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22篇 您的检索式：作者名="Tong WS"

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	题名	作者	年代	出处	被引量
1	MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside显示文摘MicroRNAs(miRNAs) are small, single-stranded, noncoding RNAs that can post-transcriptionally regulate the expression of various oncogenes and tumor suppressor genes. Dysregulated expression of many miRNAs have been shown to mediate the signaling pathways critical in the multistep carcinogenesis of colorectal cancer(CRC). MiR NAs are stable and protected from RNase-mediated degradation, thereby enabling its detection in biological fluids and archival tissues for biomarker studies. This review focuses on the role and application of miRNAs in the prognosis and therapy of CRC. While stage Ⅱ CRC is potentially curable by surgical resection, a significant percentage of stage Ⅱ CRC patients do develop recurrence. MiRNA biomarkers may be used to stratify such high-risk population for adjuvant chemotherapy to provide better prognoses. Growing evidence also suggests that miRNAs are involved in the metastatic process of CRC. Certain of these miRNAs may thus be used as prognostic biomarkers to identify patients more likely to have micro-metastasis, who could be monitored more closely after surgery and/or given more aggressive adjuvant chemotherapy. Intrinsic and acquired resistance to chemotherapy severely hinders successful chemotherapy in CRC treatment. Predictive miRNA biomarkers for response to chemotherapy may identify patients who will benefit the most from a particular regimen and also spare the patients from unnecessary side effects. Selection of patients to receive the new targeted therapy is becoming possible with the use of predictive miRNA biomarkers. Lastly, forced expression of tumor suppressor miRNA or silencing of oncogenic miRNA in tumors by gene therapy can also be adopted to treat CRC alone or in combination with other chemotherapeutic drugs.	Kenneth KW To Christy WS Tong Mingxia Wu William CS Cho	2018	World Journal of Gastroenterology2018，24，27：	29
2	Prognosis analysis and risk factors related to progressive intracranial haemorrhage in pa- tients with acute traumatic brain injury显示文摘	Tong WS Zheng P Zeng JS	2012	Brain Injury2012，26，9：	1
3	Early CT signs of progressive hemorrhagic injury following acute traumatic brain injury显示文摘	Tong WS Zheng P Xu JF	2011	Neuroradiology2011，53，5：	1
4	A case series of drug induced long QT syndrome and Torsa de Pointes显示文摘	Tong KL Lan YS Teo WS	2001	Singapore Med J2001，42，12：	1
5	Study on the Investigation and drug-resistance to producing extended-spectrum β-Lactamase strains in Nan Jing area 显示文摘	Zhao WS Xu NS Ge YX Tong MQ	2000	Linchuang Jianyan Zazhi (Chin J Clin Lab Sci)2000，18，4：	1
6	A case series of drug-induced long QT syndrome and Torsades de Pointes 显示文摘	Tong KL Lan YS Teo WS	2002	Singapore Med J2002，42，12：	1
7	Early CT signs of progressive hemorrhagic injury following acute traumatic brain injury显示文摘	Tong WS Zheng P Xu JF	2011	Neu- roradiology2011，53，5：	1
8	Early CT signs of progressive hemorrhagic injury following acute traumatic brain injury显示文摘	Tong WS Zhang P Xu JF	2011	Neu- roradiology2011，53，5：	1
9	Study of 202natural,synthetic,and environmental chemicals for binding to the androgen receptor显示文摘	Fang H Tong W Branham WS	2003	Chem Res Toxicol2003，16，：	1
10	Prognosis analysis and risk factors related to progressive intracranial haemorrhage in pao tients with acute traumatic brain injury显示文摘	Tong WS Zheng P Zeng JS	2012	Brain Inj2012，26，9：	1
11	Early CT signs of progressive hemorrhagic injury following acute traumatic brain injury 显示文摘	Tong WS Zheng P Xu JF	2010	Neuroradiology2010，10，4：	1
12	Prognosis analysis and risk factors related to progressive intracranial haemorrhage in patients with acute traumatic brain injury 显示文摘	Tong WS Zheng P Zeng JS	2012	Brain Inj2012，26，9：	1
13	Early CT signs of progressive hem-orrhagic injury following acute traumatic brain injury 显示文摘	Tong WS Zheng P Xu JF	2011	Neurora- diology2011，53，5：	1
14	Prognosisanalysis and risk factors related to progres-sive intracranial haemorrhage in patientswith acute traumatic brain injury 显示文摘	Tong WS Zheng P Zeng JS	2012	BrainInj2012，26，9：	1
15	Early CT signs of progressivehemorrhagic injury following acute traumatic brain injury 显示文摘	Tong WS Zheng P Xu JF	2010	Neuroradiology2010，53，5：	1
16	Decrease in pituitary apparent diffusion coeficient in normal appearing brain correlates with hypopituitarism following traumatic brain injury显示文摘	ZHENG P I-IE B TONG WS	2014	J Endocrino Invest2014，37，：	1
17	Early CT signs of progressive hemorrhage injury following acute traumatic brain injury 显示文摘	Tong WS Zheng P Xu JF		Neuroradiology0，53，：	1
18	Prognosis analysis and risk factors related to progressive intracranial haemorrhage in patients with acute traumatic brain injury显示文摘	Tong WS Zheng P Zeng JS	2012	Brain Inj2012，26，9：	1
19	Prognosis analysis and risk factors related to progressive intraeranial haemorrhage in patients with acute traumatic brain injury显示文摘	Tong WS Zheng P Zeng JS	2012	Brain Int2012，26，9：	1
20	Early CT signs of progres-sive hemorrhagic injury following acute traumatic brain in-jury显示文摘	Tong WS Zheng P Xu JF	2011	Neuroradiology2011，53，5：	1

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