|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of time from diagnosis to chemotherapy in advanced gastric cancer: A Propensity Score Matching Study to Balance Prognostic Factors显示文摘BACKGROUND It is unclear whether treatment delay affects the clinical outcomes of chemotherapy in advanced gastric cancer(A-GC).AIM To assess whether treatment delay affects the clinical outcomes of chemotherapy in A-GC.METHODS This single-center retrospective study examined consecutive patients with A-GC between April 2012 and July 2018. In total, 110 patients with stage Ⅳ A-GC who underwent chemotherapy were enrolled. We defined the wait time(WT) as the interval between diagnosis and chemotherapy initiation. We evaluated the influence of WT on overall survival(OS).RESULTS The mean OS was 303 d. The median WT was 17 d. We divided the patients into early and elective WT groups, with a 2-wk cutoff point. There were 46 and 64 patients in the early and elective WT groups, respectively. Compared with the elective WT group, the early WT group had significantly lower albumin(Alb)levels and higher neutrophil/lymphocyte ratios and C-reactive protein(CRP)levels but not a lower performance status. The elective WT group underwent more combination chemotherapy than did the early WT group. OS was different between the two groups(230 d vs 340 d, respectively). Multivariate analysis revealed that higher CRP levels, lower Alb levels and monotherapy were significantly related to a poor prognosis. To minimize potential selection bias,patients in the elective WT group were 1:1 propensity score matched with patients in the early WT group; no significant difference in OS was found(303 d vs 311 d, respectively, log-rank P = 0.9832).CONCLUSION A longer WT in patients with A-GC does not appear to be associated with a worse prognosis. | Tsutomu Nishida Aya Sugimoto Ryo Tomita Yu Higaki Naoto Osugi Kei Takahashi Kaori Mukai Tokuhiro Matsubara Dai Nakamatsu Shiro Hayashi Masashi Yamamoto Sachiko Nakajima Koji Fukui Masami Inada | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 4 |
| 2 | Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘AIM To estimate the efficacy of 2 h post-endoscopic retrograde cholangiopancreatography(ERCP) serum amylase levels and other factors for predicting postERCP pancreatitis.METHODS This was a retrospective,single-center cohort study of consecutive patients who underwent ERCP from January 2010 to December 2013.Serum amylase levels were measured 2 h post-procedure,and patient- and procedure-related pancreatitis(PEP) risk factors wereanalyzed using a logistic model.RESULTS A total of 1520 cases(average age 72 ± 12 years,60% male) were initially enrolled in this study,and 1403 cases(725 patients) were ultimately analyzed after the exclusion of 117 cases.Fifty-five of these cases developed PEP.We established a 2 h serum amylase cutoff level of two times the upper limit of normal for predicting PEP.Multivariate analysis revealed that a cannulation time of more than 13 min [odds ratio(OR) 2.28,95%CI:1.132-4.651,P=0.0210] and 2 h amylase levels greater than the cutoff level(OR=24.1,95%CI:11.56-57.13,P<0.0001) were significant predictive factors for PEP.Forty-seven of the 55 patients who developed PEP exhibited 2 h amylase levels greater than the cutoff level(85%),and six of the remaining eight patients who developed PEP(75%) required longer cannulation times.Only 2 of the 1403 patients(0.14%) who developed PEP did not exhibit concerning 2 h amylase levels or require longer cannulation times.CONCLUSION These findings indicate that the combination of 2 h post-ERCP serum amylase levels and cannulation times represents a valuable marker for identifying patients at high risk for PEP. | Shiro Hayashi Tsutomu Nishida Hiromi Shimakoshi Akiyoshi Shimoda Takahiro Amano Aya Sugimoto Kei Takahashi Kaori Mukai Tokuhiro Matsubara Masashi Yamamoto Sachiko Nakajima Koji Fukui Masami Inada | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 4 |
| 3 | Clinically diagnosed late-onset fulminant Wilson's disease without cirrhosis: A case report显示文摘A 64-year-old woman was referred to our hospital with jaundice of the bulbar conjunctiva and general fatigue. After admission, she developed hepatic encephalopathy and was diagnosed with fulminant hepatitis based on the American Association for the Study of Liver Disease(AASLD) position paper. Afterwards, additional laboratory findings revealed that serum ceruloplasmin levels were reduced, urinary copper levels were greatly elevated and Wilson's disease(WD)-specific routine tests were positive, but the Kayser-Fleischer ring was not clear. Based on the AASLD practice guidelines for the diagnosis and treatment of WD, the patient was ultimately diagnosed with fulminant WD. Then, administration of penicillamine and zinc acetate was initiated; however, the patient unfortunately died from acute pneumonia on the 28 th day of hospitalization. At autopsy, the liver did not show a bridging pattern of fibrosis suggestive of chronic liver injury. Here, we present the case of a patient with clinically diagnosed late-onset fulminant WD without cirrhosis, who had positive disease-specific routine tests. | Takahiro Amano Tokuhiro Matsubara Tsutomu Nishida Hiromi Shimakoshi Akiyoshi Shimoda Aya Sugimoto Kei Takahashi Kaori Mukai Masashi Yamamoto Shiro Hayashi Sachiko Nakajima Koji Fukui Masami Inada | 2018 | World Journal of Gastroenterology2018，24，2： | 2 |
| 4 | Self- healing in networks with multiple reliability classes 显示文摘 | Tokuhiro K Jun T | 2001 | Electron Comm Jpn Part I2001，84，7： | 1 |
| 5 | An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis显示文摘 | TOKUHIRO S YAMADA R CHANG X | 2003 | Nat Genet2003，35，4： | 1 |
| 6 | Introduc- tion of the methyl group into the pyrazine ring 显示文摘 | Akihiro Ohta Akira Inoue Tokuhiro Watanabe | 1984 | Hetero- cycles1984，22，10： | 1 |
| 7 | D-lactic acid production by metabolically engineered Saccharomyces cerevisiae显示文摘 | Ishida N Suzuki T Tokuhiro K | 2006 | Journal of Bioscience and Bioengineer- ing2006，101，： | 1 |
| 8 | Early rehabilitation ef- fect for traumatic spinal cord injury显示文摘 | Sumida M Fujimoto M Tokuhiro A | 2001 | Arch Phys Med Rehabil2001，82，3： | 1 |
| 9 | Role of alternative splicing of periostin in human bladder carcinogenesis显示文摘 | Chul Kim Takahiro Isono Yukihiro Tambe Tokuhiro Chano Hidetoshi Okabe Yusaku Okada Hirokazu Inoue | 2008 | International Journal of Oncology2008，，1： | 1 |
| 10 | An experimentalinvestigation on thermal striping:Mixing phe-nomena of a vertical non-buoyant jet with two ad-jacent buoyant jets as measured by ultrasoundDoppler velocimetry显示文摘 | TOKUHIRO A KIMURA N | 1999 | Nucl Eng Des1999，188，1： | 1 |
| 11 | A novel compound, RS-1178, specifically inhibits neuronal cell death mediated by beta-amyloid-induced macrophage activation in vitro 显示文摘 | Uryu S Tokuhiro S Murasugi T Oda T | 2002 | Brain Res2002，946，2： | 1 |
| 12 | Numerical study on mixing of oscilla-ting quasi-planar jets显示文摘 | NISHIMURA M TOKUHIRO A KIMURAN | 2000 | Nucl Eng Des2000，202，1： | 1 |
| 13 | An experimental investigation on thermal striping: Mixing phenomena of a vertical non-buoyant jet with two adjacent buoyant jets as measured by ultrasound Doppler velocimetry显示文摘 | TOKUHIRO A KIMURA N | 1999 | Nuclear Engineering and Design1999，188，1： | 1 |
| 14 | Turbulent flow past a bubble and an ellipsoid using shadowimage and PIV techniques显示文摘 | Tokuhiro A Maekawa M Iizuka K Hishida K Maeda M | 1998 | International Journal of Multiphase Flow1998，，24： | 1 |
| 15 | Gadolinium-enhaneed MR imaging in the evaluation of uterine fibroids treated with u- terine artery embolization显示文摘 | Katsumori T Nakajima K Tokuhiro M | 2001 | A JR Am J Roentgenol2001，177，2： | 1 |
| 16 | Development of Metal-Carbon Eutectic Cells for Application as High Temperature Reference Points in Nuclear Reactor Severe Accident Tests:Results on the Fe-C,Co-C,Ti-C and Ru-C Alloys' Melting/Freezing Transformation Temperature under Electromagnetic Induction Heating显示文摘 | Parga C J Journeau C Tokuhiro A | 2012 | High Temperatures-High Pressures2012，41，6： | 1 |
| 17 | Association study of genetic polymorphisms of drug transporters, SLCO1BI, SLCO1B3 and AB- CC2, in African-Americans, Hispanics and Caucasians and olmesar- tan exposure显示文摘 | Endo S Fukahori A Tokuhiro S | 2012 | Journal of Human Genetics2012，57，： | 1 |
| 18 | Preparation of mouse monoclonal antibody for RB1CC1 and its clinical application 显示文摘 | Yusuke H Tokuhiro C Takuma I | 2012 | Plos One2012，7，： | 1 |
| 19 | Numerical study on mixing of oscillating quasi-planar jets 显示文摘 | NISHIMURA M TOKUHIRO A KIMURA N | 2000 | Nuclear Engineering and Design2000，202，1： | 1 |
| 20 | Beta-Amyloid-specifie upregulation of stearoyl coenzyme A desaturase- 1 in macrophages显示文摘 | Uryu S Tokuhiro S Ods T | 2003 | Biochem Biophys Res Commun2003，303，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员