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您的检索式：作者名="Tongqing An"
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| 1 | Junction and Evolution of the Qinling,Qilian and Kunlun Orogenic Belts显示文摘As the main part of the 'central mountain system' in the continent of China, the Qinling, Qilian and Kunlun orogenic belts have been comprehensively and deeply studied since the 1970s and rich fruits have been reaped. However, these achievements were mostly confined to an individual orogenic belt and the study of the mutual relationship among the three orogenic belts was obliged to depend on comparative studies. Different views were produced therefrom. The material composition and structural features of the junction region show that there are several epicontinental and intracontinental transform faults developed in different periods. Restricted by these transform faults, the large-scale lateral movements and, as a consequence, complicated magrnatism and tectonic deformation took place in the orogenic belts. According to these features, the authors put forward a three-stage junction and evolution model and point out that there is not a single junction zone traversing from west to east but that the | SUN Yangui CHEN Zhengxing LIU Yong’an WANG Tongqing ZHANG Zhiyong | 2000 | Acta Geologica Sinica(English Edition)2000，74，2： | 6 |
| 2 | Andrographolide and Its Derivative Potassium Dehydrographolide Succinate Suppress PRRSV Replication in Primary and Established Cells via Differential Mechanisms of Action显示文摘Porcine reproductive and respiratory syndrome virus(PRRSV) continues to cause significant economic loss worldwide and remains a serious threat to the pork industry. Currently, vaccination strategies provide limited protection against PRRSV infection, and consequently, new antiviral strategies are urgently required. Andrographolide(Andro) and its derivative potassium dehydrographolide succinate(PDS) have been used clinically in China and other Asian countries as therapies for inflammation-related diseases, including bacterial and viral infections, for decades. Here, we demonstrate that Andro and PDS exhibit robust activity against PRRSV replication in Marc-145 cells and primary porcine alveolar macrophages(PAMs). The two compounds exhibited broad-spectrum inhibitory activities in vitro against clinically circulating type 2 PRRSV GD-HD, XH-GD, and NADC30-like HNhx strains in China. The EC_(50)values of Andro against three tested PRRSV strain infections in Marc-145 cells ranged from 11.7 to 15.3 lmol/L, with selectivity indexes ranging from 8.3 to10.8, while the EC_(50)values of PDS ranged from 57.1 to 85.4 lmol/L, with selectivity indexes ranging from 344 to 515.Mechanistically, the anti-PRRSV activity of the two compounds is closely associated with their potent suppression on NFj B activation and enhanced oxidative stress induced by PRRSV infection. Further mechanistic investigations revealed that PDS, but not Andro, is able to directly interact with PRRSV particles. Taken together, our findings suggest that Andro and PDS are promising PRRSV inhibitors in vitro and deserves further in vivo studies in swine. | Lizhan Su Yarou Gao Mingxin Zhang Zexin Liu Qisheng Lin Lang Gong Jianying Guo Lixia Chen Tongqing An Jianxin Chen | 2021 | Virologica Sinica2021，36，6： | 4 |
| 3 | Identification of anovel B cell epitope on nucleocapsid protein of porcine reproduc-tive and respiratory and respiratory syndrome virus by phage dis-play显示文摘 | An Tongqing Zhou Yanjun Qiu Huaji | 2005 | Virus Genes2005，31，1： | 1 |
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