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| 1 | AFP level and histologic differentiation predict the survival of patients with liver transplantation for hepatocellular carcinoma显示文摘BACKGROUND: In liver transplantation or resection for hepatocellular carcinoma (HCC), patient selection depends on morphological features. In patients with HCC, we performed a clinicopathological analysis of risk factors that affected survival after liver transplantation. METHODS: In 389 liver transplantations performed from 2004 to 2010, 102 were for HCC patients. Data were collected retrospectively from the Organ Transplantation Center Database. Variables were as follows: age, gender, preoperative alpha-fetoprotein (AFP) levels, Child-Pugh and MELD scores, prognostic staging criteria (Milan and UCSF), etiology, number of tumors, the largest tumor size, total tumor size, multifocality, intrahepatic portal vein tumor thrombosis, bilobarity, and histological differentiation. RESULTS: One hundred and two patients were evaluated. The 5-year overall survival rate was 56.5%. According to the UCSF criteria, 63% of the patients were within and 37% were beyond UCSF (P=0.03). Ten patients were excluded (one with fibrolamellary HCC and 9 because of early postoperative death without HCC recurrence), and 92 patients were assessed. The mean age of the patients was 56.5±6.9 years. Sixty-two patients underwent living donor liver transplantations. The mean follow-up time was 29.4±22.6 months. Fifteen patients (16.3%) died in the follow-up period due to HCC recurrence. Univariate analysis showed that AFP level, intrahepatic portal vein tumor thrombosis, histologic differentiation and UCSF criteria were significant factors related to survival and tumor recurrence. The 5-year estimated overall survival rate was 62.2% in allpatients. According to the UCSF criteria, and the 5-year overall survival rate was 66.7% within and 52.7% beyond the criteria (P=0.04). Multivariate analysis showed that AFP level and poor differentiation were independent factors. CONCLUSIONS: For proper patient selection in liver trans- plantation for HCC, prognostic criteria related to tumor biology (especially AFP level and histological differentiation) should be considered. Poor differentiation and higher AFP levels are indicators of poor prognosis after liver transplantation. | Onur Yaprak Murat Akyildiz Murat Dayangac Baha Tolga Demirbas Necdet Guler Gulen Bulbul Dogusoy Yildiray Yuzer Yaman Tokat | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 15 |
| 2 | ASYMPTOTIC BEHAVIOUR OF EIGENVALUES FOR THE DISCONTINUOUS BOUNDARY-VALUE PROBLEM WITH FUNCTIONAL-TRANSMISSION CONDITIONS显示文摘In this study, the boundary-value problem with eigenvalue parameter generated by the differential equation with discontinuous coefficients and boundary conditions which contains not only endpoints of the considered interval, but also point of discontinuity and linear functionals is investigated. So, the problem is not pure boundary-value. The authors single out a class of linear functionals and find simple algebraic conditions on coefficients, which garantee the existence of innnit number eigenvalues. Also the asymptotic formulas for eigenvalues are found. | O.Sh.Mukhtarov Department of Mathematics, Science and Arts Faculty, Gaziosmanpasa University, Tokat, TurkeyMustafa Kandemir Department of Mathematics, Faculty of A mas y a Education, Ondokuz Mayis University, Amasya, Turkey | 2002 | Acta Mathematica Scientia2002，22，3： | 10 |
| 3 | Glasgow coma scale and APACHE-II scores affect the liver transplantation outcomes in patients with acute liver failure显示文摘BACKGROUND:The timing and selection of patients for liver transplantation in acute liver failure are great challenges.This study aimed to investigate the effect of Glasgow coma scale(GCS)and APACHE-II scores on liver transplantation outcomes in patients with acute liver failure.METHOD:A total of 25 patients with acute liver failure were retrospectively analyzed according to age,etiology,time to transplantation,coma scores,complications and mortality.RESULTS:Eighteen patients received transplants from live donors and 7 had cadaveric whole liver transplants.The mean duration of follow-up after liver transplantation was 39.86±40.23 months.Seven patients died within the perioperative period and the 1-,3-,5-year survival rates of the patients were72%,72%and 60%,respectively.The parameters evaluated for the perioperative deaths versus alive were as follows:the mean age of the patients was 33.71 vs 28 years,MELD score was 40 vs32.66,GCS was 5.57 vs 10.16,APACHE-II score was 23 vs 18.11,serum sodium level was 138.57 vs 138.44 mmol/L,mean waiting time before the operation was 12 vs 5.16 days.Low GCS,high APACHE-II score and longer waiting time before the operation(P<0.01)were found as statistically significant factors for perioperative mortality.CONCLUSION:Lower GCS and higher APACHE-II scores are related to poor outcomes in patients with acute liver failure after liver transplantation. | Necdet Guler Omer Unalp Ayse Guler Onur Yaprak Murat Dayangac Murat Sozbilen Murat Akyildiz Yaman Tokat | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 9 |
| 4 | Major complications of adult right lobe living liver donors显示文摘BACKGROUND:The right lobe of the liver is generally preferred for living donor liver transplantation in adult patients with end-stage liver disease.It is important to know the preoperative factors relating to the major postoperative complications.We therefore evaluated the possible risk factors for predicting postoperative complications in right lobe liver donors.METHODS:Data from 378 donors who had undergone | Necdet Guler Onur Yaprak Yusuf Gunay Murat Dayangac Murat Akyildiz Fisun Yuzer Yildiray Yuzer Yaman Tokat | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 3 |
| 5 | Living donor liver hilar variations: surgical approaches and implications显示文摘BACKGROUND: Varied vascular and biliary anatomies are common in the liver. Living donor hepatectomy requires precise recognition of the hilar anatomy. This study was undertaken to study donor vascular and biliary tract variations, surgical approaches and implications in living liver transplant patients. METHODS: Two hundred living donor liver transplantations were performed at our institution between 2004 and 2009. All donors were evaluated by volumetric computerized tomography (CT), CT angiography and magnetic resonance cholangiography in the preoperative period. Intraoperative ultrasonography and cholangiography were carried out. Arterial, portal and biliary anatomies were classified according to the Michels, Cheng and Huang criteria. RESULTS: Classical hepatic arterial anatomy was observed in 129 (64.5%) of the 200 donors. Fifteen percent of the donors had variation in the portal vein. Normal biliary anatomy was found in 126 (63%) donors, and biliary tract variation in 70% of donors with portal vein variations. In recipients with single duct biliary anastomosis, 16 (14.4%) developed biliary leak, and 9 (8.1%) developed biliary stricture; however more than one biliary anastomosis increased recipient biliary complications. Donor vascular variations did not increase recipient vascular complications. Variant anatomy was not associated with an increase in donor morbidity. CONCLUSIONS: Living donor liver transplantation provides information about variant hilar anatomy. The success of the procedure depends on a careful approach to anatomical variations. When the deceased donor supply is inadequate living donor transplantation is a life-saving alternative and is safe for the donor and recipient, even if the donor has variant hilar anatomy. | Onur Yaprak Tolga Demirbas Cihan Duran Murat Dayangac Murat Akyildiz Yaman Tokat Yildiray Yuzer | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 2 |
| 6 | Color removal from cotton textile industry wastewater in an activated sludge system with various additives显示文摘 | PALA A TOKAT E | 2002 | Water Research2002，36，11： | 1 |
| 7 | Causos of postrepeffusion syndrome in living or oadaveric donor 显示文摘 | Ayanoglu HO U lukaya S Tokat Y | 2003 | Transplant Proe2003，35，4： | 1 |
| 8 | Comparison of the efficacy of 2 mg versus 5 mg tropisetron in the management of post-operative nausea and vomiting 显示文摘 | Yilmazlar A Tokat O Kutlay O | 2001 | J Int Med Res2001，29，5： | 1 |
| 9 | Which urine marker test provides more diagnostic value in conjunction with standard cytology-ImmunoCyt/uCyt+ or Cytokeratin,20 expression显示文摘 | Soyuer I Sofikerim M Tokat F Soyuer S Ozturk F | | 0，，： | 1 |
| 10 | The Stable Non-Gaussian Asset Allocation:A Comparison with the Classical Gaussian Approach显示文摘 | Rachev S T Schwartz E S | 2003 | Journal of Economic Dynamics and Control2003，27，6： | 1 |
| 11 | Causes of postreperfusion syndrome in living or cadaveric donor liver transplantations显示文摘 | Ayanoglu HO Ulukayas S Tokat Y | 2003 | Transplant Proc2003，35，4： | 1 |
| 12 | Which urine marker test pro- vides more diagnostic value in conjunction with standard cytology- ImmunoCyt/uCyt plus or Cytokeratin 20 expression 显示文摘 | Soyuer I Sofikerim M Tokat F | 2009 | Diagn Pathol2009，4，6： | 1 |
| 13 | Use of the laryngeal mask airway in children with subglottic stenosis 显示文摘 | Yavascaoglu B Tokat O Basagan E | 2001 | J Int Med Res2001，29，6： | 1 |
| 14 | Color removel from cotton textile industry wasterwater in an activated sludge system with various additives显示文摘 | Pala A Tokat E | 2002 | Water Research2002，36，11： | 1 |
| 15 | Which urine marker test provides more diagnostic value in conjunction with standard cytolo- gy- ImmunoCyt/uCyt + or Cytokeratin 20 expression 显示文摘 | Soyuer I Sofikerim M Tokat F | 2009 | Diagn Pathol2009，4，1： | 1 |
| 16 | Early postpartum breast-feeding outcomes and breast-feeding self-efficacy in Turkish mothers undergoing vaginal birth or cesarean birth with different types of anesthesia显示文摘 | Alus Tokat M Sercekus P Yenal K | 2015 | Int J Nurs Knowl2015，26，2： | 1 |
| 17 | The Stable Non-Gaussian Asset Allocation:A Comparison with the Classical Gaussian Approach显示文摘 | TOKAT Y RACHEV S T SCHWARTZ E S | 2003 | Journal of Economic Dynamics and Control2003，27，6： | 1 |
| 18 | Color removal from cotton textile industry wastewater in an activated sludge system with various additives 显示文摘 | Pala A Tokat E 2002 | 2002 | Water Research2002，36，11： | 1 |
| 19 | Cause of postperfusion syndrome in living or cadaveric donor liver transplantation显示文摘 | Ayanoglu HO UIukaya S Tokat Y | 2003 | Transplant Proc2003，35，4： | 1 |
| 20 | The Stable Non-Gaussian Asset Allocation:A Comparison with the Classical Gaussian Approach显示文摘 | Tokat Y Rachev S T Schwartz E S | 2003 | Journal of Economic Dynamics and Control2003，27，6： | 1 |
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