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| 1 | MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside显示文摘MicroRNAs(miRNAs) are small, single-stranded, noncoding RNAs that can post-transcriptionally regulate the expression of various oncogenes and tumor suppressor genes. Dysregulated expression of many miRNAs have been shown to mediate the signaling pathways critical in the multistep carcinogenesis of colorectal cancer(CRC). MiR NAs are stable and protected from RNase-mediated degradation, thereby enabling its detection in biological fluids and archival tissues for biomarker studies. This review focuses on the role and application of miRNAs in the prognosis and therapy of CRC. While stage Ⅱ CRC is potentially curable by surgical resection, a significant percentage of stage Ⅱ CRC patients do develop recurrence. MiRNA biomarkers may be used to stratify such high-risk population for adjuvant chemotherapy to provide better prognoses. Growing evidence also suggests that miRNAs are involved in the metastatic process of CRC. Certain of these miRNAs may thus be used as prognostic biomarkers to identify patients more likely to have micro-metastasis, who could be monitored more closely after surgery and/or given more aggressive adjuvant chemotherapy. Intrinsic and acquired resistance to chemotherapy severely hinders successful chemotherapy in CRC treatment. Predictive miRNA biomarkers for response to chemotherapy may identify patients who will benefit the most from a particular regimen and also spare the patients from unnecessary side effects. Selection of patients to receive the new targeted therapy is becoming possible with the use of predictive miRNA biomarkers. Lastly, forced expression of tumor suppressor miRNA or silencing of oncogenic miRNA in tumors by gene therapy can also be adopted to treat CRC alone or in combination with other chemotherapeutic drugs. | Kenneth KW To Christy WS Tong Mingxia Wu William CS Cho | 2018 | World Journal of Gastroenterology2018，24，27： | 29 |
| 2 | Modulation of LMP1 protein expression by EBV-encoded microRNAs显示文摘 | Lo AK To KF Lo KW | 2007 | Proe Natl Acad Sci U S A2007，104，16： | 1 |
| 3 | Frequent death-associated protein kinase promoter hypermethylation in multiple myeloma显示文摘 | Ng MH To KW Lo KW | 2001 | Clin Cancer Res2001，7，6： | 1 |
| 4 | Radiological prognosticators of hepatocellular carcinoma treated by hepatectomy显示文摘BACKGROUND: Hepatectomy is the main curative treatment for hepatocellular carcinoma (HCC), but postoperative long- term survival is poor. Preoperative radiological features of HCC displayed by computed tomography or magnetic resonance imaging could serve as additional prognostic factors. This study aimed to identify preoperative radiological features of HCC that may be of prognostic significance in hepatectomy. METHODS: Ninety-two patients who underwent hepatectomy for HCC were included in this study. Preoperative radiological features including tumor number, size, location (peripheral, middle, central), portal vein invasion, hepatic vein invasion, and presence of pseudo-capsule were analyzed in relation to survival. RESULTS: With a median follow-up period of 41.7 months, the 1-, 3- and 5-year overall survival rates were 85%, 65% and 58%, respectively. Univariate analysis showed that portal vein invasion and absence of pseudo-capsule were significant prognostic factors for overall survival, while all the examined radiological features were prognostic factors for disease-free survival. Multivariate analysis for overall survival found no significant factor. On multivariate analysis for disease-free survival, patients who had tumors with portal vein invasion had poorer survival with a hazard ratio of 2.26 (95% CI, 1.05-4.91; P=0.038) and patients with single nodular HCC or pseudo-capsulated HCC had better survival with a hazard ratio of 0.50 (95% CI, 0.27-0.94; P=0.032) and 0.38 (95% CI, 0.14-0.99; P=0.048), respectively. CONCLUSIONS: Demonstrable pseudo-capsule of HCC and solitary HCC on imaging and absence of portal vein invasionare features associated with better disease-free survival after hepatectomy. These features may guide treatment planning for HCC. | Kevin KW Chu See Ching Chan Sheung Tat Fan Kenneth SH Chok Tan To Cheung William W Sharr Albert CY Chan Chung Mau Lo | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，6： | 1 |
| 5 | Frequent death-associated protein kinase promoter hypermethylation in multiple myeloma显示文摘 | Ng MH To KW Lo KW Chan S Tsang KS Cheng SH | 2001 | Clin Cancer Res2001，7，： | 1 |
| 6 | Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma显示文摘 | Kwong J Lo KW To KF | 2002 | Clin Cancer Res2002，8，1： | 1 |
| 7 | Focus on nasopharyngeal carcinoma 显示文摘 | Lo KW To KF Huang DP | 2004 | Cancer Cell2004，5，： | 1 |
| 8 | A rare case of primary omental neu- roblastoma and resection of the recurrent tumor by laparoscopy显示文摘 | Chan KW Lee KH To KF | 2009 | Pe- diatr Surg Int2009，25，2： | 1 |
| 9 | Modulation of LMP1 protein expression by EBV-encoded microRNAs显示文摘 | Lo AK To KF Lo KW | 2007 | Proc Natl Acad Sci U S A2007，104，16： | 1 |
| 10 | Mesenteric fat thickness is as-sociated with increased risk of obstructive sleep apnoea显示文摘 | Liu KH Chu WC To KW | 2014 | Re-spirology2014，19，1： | 1 |
| 11 | Promoter hypermethylation of multiple genes in nasopharyngeal earcinoma显示文摘 | Kwong J Lo KW To KF | 2002 | Clin Cancer Res2002，8，1： | 1 |
| 12 | Validation of Embletta portable diagnostic system for identifying patients with suspected obstructive sleep apnoea syndrome (OSAS)显示文摘 | Ng SS Chan TO To KW | 2010 | Respirology2010，15，2： | 1 |
| 13 | Promoter hypermethylation of multiple genes in nasopharyneal carcinoma显示文摘 | Kwong J Lo KW To KF | 2002 | Clin Cancer Res2002，8，： | 1 |
| 14 | Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma显示文摘 | Kwong J Lo KW To KF | 2002 | Clin Cancer Res2002，8，1： | 1 |
| 15 | Promoter hypermethylation of mul- tiple genes in nasopharyngeal carcinoma 显示文摘 | Kwong J Lo KW To KF | 2002 | Clin Cancer Res2002，8，1： | 1 |
| 16 | Modulation of LMP1 protein expression by EBV-encoded microRNAs显示文摘 | Lo AK To KF Lo KW | 2007 | Proc Natl Acad Sci USA2007，104，16： | 1 |
| 17 | Focus on nasopharyngeal carcinoma 显示文摘 | Lo KW To KF Huang DP | 2004 | Cancer Cell2004，5，5： | 1 |
| 18 | Nasal CPAP reduces systemic blood pressure in patients with obstructive sleep apnoea and mild sleepiness显示文摘 | Hui DS To KW Ko FW | 2006 | Thorax2006，61，12： | 1 |
| 19 | High frequency of chromosome3p deletion in histologically normal nasopharyngeal epithelia from southern Chinese显示文摘 | Chan AS To KF Lo KW | 2000 | Cancer Res2000，60，19： | 1 |
| 20 | Azithromycin treatment failure in macrolide-resistant Mycoplasma pneumoniae pneumonia显示文摘 | To KW Chan KH Fung YF | | 0，，04： | 1 |
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