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| 1 | Biomechanical change of lumbar unilateral graded facetectomy and strategies of its microsurgical reconstruction:report of 23 cases显示文摘评估腰部的稳定性和单方的 facetectomy 的主要临床的结果的目的, transforaminal 腰部的 interbody 熔化(TLIF ) 和由 X 试管的单方的小花梗螺丝钉固定系统。方法五人的腰部的 cadaveric 功能的脊骨单位(FSU ) 被 0 获得并且分级 facetectomy, 1/4, 1/2, 3/4 和 4/4 在他们的左关节的过程上分别地被执行。这 5 个模型的稳定性在屈曲,延期,侧面的弯曲和轴的旋转被评估。在 biomechanical 研究的一个连续剧以后,到在我们的部门的 2006 年 3 月的从 2004 年 6 月的 23 个病人经历了单方的 facetectomy, transforaminal 腰部的 interbody 熔化(以后的腰部的 interbody 熔化) 和由 X 试管的单方的小花梗螺丝钉乐器学系统。在一般麻醉以后,与荧光检查并且用 X 试管系统的指南,单方的内视镜的 facetectomy 的过程,针的神经根解压缩, autologus 多孔的骨头移植,一个笼子倾斜的插入和单方的小花梗螺丝钉乐器学被执行。在那里的结果不是在屈曲,延期,在单方的分级的 facetectomy 以后的侧面的弯曲和腰部的运动范围的轴的旋转的重要差别。当时,左 / 权利的轴的方向的稳定性极大地被影响分级的 facetectomy 的范围超过 1/2。根据 Nakai 标准,为 23 个病人,临床的结果在 15 是优秀的(65.2%) ,在 6 好(26.1%) 并且在 2 的交易会(8.7%) 。熔化率在优秀、好的盒子中是 95.6% 。尽管骨头接枝的部分吸收在可能显示失败的熔化的 1 种情况中被观察,没有松开,仪器和没有临床的症状的代替发生了。当分级的 facetectomy 的范围超过 1/2 时,腰部的稳定性将显著地被影响的结论。单方的 facetectomy 的过程, transforaminal 腰部的 interbody 熔化和单方的小花梗螺丝钉固定是为 microsurgical 重建的可选的策略,不过,过程的指示应该小心地被限制。 | Zhou Yue Luo Gang Chu Tongwei Wang Jian Li Changqing Zheng Wenjie Zhang Zhengfeng Hao Yong Zhang Chao | 2008 | Journal of Medical Colleges of PLA(China)2008，23，2： | 2 |
| 2 | Spindle and Kinetochore-associated Family Genes are Prognostic and Predictive Biomarkers in Hepatocellular Carcinoma显示文摘Background and Aims:Hepatocellular carcinoma(HCC)is one of the most frequent malignant tumors.Spindle and kinetochore-associated(SKA)family genes are essential for the maintenance of the metaphase plate and spindle checkpoint silencing during mitosis.Recent studies have indicated that dysregulation of SKA family genes induces tumorigenesis,tumor progression,and chemoresistance via modulation of cell cycle and DNA replication.However,the differential transcription of SKAs in the context of HCC and its prognostic significance has not been demonstrated.Methods:Bioinformatics analyses were performed using TCGA,ONCOMINE,HCCDB,Kaplan-Meier plotter,STRING,GEPIA databases.qRT-PCR,western blot,and functional as-says were utilized for in vitro experiments.Results:We found remarkable upregulation of transcripts of SKA family genes in HCC samples compared with normal liver samples on bioinformatics analyses and in vitro validation.Inter-action analysis and enrichment analysis showed that SKA family members were mainly related to microtubule motor activity,mitosis,and cell cycle.Immuno-infiltration analysis showed a correlation of all SKA family genes with various immune cell subsets,especially T helper 2(Th2)cells.Tran-scriptional levels of SKA family members were positively as-sociated with histologic grade,T stage,andα-fetoprotein in HCC patients.Receiver operating characteristic curve analy-sis demonstrated a strong predictive ability of SKA1/2/3 for HCC.Increased expression of these SKAs was associated with unfavorable overall survival,progression-free survival,and disease-specific survival.On Cox proportional hazards regression analyses,SKA1 upregulation and pathological staging were independent predictors of overall survival and disease-specific survival of HCC patients.Finally,clinical tissue microarray validation and in vitro functional assays revealed SKA1 acts an important regulatory role in tumor malignant behavior.Conclusions:SKA family members may potentially serve as diagnostic and prognostic markers in the context of HCC.The correlation between SKAs and immune cell infiltration provides a promising research direc-tion for SKA-targeted immunotherapeutics for HCC. | Chenhui Cai Ying Zhang Xu Hu Sizhen Yang Jiawen Ye Zihan Wei Tongwei Chu | 2022 | Journal of Clinical and Translational Hepatology2022，10，4： | 0 |
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