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| 1 | Resection vs thermal ablation of small hepatocellular carcinoma:What's the first choice?显示文摘Nowadays,hepatocellular carcinoma(HCC) is frequently diagnosed at an early stage,opening good perspectives to radical treatment by means of liver transplantation,surgical resection,or percutaneous ablation.Liver transplantation is considered the best option,but the lack of liver donors represents a major limitation.Therefore,surgical resection,offering a 5-year-survival rate of over 50%,is considered the first-choice treatment for patients with early stage HCC,whereas percutaneous ablation is usually reserved to patients who are not candidate to surgery.However,in the recent years some trials showed that percutaneous radiofrequency ablation(RFA) can be as effective as surgical resection in terms of overall survival and recurrencefree survival rates in patients with small HCC,and a retrospective comparative study reported 1-,3-,and 5-year overall survival rates and recurrence-free survival rates significantly better in patients with central HCC measuring 2 cm or smaller treated with RFA than in those treated with surgical resection.RFA is less expensive,less invasive,with lower complication rate and shorter hospital stay than surgical resection,and on the basis of the results of these studies it should be considered the first option in the treatment of very early HCC.However,RFA is size-dependent,so at present the need to achieve an adequate safety margin around the tumor limits to about 2 cm the diameter of the nodules that can be ablated with long-term outcomes comparable to or better than surgical resection.The main goal of the next technical developments of the thermal ablation systems should be the achievement of larger ablation areas with a single needle insertion.In this regard,the recent improvements in microwave energy delivery systems seem to open interesting perspectives to percutaneous microwave ablation,which could become the ablation technique of choice in the next future. | Paola Tombesi Francesca Di Vece Sergio Sartori | 2013 | World Journal of Radiology2013，5，1： | 50 |
| 2 | Contrast-enhanced ultrasonography in peripheral lung consolidations: What's its actual role?显示文摘AIM:To evaluate the diagnostic accuracy of contrastenhanced ultrasonography(CEUS)in the differential diagnosis between neoplastic and non-neoplastic peripheral pleuro-pulmonary lesions.METHODS:One hundred patients with pleural or peripheral pulmonary lesions underwent thoracic CEUS.An 8 microliters/mL solution of sulfur hexafluoride microbubbles stabilized by a phospholipid shell(SonoVue)was used as US contrast agent.The clips were stored and independently reviewed by two readers,who recorded the following parameters:presence/absence of arterial enhancement,time to enhancement(TE),extent of enhancement(EE),pattern of enhancement(PE),presence/absence of wash-out,time to wash-out,and extent of wash-out.After the final diagnosis(based on histopathologic findings or follow-up of at least 15 mo)was reached,sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV),positive likelihood ratio(PLR),negative likelihood ratio(NLR)of each CEUS parameter in the differential diagnosis between neoplastic and nonneoplastic lesions were calculated.Furthermore,an arbitrary score based on the ratio between the PPVs of each CEUS parameter was calculated,to evaluate if some relationship could exist between overall CEUS behaviour and neoplastic or non-neoplastic nature of the lesions. | Sergio Sartori Simona Postorivo Francesca Di Vece Fran-cesca Ermili Davide Tassinari Paola Tombesi | 2013 | World Journal of Radiology2013，5，10： | 19 |
| 3 | Emerging roles for transthoracic ultrasonography in pulmonary diseases显示文摘As a result of many advantages such as the absence of radiation exposure,non-invasiveness,low cost,safety,and ready availability,transthoracic ultrasonography(TUS) represents an emerging and useful technique in the management of pleural and pulmonary diseases.In this second part of a comprehensive review that deals with the role of TUS in pleuropulmonary pathology,the normal findings,sonographic artifacts and morphology of the most important and frequent pulmonary diseases are described.In particular,the usefulness of TUS in diagnosing or raising suspicion of pneumonia,pulmonary embolism,atelectasis,diffuse parenchymal diseases,adult and newborn respiratory distress syndrome,lung cancer and lung metastases are discussed,as well as its role in guidance for diagnostic and therapeutic interventional procedures.Moreover,the preliminary data about the role of contrast enhanced ultrasonography in the study of pulmonary pleural-based lesions are also reported.Finally,the limits of TUS when compared with chest computed tomography are described,highlighting the inability of TUS to depict lesions that are not in contact with the pleura or are located under bony structures,poor visualization of the mediastinum,and the need for very experienced examiners to obtain reliable results. | Sergio Sartori Paola Tombesi | 2010 | World Journal of Radiology2010，2，6： | 18 |
| 4 | 经皮肝穿刺射频消融治疗包膜下肝肿瘤与非包膜下肝肿瘤效用与安全性的前瞻性对照研究显示文摘目的评价经皮肝穿刺射频(RF)消融治疗包膜下肝肿瘤的效用与安全性。方法本研究经伦理委员会批准,所有受试者都签署了知情同意书。18t例病人(男79例,女102例,年龄36~85岁)的361个原发或继发(转移的)肝肿瘤进行了超声引导下的经皮RF消融治疗。44例病人有1个或1个以上包膜下肿瘤(组1),137病人仅有非包膜下肿瘤(组2)。总共80个包膜下结节和281个非包膜下结节。RF消融后1个月进行增强CT扫描评价消融的完整性。如果CT显示肿瘤残留,则再次进行RF消融。所有1次或2次RF消融治疗后的病人,每3个月进行CT或增强US进行监控。 | S. Sartori P. Tombesi F. Macario I. Nielsen D. Tassinari M. Catellani 高莉(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 12 |
| 5 | Emerging roles for transthoracic ultrasonography in pleuropulmonary pathology显示文摘As a result of many advantages,such as absence of radiation exposure,non-invasiveness,low cost,safety, and ready availability,transthoracic ultrasonography (TUS) represents an emerging and useful technique in the management of pleural and pulmonary diseases. In this first part of a comprehensive review dealing with the role of TUS in pleuropulmonary pathology, the examination technique,limits,normal findings, and sonographic artefacts and morphology of the most important and frequent pleural diseases are described. In particular,this first part deals with the capability of TUS in detecting pleural effusion and differentiating pleural fluid from pleural thickening;its usefulness in detecting pneumothorax on the basis of the changes in the artefacts detectable in the normally aerated lung and the appearance of pathologic artefacts;and its role in detecting pleural-based lesions and classifying them into extrapleural,pleural,and parenchymal lesions.Finally,the limits of TUS when compared with computed tomography of the chest are described, highlighting the inability of TUS to depict lesions that are not in contact with the pleura or are located under bony structures,poor visualization of the mediastinum, and the need for very experienced examiners to obtain reliable results. | Sergio Sartori Paola Tombesi | 2010 | World Journal of Radiology2010，2，2： | 11 |
| 6 | Laser ablation of liver tumors:An ancillary technique,or an alternative to radiofrequency and microwave?显示文摘Radiofrequency ablation(RFA) is currently the most popular and used ablation modality for the treatment ofnon surgical patients with primary and secondary liver tumors, but in the last years microwave ablation(MWA) is being technically improved and widely rediscovered for clinical use. Laser thermal ablation(LTA) is by far less investigated and used than RFA and MWA, but the available data on its effectiveness and safety are quite good and comparable to those of RFA and MWA. All the three hyperthermia-based ablative techniques, when performed by skilled operators, can successfully treat all liver tumors eligible for thermal ablation, and to date in most centers of interventional oncology or interventional radiology the choice of the technique usually depends on the physician's preference and experience, or technical availability. However, RFA, MWA, and LTA have peculiar advantages and limitations that can make each of them more suitable than the other ones to treat patients and tumors with different characteristics. When all the three thermal ablation techniques are available, the choice among RFA, MWA, and LTA should be guided by their advantages and disadvantages, number, size, and location of the liver nodules, and cost-saving considerations, in order to give patients the best treatment option. | Sergio Sartori Francesca Di Vece Francesca Ermili Paola Tombesi | 2017 | World Journal of Radiology2017，9，3： | 6 |
| 7 | 在 Krukenberg 肿瘤的一种情况中的 ultrasonography 和提高对比的 ultrasonography 的角色显示文摘 We report a case of Krukenberg tumor of gastric origin with adnexal metastasis,in which ultrasonography(US) and contrast-enhanced US(CEUS) played a key diagnostic role.An 64-year-old female patient was referred to our department for abdominal pain,nausea and ascites.US examination was performed as first line diagnostic imaging approach,confirming the presence of ascites and detecting marked thickness of the gastric wall and a right adnexal mass.CEUS was immediately performed and showed arterial enhancement followed by wash-out in the venous phase of both the gastric wall and the adnexal mass,suggesting the diagnosis of gastric cancer with right adnexal metastasis(Krukenberg syndrome).The patient underwent USguided paracentesis and esophagogastroduodenoscopy that showed linitis plastica.Cytologic examination of the peritoneal fluid revealed the presence of signetring cells,and histologic examination of the specimen obtained by endoscopic biopsy showed primary gastric mucus-producing adenocarcinoma with signetring cells.Although transvaginal US is undoubtedly the method of choice to evaluate ovarian tumors,abdominal US and CEUS can provide key diagnostic elements,supporting clinicians in the first steps of the diagnostic work-up of abdominal and pelvic masses. | Paola Tombesi Francesca Di Vece Francesca Ermili Fabio Fabbian Sergio Sartori | 2013 | World Journal of Radiology2013，5，8： | 5 |
| 8 | Thermal ablation in colorectal liver metastases: Lack of evidence or lack of capability to prove the evidence?显示文摘Many studies suggest that combined multimodality treatments including ablative therapies may achieve better outcomes than systemic chemotherapy alone in patients with colorectal liver metastases. Nevertheless,ablative therapies are not yet considered as effective options because their efficacy has never been proved by randomized controlled trials(RCT). However, there are in literature no trials that failed in demonstrating the effectiveness of ablative treatments: what are lacking, are the trials. All the attempts to organize phase Ⅲ studies on this topic failed as a result of non accrual. Just one prospective RCT comparing radiofrequency ablation combined with systemic chemotherapy vs chemotherapy alone has been published. It was designed as a phase Ⅲ study, but it was closed early because of slow accrual, and was downscaled to phase Ⅱ study, with the consequent limits in drawing definite conclusions on the benefit of combined treatment. However, the combination treatment met the primary end point of the study and obtained a significantly higher 3-year progression-free survival than systemic chemotherapy alone. It is very unlikely that ultimate efficacy of ablation treatments will ever be tested again, and the best available evidence points toward a benefit for the combination strategy using ablative treatments and chemotherapy. | Sergio Sartori Paola Tombesi Francesca Di Vece | 2016 | World Journal of Gastroenterology2016，22，13： | 3 |
| 9 | Radiofrequency,microwave,and laser ablation of liver tumors:time to move toward a tailored ablation technique?显示文摘INTRODUCTION Primary and secondary hepatic tumors are quite common and constitute a significant source of mortality.Primary liver cancer is the fifth most common cancer worldwide and the third most common cause of cancer mortality,and secondary involvement of the liver,particularly from colorectal carcinoma,is even more common. | Paola Tombesi Francesca Di Vece Sergio Sartori | 2015 | Hepatoma Research2015，1，1： | 3 |
| 10 | Phenotyping vigour control capacity of new peach rootstocks by xylem vessel analysis显示文摘 | Tombesi S Almehdi A Dejong T M | 2011 | Scientia Horticulturae2011，127，3： | 1 |
| 11 | Macroscopic Coherence via Quantum Feedback显示文摘 | TOMBESI P VITALI D | 1995 | Phys Rev A1995，51，6： | 1 |
| 12 | Respiratory rateof olive drupes during their ripening cycle and quality of oil extraeted 显示文摘 | Ranalli A Tombesi A Ferrante ML | 1998 | Journal of Agricultural and Food Chemistry1998，77，： | 1 |
| 13 | Influence of CPPU on carbohydrate accumulation and metabolism in fruits of Actinidia deliciosa (A. Chev.)显示文摘 | E. Antognozzi A. Battistelli F. Famiani S. Moscatello F. Stanica A. Tombesi | 1996 | Scientia Horticulturae1996，，1： | 1 |
| 14 | Liver-directed therapies for liver metastases from neuroendocrine neoplasms:Can laser ablation play any role?显示文摘Aggressive cytoreduction can prolong survival in patients with unresectable liver metastases(LM)from neuroendocrine neoplasms(NEN),and minimally invasive,liver-directed therapies are gaining increasing interest.Catheter-based treatments are used in disseminated disease,whereas ablation techniques are usually indicated when the number of LM is limited.Although radiofrequency ablation(RFA)is by far the most used ablative technique,the goal of this opinion review is to explore the potential role of laser ablation(LA)in the treatment of LM from NEN.LA uses thinner needles than RFA,and this is an advantage when the tumors are in at-risk locations.Moreover,the multi-fiber technique enables the use of one to four laser fibers at once,and each fiber provides an almost spherical thermal lesion of 12-15 mm in diameter.Such a characteristic enables to tailor the size of each thermal lesion to the size of each tumor,sparing the liver parenchyma more than any other liver-directed therapy,and allowing for repeated treatments with low risk of liver failure.A recent retrospective study reporting the largest series of LM treated with LA documents both safety and effectiveness of LA,that can play a useful role in the multimodality approach to LM from NEN. | Sergio Sartori Lara Bianchi Francesca Di Vece Paola Tombesi | 2020 | World Journal of Gastroenterology2020，26，23： | 1 |
| 15 | Persistent Organic Pollutants (POPs) in the atmosphere of agricultural and urban areas in the Province of Buenos Aires in Argentina using P UF disk passive air samplers 显示文摘 | Tombesi N Pozo K Harner T | 2014 | Atmospheric Pollution Research2014，5，2： | 1 |
| 16 | Optimum leaf atea index in T-bar trained kiwifi'uit vines显示文摘 | Tombesi A Antognozzi E Palliotti A | 1994 | J Holt Sci1994，69，2： | 1 |
| 17 | Influence of assimilate availability on translocation and sink strength in kiwifruit显示文摘 | TOMBESI A ANTOGNOZZI E PALLIOTTI A | 1993 | New Zealand Journal of Crop and Horticultur al Science1993，21，2： | 1 |
| 18 | Parametric amplification and signal-to-noise ration inoptical transmission lines 显示文摘 | MECOZZI A TOMBESI P | 1995 | Opt Commum1995，75，3： | 1 |
| 19 | Differential effect of HIV-l protease inhibitors on p-glycoprotein function in multidrug-resistant variants of the human CD4+ T lymphoblastoid CEM Cell Line显示文摘 | Tombesi M Sabatini M | 2003 | Chemotherapy2003，49，： | 1 |
| 20 | Scalable quartum computation with cavity QED systems显示文摘 | GIOVANNETTI V VITALI D TOMBESI P | 2000 | Phys Rev A2000，62，03： | 1 |
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