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| 1 | Protein-only' or 'virino' in prion diseases?显示文摘60-year prion and scrapie research has led to a dilemma in understanding the unknown aetiology of the infectious neurodegenerative disorders with intriguing features. Current progress and dilemma in prion research are briefly but critically reviewed. Instead of providing a comprehensive coverage of the research history, attentions in this view are drawn toward both the major breakthrough in the advancement of protein-only hypothesis, and the puzzle why this hypothesis has not been fully accepted. In order to resolve the prion enigma in neuroscience, it is suggested that both technical and concept barriers remain to be crossed. Since prion research is a multi-interdisciplinary subject, this view is intended to both facilitate a bette r understanding of prion phenomenon by more scientists in natural science, and invite scientists outside the fields of molecular genetics and protein science for collaboration. | YANG Chiming (Chi Ming Yang) & CHEN Yi1. Institute for Life Science and Health at UCSD, P.O.Box 12035, La Jolla, CA 92039, USA 2. Institute of Chemistry, Academy of Sciences, Beijing 100080, China Correspondence should be addressed to Yang Chiming | 2000 | Chinese Science Bulletin2000，45，3： | 2 |
| 2 | Immuno- histochemical and molecular subtypes of breast cancer in Ni- geria显示文摘 | Adebamowo CA Famooto A Ogundiran TO | 2008 | Breast Cancer Res Treat2008，110，： | 1 |
| 3 | A prospective evaluation of 'see anet treat' in women with HSIL Pap smear results:is this an appropriate atrategy显示文摘 | Numnum TM Kirby TO Leath CA 3rd | 2005 | J Low Oenit Tract Dis2005，9，： | 1 |
| 4 | Boothroyd C 显示文摘 | Smith CA de Lacey S Chapman M Acupuncture to im- prove live birth rates for women undergoing in vitro fertilization : a protocol for a randomized controlled trial | 2012 | Trials2012，13，： | 1 |
| 5 | Carvedilol decrease I-1βand TNF-α,inhibits MMP-2,MMP-9,COX-2,and RANKL expression,and up-regulates OPG in a rat model of periodontitis显示文摘 | de Araújo Júnior RF Souza TO de Medeiros CA | 2013 | PLoS One2013，8，66： | 1 |
| 6 | Prediction of pa-tientspecific risk of early preterm delivery using maternal histo-ry and sonographic measurement of cervical length:a popula-tion-based prospective study显示文摘 | To MS Skentou CA Royston P | 2006 | Ultrasound Obstet Gyne-col2006，27，： | 1 |
| 7 | Emerging breast cancer epidemic: evidence from Africa显示文摘 | Akarolo-Anthony 5N Ogundiran TO Adebamowo CA | 2010 | Breast Cancer Res2010，12，4： | 1 |
| 8 | Developmental issues in the impact of child maltreatment on later delinquency and drug use显示文摘 | Ireland TO Smith CA Thornberry TP | 2002 | Criminology2002，40，2： | 1 |
| 9 | Prediction of patient-specific risk of early preterm delivery using maternal history and sonographic measurement of cervical length:a population-based prospective study显示文摘 | To MS Skentou CA Royston P | 2006 | Ultrasound Obstet Gynecol2006，27，4： | 1 |
| 10 | A prospective evaluation of 'see and treat' in women with HSIL Pap smear results:is this an appropriate strategy显示文摘 | Numnum TM Kirby TO Leath CA 3rd | 2005 | J Low Genit Tract Dis2005，9，： | 1 |
| 11 | In-vivo diagnosis of persistent and recurrent nasopharyngeal carcinoma by contact endoscopy显示文摘 | PAK MW TO KF LEUNG SF VAN HASSELT CA | 2002 | Laryngoscope2002，112，： | 1 |
| 12 | Voice quality changes following phonatory-respiratory effort treatment (LSVT) versus respiratory effort treatment for individuals with Parkinson dis- ease显示文摘 | Baumgartner CA Sapir S Ramig TO | 2001 | J Voice2001，15，1： | 1 |
| 13 | Extended follow - up results of the PolarCath IDE study of the use of eryoplasty in femoropopliteal lesions 显示文摘 | McNamara TO Anaya CA Quinn BJ | 2006 | J Vase Interv Radiol2006，17，： | 1 |
| 14 | Masquerade without a mass: an unusual cause of severe acute pancreatitis显示文摘 | To CA Quigley MM Saven A | 2013 | J Gastrointest Oncol2013，4，1： | 1 |
| 15 | Surgical staging in endometrial cancer显示文摘 | Kinby TO Leath CA 3rd Kilgore LC | 2006 | Oncology( Williston Park )2006，20，1： | 1 |
| 16 | An exploratory study显示文摘 | Stifler CA Anzman - Frasca S Birch LL et aL Parent use of food to soothe infant/toddler distress and child weight status | 2010 | Appetite2010，57，3： | 1 |
| 17 | The neurobiology of childhood spinal muscular atrophy显示文摘 | Crawford TO Pardo CA | 1996 | Neurobiol Dis1996，3，2： | 1 |
| 18 | 显示文摘 | Hujoel PP Makinen KK Bennett CA The optimum time to initiate habitual xylitol gum-chewing for obtaining long-term caries prevention | 1999 | J Dent Res1999，78，3： | 1 |
| 19 | 显示文摘 | van Kleffens M Groffen CA Dits NF Lindenbergh-Kortleve DJ Schuller AG Bradshaw SL Pintar JE Zwartlaoff EC Drop SL & van Neck JW Generation of antisera to mouse insulin-like growth factor binding proteins (IGFBP) -1 to -6: comparison of IGFBP protein and messenger ribonucleic acid localization in the mouse embryo | 1999 | Endoerinology1999，140，： | 1 |
| 20 | 8-resistant sodium channel C-fibers causes retrograde mechanical nociceptor sensitization 显示文摘 | Parada CA Vivancos GG Tambeli CH de Queiroz Cunha F Ferreira SH: Activation ofpresynaptic NMDA receptors coupled to Navl | 2003 | Proc Natl Acad Sci USA2003，100，5： | 1 |
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