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您的检索式：作者名="Tomoe Nishimura"
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| 1 | Comparison between the effects of ultrasound and γ-rays on the inactivation of Saccharomyces cerevisiae : Analyses of cell membrane permeability and DNA or RNA synthesis by flow cytometry显示文摘 | Ikuko Oyane Tomo Takeda Yasunori Oda Takashi Sakata Masakazu Furuta Kenji Okitsu Yasuaki Maeda Rokuro Nishimura | 2009 | Ultrasonics - Sonochemistry2009，，4： | 1 |
| 2 | A possible mechanism of intravesical BCG therapy for human bladder carcinoma: involvement of innate effector cells for the inhibition of tumor growth显示文摘 | Tomoe Higuchi Masumi Shimizu Atsuko Owaki Megumi Takahashi Eiji Shinya Taiji Nishimura Hidemi Takahashi | 2009 | Cancer Immunology Immunotherapy2009，，8： | 1 |
| 3 | Transgenic plants for allergen-specific immunotherapy显示文摘Allergen-specific immunotherapy(IT) is an effective treatment for allergic diseases. Although subcutaneous and sublingual ITs are currently used,safer,easier,and more effective IT is under development. Induction of immune tolerance by oral administration of allergen has been proven,though oral IT has not been applied clinically. It is mainly because a large amount of purified allergen is required to induce oral tolerance. To overcome this problem,plants,peculiarly rice,have been investigated as allergen vehicles for oral IT. Rice can store a considerable amount of expressed allergen in its seeds and the accumulated allergen is stable and resistant to gastrointestinal digestion. Therefore,we have developed transgenic rice seeds(Tg rice) in which major epitopes of cedar pollen or house dust mites are expressed. We are establishing Tg rice with demonstrated efficacy in murine models of allergic rhinitis and bronchial asthma by oral administration at practicaldoses. In addition,the amount,distribution,and allergenicity of the expressed allergen have been improved in our Tg rice. Rice-based oral IT is a promising new concept in IT for the treatment of allergic diseases. | Tomoe Nishimura Mayumi Saeki Osamu Kaminuma Fumio Takaiwa Takachika Hiroi | 2014 | World Journal of Immunology2014，4，3： | 0 |
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