allelo chemicals from cultivated and wild host plants 显示文摘 | MITCHELL E R TINGLE F C HEATH R R | 1990 | Chem Ecol1990，16，6： | 1 |
| 7 | Identification of immunoreactive regions of rubella virus E1 and E2 envelope proteins by using synthetic peptides显示文摘 | Mitchell L A Decarie D Tingle A J Zrein M Lacroix M | 1993 | VirusRes1993，29，1： | 1 |
| 8 | Engineering properties of sand-fiber mixtures for road construction 显示文摘 | Santoni R L Tingle J S Webster S L | 2001 | Journal of Geotechnical and Geoenvironmental Engineering2001，127，3： | 1 |
| 9 | Ovipositional response of three Heliothis species (Lepidoptera: Noctuidae) to allelochemicals from cultivated and wild host plants显示文摘 | E. R. Mitchell P. C. Tingle R. R. Heath | 1990 | Journal of Chemical Ecology1990，，6： | 1 |
| 10 | Stabilization mechanisms of nontraditional additives显示文摘 | Tingle J S Newman J K Larson S L | 2007 | Transportation Research Record2007，1989，2： | 1 |
| 11 | Febrile seizures : risks, E- valuation, And prognosis 显示文摘 | Graves RC Oehler K Tingle LE | 2012 | Am Fam Physician2012，85，2： | 1 |
| 12 | Accelerated strength improvement of silty sand with nontraditional additives显示文摘 | SANTONI R L TINGLE J S N]EVES M | 2005 | Transportation Research Record: Journal of the Transportation Research Board2005，1936，1： | 1 |
| 13 | An exploration of enterprise technology selection and evaluation显示文摘 | TINGLING P PARENT M | 2004 | Journal of Strategic Information Systems2004，13，： | 1 |
| 14 | Construction of a series of pCS2+ backbone- based Gateway vectors for overexpressing various tagged proteins in vertebrates显示文摘网关向量广泛地被开发了便于基因在众多的种类克隆;然而,为多重有机体是兼容的一个通用系统正在缺乏。作为多种用途的表示向量, pCS2+ 基于脊梁的表示 plasmids 广泛地在哺乳动物 / 鸟的文化房间或 Xenopus/zebrafish 胚胎为送信人 RNA (mRNAs ) 或蛋白质的高级表示被使用。迄今为止,有为克隆系统的网关适用的 pCS2+ 脊梁的向量的一间套房还是无法获得的。这里,我们产生了一套网关目的地向量,作为 pGCS (在 pCS2+ 的网关的 plasmids ) 说出向量,它能被熔化到一种选择经常使用氨基终端或 carboxyl 终端标签包括 MYC,哈,旗帜,他的, GST,以及 eGFP 荧光灯 epitope。这的系统的产生将基于脊梁的网关目的地向量放 pCS2+ 与克隆途径的传统的消化结扎相比以高速度,精确性,和可靠性在 DNA 的 vitro 再结合允许。因此,我们的系统加速功能的蛋白质的生产,没有沉闷地把基因变成不同表达式向量,它能广泛地在脊椎动物有机体的一个大变化被表示。而且,我们经由非盈利的 Addgene Plasmid 仓库做对研究社区可得到的网关向量的这个系列。 | Hong-Yan Wang Yang Li Tingling Xue Ningyan Cheng Hai-Ning Du | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 1 |
| 15 | The response to anal gesia testing is affected by gonadal steroids in the rat显示文摘 | Forman L J Tingle V Estilow S Cater J | 1989 | Life Sci1989，45，： | 1 |
| 16 | Fipronil: Environmental fate, ecotoxicology, and human health concerns 显示文摘 | Tingle C C Rother J A Dewhurst C F | 2003 | Reviews of Environmental Contamination and Toxicology2003，176，： | 1 |
| 17 | UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term 显示文摘 | Collier AC Ganley NA Tingle MD | 2002 | Biochem Pharmacol2002，63，： | 1 |
| 18 | Febrile seizures: risks, evaluation, and prognosis显示文摘 | Graves R C Oehler K Tingle L E | 2012 | Am Fam Physician2012，85，2： | 1 |
| 19 | Improvements to Griggs-Type Apparatus for Mechanical Testing at High Pressures and Temperatures显示文摘 | Tingle T N Green H W Young T E | 1993 | Pure Appl Geophys1993，141，： | 1 |
| 20 | Evaluation of dust palliatives for unpaved roads in arid climates 显示文摘 | Rushing J F Harrison A Tingle J S | 2006 | Journal of Performance of Constructed Facilities2006，20，3： | 1 |
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